Heightened perception of breast cancer risk in young women at risk of familial breast cancer

2017 ◽  
Vol 17 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Rachael Glassey ◽  
◽  
Moira O’Connor ◽  
Angela Ives ◽  
Christobel Saunders ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Young Women ◽  
Familial Breast Cancer

Feeling at risk: How women interpret their familial breast cancer risk

2004 ◽  
Vol 131A (1) ◽  
pp. 42-49 ◽  
Author(s):  
Sandra van Dijk ◽  
Wilma Otten ◽  
Christi J. van Asperen ◽  
Danielle R.M. Timmermans ◽  
Aad Tibben ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Familial Breast Cancer ◽  
Familial Breast Cancer Risk

Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk

2006 ◽  
Vol 118 (10) ◽  
pp. 2505-2508 ◽  
Author(s):  
Bernd Frank ◽  
Kari Hemminki ◽  
Alfons Meindl ◽  
Barbara Wappenschmidt ◽  
Rüdiger Klaes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Familial Breast Cancer ◽  
Familial Breast Cancer Risk

scholarly journals Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage

2020 ◽  
Vol 17 (2) ◽  
pp. 493 ◽  
Author(s):  
Rama Natarajan ◽  
Dana Aljaber ◽  
Dawn Au ◽  
Christine Thai ◽  
Angelica Sanchez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Young Women ◽  
Food Additives ◽  
Environmental Exposures ◽  
Cost Effective ◽  
Environmental Damage ◽  
Environmental Carcinogens ◽  
Molecular Damage

During puberty, a woman’s breasts are vulnerable to environmental damage (“window of vulnerability”). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized to promote molecular damage that increases breast cancer risk. However, prospective human studies are difficult to perform and effective interventions to prevent these early exposures are lacking. It is difficult to prevent environmental exposures during puberty. Specifically, young women are repeatedly exposed to media messaging that promotes unhealthy foods. Young women living in disadvantaged neighborhoods experience additional challenges including a lack of access to healthy food and exposure to contaminated air, water, and soil. The purpose of this review is to gather information on potential exposures during puberty. In future directions, this information will be used to help elementary/middle-school girls to identify and quantitate environmental exposures and develop cost-effective strategies to reduce exposures.

scholarly journals Pubertal timing and breast density in young women: a prospective cohort study

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Lauren C. Houghton ◽  
Seungyoun Jung ◽  
Rebecca Troisi ◽  
Erin S. LeBlanc ◽  
Linda G. Snetselaar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Density ◽  
Young Women ◽  
Geometric Mean ◽  
Age At Onset ◽  
Breast Development ◽  
Increased Risk ◽  
Pubertal Tempo

Abstract Background Earlier age at onset of pubertal events and longer intervals between them (tempo) have been associated with increased breast cancer risk. It is unknown whether the timing and tempo of puberty are associated with adult breast density, which could mediate the increased risk. Methods From 1988 to 1997, girls participating in the Dietary Intervention Study in Children (DISC) were clinically assessed annually between ages 8 and 17 years for Tanner stages of breast development (thelarche) and pubic hair (pubarche), and onset of menses (menarche) was self-reported. In 2006–2008, 182 participants then aged 25–29 years had their percent dense breast volume (%DBV) measured by magnetic resonance imaging. Multivariable, linear mixed-effects regression models adjusted for reproductive factors, demographics, and body size were used to evaluate associations of age and tempo of puberty events with %DBV. Results The mean (standard deviation) and range of %DBV were 27.6 (20.5) and 0.2–86.1. Age at thelarche was negatively associated with %DBV (p trend = 0.04), while pubertal tempo between thelarche and menarche was positively associated with %DBV (p trend = 0.007). %DBV was 40% higher in women whose thelarche-to-menarche tempo was 2.9 years or longer (geometric mean (95%CI) = 21.8% (18.2–26.2%)) compared to women whose thelarche-to-menarche tempo was less than 1.6 years (geometric mean (95%CI) = 15.6% (13.9–17.5%)). Conclusions Our results suggest that a slower pubertal tempo, i.e., greater number of months between thelarche and menarche, is associated with higher percent breast density in young women. Future research should examine whether breast density mediates the association between slower tempo and increased breast cancer risk.

Placental Weight and Breast Cancer Risk in Young Women: A Registry-Based Cohort Study from Norway

2012 ◽  
Vol 21 (7) ◽  
pp. 1060-1065 ◽  
Author(s):  
Signe Opdahl ◽  
Mirjam D.K. Alsaker ◽  
Pål R. Romundstad ◽  
Anne Eskild ◽  
Lars J. Vatten
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Young Women ◽  
Placental Weight

Familial Breast Cancer: Risk to the Contralateral Breast 2

1978 ◽  
Vol 60 (5) ◽  
pp. 955-960 ◽  
Author(s):  
Randall E. Harris ◽  
Henry T. Lynch ◽  
Hoda A. Guirgis
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Familial Breast Cancer ◽  
Contralateral Breast ◽  
Familial Breast Cancer Risk
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