scholarly journals Season of birth and the risk of dementia in the population‐based Rotterdam Study

2021 ◽  
Author(s):  
Sanne S. Mooldijk ◽  
Silvan Licher ◽  
Elisabeth J. Vinke ◽  
Meike W. Vernooij ◽  
Mohammad Kamran Ikram ◽  
...  
Keyword(s):  
Cox Regression ◽  
Underlying Mechanism ◽  
Population Based ◽  
Season Of Birth ◽  
Rotterdam Study ◽  
Cold Winter ◽  
Brain Changes ◽  
Imaging Markers ◽  
External Exposures ◽  
Structural Brain

AbstractEarly-life environmental factors have been suggested in the pathophysiology of dementia. Season of birth has previously been used as a proxy for these external exposures. We investigated the link between season of birth and the risk of dementia and further explored underlying pathways by studying structural brain changes on MRI. From the Dutch, population-based Rotterdam Study, 12,964 participants born between 1887 and 1960 were followed between 1990 and 2018 for dementia. Cox regression was conducted to assess the association between season of birth and dementia. In addition, we distinguished between mild and cold winters. The association of season of birth with structural brain markers on MRI was examined in 5237 participants. The risk of dementia in participants born in winter and fall was higher than of those born in summer (hazard ratio (HR) 1.15 [95% confidence interval (CI) 1.01–1.31] for winter and HR 1.17 [95% CI 1.01–1.33] for fall), especially for Alzheimer’s disease (HR 1.23 [1.06–1.43] for winter and HR 1.15 [95% CI 0.99–1.35] for fall). The risk was particularly increased for participants born in a cold winter. Except for slightly lower hippocampus in fall born participants (β − 0.03; 95% CI − 0.06 to 0.00), we did not find associations with brain imaging markers. In conclusion, winter and fall births were associated with a higher incidence of dementia, especially of AD. We did not find evidence for structural brain changes as an underlying mechanism.

scholarly journals Apnea-hypopnea index, nocturnal arousals, oxygen desaturation and structural brain changes: A population-based study

2016 ◽  
Vol 1 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Lisette A. Zuurbier ◽  
Meike W. Vernooij ◽  
Annemarie I. Luik ◽  
Desana Kocevska ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Population Based ◽  
Oxygen Desaturation ◽  
Apnea Hypopnea Index ◽  
Population Based Study ◽  
Brain Changes ◽  
Structural Brain

P1-020: Structural brain changes mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P344-P344
Author(s):  
Rui Wang ◽  
Laura Fratiglioni ◽  
Grégoria Kalpouzos ◽  
Martin Lövdén ◽  
Erika Jonsson Laukka ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cognitive Decline ◽  
Old Age ◽  
Population Based ◽  
Population Based Study ◽  
Brain Changes ◽  
Structural Brain

scholarly journals Arterial calcification at multiple sites: sex-specific cardiovascular risk profiles and mortality risk—the Rotterdam Study

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Janine E. van der Toorn ◽  
Oscar L. Rueda-Ochoa ◽  
Niels van der Schaft ◽  
Meike W. Vernooij ◽  
M. Arfan Ikram ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Mortality Risk ◽  
Cox Regression ◽  
Population Based ◽  
Arterial Calcification ◽  
Future Research ◽  
Rotterdam Study ◽  
Risk Profiles ◽  
Severe Calcification

Abstract Background Evidence has pointed towards differences in the burden of arteriosclerosis according to its location and sex. Yet there is a scarcity of population-based data on aggregated sex-specific cardiovascular risk profiles, instead of single risk factors, and mortality risk according to the location of arteriosclerosis. We assessed sex-specific cardiovascular risk profiles and mortality risk associated with arteriosclerosis. Methods From the population-based Rotterdam Study, 2357 participants (mean age 69 years, 53% women) underwent non-contrast computed tomography to quantify calcification, as a proxy for arteriosclerosis, in the coronary arteries (CAC), aortic arch (AAC), extracranial (ECAC) and intracranial carotid arteries (ICAC), vertebrobasilar arteries (VBAC), and aortic valve (AVC). Principal component analysis (PCA) of eight distinct cardiovascular risk factors was performed, separately for women and men, to derive risk profiles based on the shared variance between factors. We used sex-stratified multivariable logistic regression to examine the associations between PCA-derived risk profiles and severe calcification at different locations. We investigated the associations of severe calcification with mortality risk using sex-stratified multivariable Cox regression. Results PCA identified three cardiovascular risk profiles in both sexes: (1) anthropometry, glucose, and HDL cholesterol; (2) blood pressure; and (3) smoking and total cholesterol. In women, the strongest associations were found for profile 2 with severe ECAC and ICAC (adjusted OR [95% CI] 1.32 [1.14–1.53]) and for profile 3 with severe at all locations, except AVC. In men, the strongest associations were found for profile 2 with VBAC (1.31 [1.12–1.52]) and profile 3 with severe AAC (1.28 [1.09–1.51]). ECAC and AVC in women and CAC in men showed the strongest, independent associations with cardiovascular mortality (HR [95% CI] 2.11 [1.22–3.66], 2.05 [1.21–3.49], 2.24 [1.21–3.78], respectively). Conclusions Our findings further underline the existence of sex- and location-specific differences in the etiology and consequences of arteriosclerosis. Future research should unravel which distinct pathological processes underlie differences in risk profiles for arteriosclerosis.

scholarly journals Social Health Is Associated With Structural Brain Changes in Older Adults: The Rotterdam Study

2021 ◽  
Author(s):  
Isabelle F. van der Velpen ◽  
René J.F. Melis ◽  
Marieke Perry ◽  
Myrra J.F. Vernooij-Dassen ◽  
M. Arfan Ikram ◽  
...  
Keyword(s):  
Older Adults ◽  
Social Health ◽  
Rotterdam Study ◽  
Brain Changes ◽  
Structural Brain

Nocturnal intermittent hypoxia and structural brain changes: a population-based study

2019 ◽  
Vol 64 ◽  
pp. S275-S276
Author(s):  
S. Kim ◽  
H.R. Nam ◽  
R.E. Kim ◽  
H.M. Ahn ◽  
S.K. Lee ◽  
...  
Keyword(s):  
Intermittent Hypoxia ◽  
Population Based ◽  
Population Based Study ◽  
Brain Changes ◽  
Structural Brain

Structural brain changes in tinnitus: grey matter decrease in auditory and non-auditory brain areas

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
M Landgrebe ◽  
K Rosengarth ◽  
A Koch ◽  
T Kleinjung ◽  
A May ◽  
...  
Keyword(s):  
Grey Matter ◽  
Brain Areas ◽  
Brain Changes ◽  
Structural Brain

Does Hospitalization Predict the Disease Course in Ulcerative Colitis? Prevalence and Predictors of Hospitalization and Re- Hospitalization in Ulcerative Colitis in a Population-based Inception Cohort (2000-2012)

2015 ◽  
Vol 24 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Petra A. Golovics ◽  
Laszlo Lakatos ◽  
Michael D. Mandel ◽  
Barbara D. Lovasz ◽  
Zsuzsanna Vegh ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cox Regression ◽  
Diagnostic Procedures ◽  
Population Based ◽  
Disease Course ◽  
Inception Cohort ◽  
Disease Extent ◽  
Cox Regression Analysis ◽  
Hospitalization Rates

Background & Aims: Limited data are available on the hospitalization rates in population-based studies. Since this is a very important outcome measure, the aim of this study was to analyze prospectively if early hospitalization is associated with the later disease course as well as to determine the prevalence and predictors of hospitalization and re-hospitalization in the population-based ulcerative colitis (UC) inception cohort in the Veszprem province database between 2000 and 2012. Methods: Data of 347 incident UC patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (M/F: 200/147, median age at diagnosis: 36, IQR: 26-50 years, follow-up duration: 7, IQR 4-10 years). Both in- and outpatient records were collected and comprehensively reviewed. Results: Probabilities of first UC-related hospitalization were 28.6%, 53.7% and 66.2% and of first re-hospitalization were 23.7%, 55.8% and 74.6% after 1-, 5- and 10- years of follow-up, respectively. Main UC-related causes for first hospitalization were diagnostic procedures (26.7%), disease activity (22.4%) or UC-related surgery (4.8%), but a significant percentage was unrelated to IBD (44.8%). In Kaplan-Meier and Cox-regression analysis disease extent at diagnosis (HR extensive: 1.79, p=0.02) or at last follow-up (HR: 1.56, p=0.001), need for steroids (HR: 1.98, p<0.001), azathioprine (HR: 1.55, p=0.038) and anti-TNF (HR: 2.28, p<0.001) were associated with the risk of UC-related hospitalization. Early hospitalization was not associated with a specific disease phenotype or outcome; however, 46.2% of all colectomies were performed in the year of diagnosis. Conclusion: Hospitalization and re-hospitalization rates were relatively high in this population-based UC cohort. Early hospitalization was not predictive for the later disease course.

Fracture Risk in Patients with Myasthenia Gravis: A Population-Based Cohort Study

2021 ◽  
pp. 1-8
Author(s):  
Charles Kassardjian ◽  
Jessica Widdifield ◽  
J. Michael Paterson ◽  
Alexander Kopp ◽  
Chenthila Nagamuthu ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Lower Risk ◽  
Cox Regression ◽  
Large Population ◽  
Population Based ◽  
Osteoporosis Prevention ◽  
Inception Cohort ◽  
Hazard Ratios ◽  
Multiple Covariates ◽  
Region Of Residence

Background: Prednisone is a common treatment for myasthenia gravis (MG), and osteoporosis is a known potential risk of chronic prednisone therapy. Objective: Our aim was to evaluate the risk of serious fractures in a population-based cohort of MG patients. Methods: An inception cohort of patients with MG was identified from administrative health data in Ontario, Canada between April 1, 2002 and December 31, 2015. For each MG patient, we matched 4 general population comparators based on age, sex, and region of residence. Fractures were identified through emergency department and hospitalization data. Crude overall rates and sex-specific rates of fractures were calculated for the MG and comparator groups, as well as rates of specific fractures. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression. Results: Among 3,823 incident MG patients (followed for a mean of 5 years), 188 (4.9%) experienced a fracture compared with 741 (4.8%) fractures amongst 15,292 matched comparators. Crude fracture rates were not different between the MG cohort and matched comparators (8.71 vs. 7.98 per 1000 patient years), overall and in men and women separately. After controlling for multiple covariates, MG patients had a significantly lower risk of fracture than comparators (HR 0.74, 95% CI 0.63–0.88). Conclusions: In this large, population-based cohort of incident MG patients, MG patients were at lower risk of a major fracture than comparators. The reasons for this finding are unclear but may highlight the importance osteoporosis prevention.

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