Role of Microgliosis and NLRP3 Inflammasome in Parkinson’s Disease Pathogenesis and Therapy

2021 ◽  
Author(s):  
Fillipe M. de Araújo ◽  
Lorena Cuenca-Bermejo ◽  
Emiliano Fernández-Villalba ◽  
Silvia L. Costa ◽  
Victor Diogenes A. Silva ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nlrp3 Inflammasome ◽  
Disease Pathogenesis

The key role of T cells in Parkinson's disease pathogenesis and therapy

2019 ◽  
Vol 60 ◽  
pp. 25-31 ◽  
Author(s):  
Jill K. Baird ◽  
Dennis Bourdette ◽  
Charles K. Meshul ◽  
Joseph F. Quinn
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
T Cells ◽  
Disease Pathogenesis

scholarly journals Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease

Glia ◽  
2015 ◽  
Vol 64 (3) ◽  
pp. 386-395 ◽  
Author(s):  
Heather L. Martin ◽  
Matteo Santoro ◽  
Sarah Mustafa ◽  
Gernot Riedel ◽  
John V. Forrester ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Immune Response ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Adaptive Immune Response ◽  
Disease Pathogenesis ◽  
Adaptive Immune

scholarly journals Regional transcriptional architecture of Parkinson’s disease pathogenesis and network spread

Brain ◽  
2019 ◽  
Vol 142 (10) ◽  
pp. 3072-3085 ◽  
Author(s):  
Benjamin Freeze ◽  
Sneha Pandya ◽  
Yashar Zeighami ◽  
Ashish Raj
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Regions ◽  
Disease Spread ◽  
Disease Pathogenesis ◽  
Diffusion Modelling ◽  
Network Diffusion

The role of genetics in controlling the spread of pathology between brain regions in Parkinson’s disease is largely unclear. Freeze et al. report that regional microglial abundance and transcription of immune-related and lysosomal genes predict pathology seed regions and disease spread inferred from network diffusion modelling of MRI-derived atrophy maps.

scholarly journals The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

2017 ◽  
Vol 40 (6) ◽  
pp. 358-370 ◽  
Author(s):  
Heather D.E. Booth ◽  
Warren D. Hirst ◽  
Richard Wade-Martins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Pathogenesis
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