A parallel cellular automata algorithm for the deterministic simulation of 3-D multicellular tissue growth

2015 ◽  
Vol 18 (4) ◽  
pp. 1561-1579 ◽  
Author(s):  
Belgacem Ben Youssef
Author(s):  
Belgacem Ben Youssef ◽  
Lenny Tang

In this paper, the authors describe a computational model for the growth of multicellular tissues using a discrete approach based on cellular automata to simulate the tissue growth rates and population dynamics of multiple populations of proliferating and migrating cells. Each population of cells has its own division, motion, collision, and aggregation characteristics. These random dynamic processes can be modeled by appropriately choosing the governing rules of the state transitions of each computational site. This extended model contains a number of system parameters that allow their effects on the volume coverage, the overall tissue growth rate, and some other aspects of cell behavior like the average speed of locomotion to be explored. These discrete systems provide an alternative approach to continuous models for the purpose of describing the temporal dynamics of complex systems.


2005 ◽  
Author(s):  
Yujie Wu ◽  
Qiang Yu ◽  
Sven K. Esche

This paper reports on one part of a research project supported by NSF, which aims at developing a multi-scale methodology for systematic microstructure prediction in thermo-mechanical processing of metals. Based on combining mesoscopic microstructure models with macroscopic process formulations, the methodology is expected to provide universally applicable and accurate microstructure prediction capabilities. Cellular Automata (CA) models have been widely used in scientific studies of various microstructural phenomena. This paper discusses the modeling of the static recrystallization phenomenon by employing a regular CA algorithm. The recrystallization processes of single-phase systems under different nucleation conditions are simulated followed by the recrystallization kinetics analysis for 200 × 200 two-dimensional lattice. The performed simulations of static recrystallization confirm that the recrystallized volume fractions are time dependent. Furthermore, the simulated microstructures validate the following Johnson-Mehl-Avrami-Kolmogorov (JMAK) model according to which the recrystallized volume fraction is a sigmoidal function of time, and their evolution matches the JMAK equation with the expected exponents.


2010 ◽  
Vol 1 (3) ◽  
pp. 1-18 ◽  
Author(s):  
Belgacem Ben Youssef ◽  
Lenny Tang

In this paper, the authors describe a computational model for the growth of multicellular tissues using a discrete approach based on cellular automata to simulate the tissue growth rates and population dynamics of multiple populations of proliferating and migrating cells. Each population of cells has its own division, motion, collision, and aggregation characteristics. These random dynamic processes can be modeled by appropriately choosing the governing rules of the state transitions of each computational site. This extended model contains a number of system parameters that allow their effects on the volume coverage, the overall tissue growth rate, and some other aspects of cell behavior like the average speed of locomotion to be explored. These discrete systems provide an alternative approach to continuous models for the purpose of describing the temporal dynamics of complex systems.


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