hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells

2022 ◽  
Author(s):  
Ganlin Xia ◽  
Anxin Wang ◽  
Liangxue Li
2021 ◽  
Vol 20 (1) ◽  
pp. 153-158
Author(s):  
Abulajiang Abudoukelimu ◽  
Xinhui Yang ◽  
Lei Ge ◽  
Xiangyue Zeng ◽  
Yin Shu ◽  
...  

Gastric cancer is a highly malignant tumor of the digestive tract with high incidence rate and mortality. In the present study, we have shown decreased cell proliferation, increased apoptosis, and expression of proinflammatory cytokines (Interleukin-6, Interleukin-1β, and Tumor necrosis factor-α) in gastric cancer cells MGC-803 by amygdalin. Also, amygdalin treatment significantly reduced expression of the mRNA and protein for B-cell lymphoma 2 protein, CyclinD1, toll-like receptor 4, and REL-associated protein involved in NF-κB heterodimer formation in MGC-803 cells. In summary, amygdalin inhibits the proliferation of gastric cancer cells MGC-803 and promotes cell apoptosis by regulating the toll-like receptor 4/ nuclear factor-kappa B signaling pathway.


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2012 ◽  
Vol 59 (04) ◽  
pp. 416-423 ◽  
Author(s):  
H. WANG ◽  
Z. LIU ◽  
J. LI ◽  
X. ZHAO ◽  
Z. WANG ◽  
...  

2016 ◽  
Vol 24 (21) ◽  
pp. 3262
Author(s):  
Hai-Yun Tao ◽  
Zhong-Yu Qu ◽  
Guang-Min Wei ◽  
Jing Sheng ◽  
Wen-Lian Wang ◽  
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2020 ◽  
Vol Volume 13 ◽  
pp. 2333-2345
Author(s):  
Xiaomeng Jiang ◽  
Menglin Jiang ◽  
Shuhua Guo ◽  
Pengpeng Cai ◽  
Wei Wang ◽  
...  

2016 ◽  
Vol 13 (6) ◽  
pp. 4981-4986 ◽  
Author(s):  
WEIYUE ZHANG ◽  
QIAOYAN ZHANG ◽  
YIPING JIANG ◽  
FENG LI ◽  
HAILIANG XIN

2013 ◽  
Vol 5 (3) ◽  
pp. 801-804 ◽  
Author(s):  
YI ZHANG ◽  
XIAO-MAN XU ◽  
MENG ZHANG ◽  
DAN QU ◽  
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...  

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