scholarly journals Diabetic neovascularization defects in the retina are improved by genistein supplementation in the ovariectomized rat

2021 ◽  
Author(s):  
Hadi Yousefi ◽  
Alireza Komaki‬ ◽  
‬Siamak Shahidi ◽  
Parisa Habibi ◽  
Reihaneh Sadeghian ◽  
...  
Keyword(s):  
Ovariectomized Rat

Effects of quercetin, vitamin E, and estrogen on Metabolic-Related factors in uterus and serum of ovariectomized rat models

2021 ◽  
pp. 1-5
Author(s):  
Majid Jafari Khorchani ◽  
Mohammad Samare-Najaf ◽  
Ali Abbasi ◽  
Sina Vakili ◽  
Fatemeh Zal
Keyword(s):  
Vitamin E ◽  
Ovariectomized Rat ◽  
Related Factors ◽  
Rat Models

Effect of Intermittent and Daily Regimens of Minodronic Acid on Bone Metabolism in an Ovariectomized Rat Model of Osteoporosis

2014 ◽  
Vol 95 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Makoto Tanaka ◽  
Hiroshi Mori ◽  
Ryoji Kayasuga ◽  
Yasuo Ochi ◽  
Hiroyuki Yamada ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Minodronic Acid

Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat

1998 ◽  
Vol 274 (2) ◽  
pp. E328-E335 ◽  
Author(s):  
C. K. Lea ◽  
A. M. Flanagan
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Protective Effect ◽  
Cancellous Bone ◽  
Plasma Levels ◽  
Slow Release ◽  
Bone Volume ◽  
Ovariectomized Rat ◽  
Ovx Rats ◽  
Reduce Bone Loss

The effect of androstenedione (ADIONE) slow-release pellets on cancellous bone volume (BV/TV) at the tibial metaphysis was investigated in ovariectomized (OVX) rats at various times from 21 to 180 days. Plasma levels of ADIONE and testosterone (T) in OVX rats were significantly reduced at 21 days and were restored close to levels in the sham rats with the 1.5-mg ADIONE pellet. OVX animals with and without ADIONE pellets resulted in close to a 50% reduction in BV/TV by day 21. By day 180, OVX rats had only ∼5% BV/TV, whereas that in ADIONE-treated OVX rats was significantly greater at ∼12%. The reduced BV/TV was associated with increased bone resorption and formation. In a separate 90-day experiment, we found that the antiandrogen, Casodex, abrogated the ADIONE-induced skeletal-protective effect in OVX rats, whereas the antiaromatase, Arimidex, had no effect. This provides evidence that ADIONE protects against the development of osteopenia in the estrogen-deficient rat and mediates its effect through androgens and not estrogens.

scholarly journals Alfacalcidol enhances collagen quality in ovariectomized rat bones

2014 ◽  
Vol 32 (8) ◽  
pp. 1030-1036 ◽  
Author(s):  
Hideaki Nagaoka ◽  
Masahiko Terajima ◽  
Shizuka Yamada ◽  
Yoshiaki Azuma ◽  
Takayuki Chida ◽  
...  
Keyword(s):  
Ovariectomized Rat

The anti-osteoporotic effect of Yijung-tang in an ovariectomized rat model mediated by inhibition of osteoclast differentiation

2013 ◽  
Vol 146 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Taesoo Kim ◽  
Hyunil Ha ◽  
Ki-Shuk Shim ◽  
Won-Kyung Cho ◽  
Jin Yeul Ma
Keyword(s):  
Rat Model ◽  
Osteoclast Differentiation ◽  
Ovariectomized Rat

HORMONAL REQUIREMENTS FOR THE MAINTENANCE OF OESTRADIOL-INDUCED INHIBITION OF UTERINE SENSITIVITY IN THE OVARIECTOMIZED RAT

1970 ◽  
Vol 46 (3) ◽  
pp. 341-346 ◽  
Author(s):  
K. P. MEYERS
Keyword(s):  
Subcutaneous Injection ◽  
Ovariectomized Rats ◽  
Ovariectomized Rat ◽  
Single Subcutaneous Injection ◽  
The Third ◽  
Oestradiol Treatment ◽  
Progesterone Treatment ◽  
Endometrial Scratching

SUMMARY Ovariectomized rats treated with 2·5 or 5·0 mg. progesterone daily received a single subcutaneous injection of 0·2 μg. oestradiol on the third day of the progesterone treatment. The deciduomal response to trauma by endometrial scratching was used to determine the degree of uterine sensitivity at various times after oestradiol. Uterine sensitivity was partially and then completely lost 36 and 48 hr. after oestradiol administration. The inhibition of uterine sensitivity persisted until 9 and 11 days after oestradiol when the animals received 2·5 and 5·0 mg. progesterone daily. Uterine sensitivity was completely inhibited on day 11 with doses of oestradiol from 0·2 to 0·05 μg. Withdrawal of progesterone treatment for 48 or 72 hr., but not for 24 hr., after oestradiol treatment restored uterine sensitivity. These results show that the oestradiol-induced inhibition of uterine sensitivity in the progestational endometrium is maintained by continuous progesterone treatment and that the duration of this effect is dependent on the dose of progesterone given.

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