Phase I study of CKD-581, a pan-histone deacetylase inhibitor, in patients with lymphoma or multiple myeloma refractory to standard therapy

Investigational New Drugs ◽

10.1007/s10637-018-0582-0 ◽

2018 ◽

Vol 36 (5) ◽

pp. 877-885 ◽

Author(s):

Hyungwoo Cho ◽

Dok Hyun Yoon ◽

Kyu-pyo Kim ◽

Kyun-Seop Bae ◽

Won Seog Kim ◽

...

Keyword(s):

Multiple Myeloma ◽

Phase I ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Standard Therapy ◽

Phase I Study ◽

Deacetylase Inhibitor

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Faculty of 1000 evaluation for A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718050520.793482822 ◽

2013 ◽

Author(s):

Burton Eisenberg

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Pediatric Patients ◽

Deacetylase Inhibitor

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A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-13-0312 ◽

2013 ◽

Vol 19 (15) ◽

pp. 4262-4272 ◽

Author(s):

Balaji Venugopal ◽

Richard Baird ◽

Rebecca S. Kristeleit ◽

Ruth Plummer ◽

Richard Cowan ◽

...

Keyword(s):

Antitumor Activity ◽

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Advanced Solid Tumors ◽

Deacetylase Inhibitor

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Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-012-1847-5 ◽

2012 ◽

Vol 69 (6) ◽

pp. 1413-1422 ◽

Author(s):

Mei Dong ◽

Zhi-Qiang Ning ◽

Pu-Yuan Xing ◽

Jia-Lian Xu ◽

Hai-Xiang Cao ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Advanced Solid Tumors ◽

Deacetylase Inhibitor

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Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours

British Journal of Cancer ◽

10.1038/bjc.2011.527 ◽

2011 ◽

Vol 106 (1) ◽

pp. 77-84 ◽

Author(s):

R Pili ◽

B Salumbides ◽

M Zhao ◽

S Altiok ◽

D Qian ◽

...

Keyword(s):

Retinoic Acid ◽

Phase I ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Solid Tumours ◽

Deacetylase Inhibitor

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Abstract 1172: Phase I study of histone deacetylase inhibitor belinostat in combination with warfarin in patients with solid tumors or hematological malignancies.

10.1158/1538-7445.am2013-1172 ◽

2013 ◽

Author(s):

Neeraj Agarwal ◽

Mark L. Wade ◽

Julia Batten ◽

Cynthia Davidson ◽

Show-Li Sun ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Hematological Malignancies ◽

Deacetylase Inhibitor

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Faculty of 1000 evaluation for A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718050520.793482405 ◽

2013 ◽

Author(s):

Daniel Indelicato

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Pediatric Patients ◽

Deacetylase Inhibitor

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Phase I study of the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the histone deacetylase inhibitor (HDACi) PCI-24781

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.14514 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 14514-14514 ◽

Author(s):

S. D. Undevia ◽

L. Janisch ◽

R. L. Schilsky ◽

D. Loury ◽

S. Balasubramanian ◽

...

Keyword(s):

Phase I ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Deacetylase Inhibitor

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A first-in-human phase I study of JNJ-26481585, a novel oral histone deacetylase inhibitor (HDACi), in patients with advanced cancer with evidence of target modulation and antitumor activity.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.3024 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 3024-3024 ◽

Author(s):

R. D. Baird ◽

B. Venugopal ◽

R. S. Kristeleit ◽

J. Charlton ◽

M. Blanco-Codesido ◽

...

Keyword(s):

Antitumor Activity ◽

Phase I ◽

Histone Deacetylase ◽

Advanced Cancer ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Deacetylase Inhibitor

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First-in-human, Pharmacokinetic and Pharmacodynamic Phase I Study of Resminostat, an Oral Histone Deacetylase Inhibitor, in Patients with Advanced Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-13-0735 ◽

2013 ◽

Vol 19 (19) ◽

pp. 5494-5504 ◽

Author(s):

André T. Brunetto ◽

Joo Ern Ang ◽

Rohit Lal ◽

David Olmos ◽

L. Rhoda Molife ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Advanced Solid Tumors ◽

Deacetylase Inhibitor ◽

Human Pharmacokinetic

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A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium

Pediatric Blood & Cancer ◽

10.1002/pbc.24694 ◽

2013 ◽

Vol 60 (11) ◽

pp. 1868-1874 ◽

Author(s):

Alexandra P. Zorzi ◽

Mark Bernstein ◽

Yvan Samson ◽

Donna A. Wall ◽

Sunil Desai ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Phase I Study ◽

Pediatric Patients ◽

Deacetylase Inhibitor

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