The chapter deals with the global issue of advancing women's role in higher education and research (HE&R) as a mechanism for reaching the Sustainable Development Goal 5 – gender equality. Gender analysis method is employed to identify historical and current differences between women and men relative to their participation in HE&R and access to decision-making and resources therein. The focus is on the global challenge of gender disparities, including horizontal and vertical segregation, the androcentric academic culture, and the gender pay gap. The authors warn of possible contamination of AI with human gender biases, which can be detrimental to academic hiring and assessment procedures. Summarizing gender-equality policies and practices available worldwide, the authors give recommendations on women's empowerment in HE&R on the global, national, and organizational levels.