scholarly journals Correlation among Lens Opacities Classification System III grading, the 25-item National Eye Institute Visual Functioning Questionnaire, and Visual Function Index-14 for age-related cataract assessment

2020 ◽  
Vol 40 (7) ◽  
pp. 1831-1839
Author(s):  
Yu Wan ◽  
Yinhao Wang ◽  
Liming Zhao ◽  
Min Sun ◽  
Li An ◽  
...  
Keyword(s):  
Visual Function ◽  
Classification System ◽  
Visual Functioning ◽  
Function Index ◽  
Age Related ◽  
Lens Opacities

scholarly journals Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months

2019 ◽  
Vol 3 (8) ◽  
pp. 637-648 ◽  
Author(s):  
S. Tammy Hsu ◽  
Atalie C. Thompson ◽  
Sandra S. Stinnett ◽  
Ulrich F.O. Luhmann ◽  
Lejla Vajzovic ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Macular Degeneration ◽  
Visual Function ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Saumil Sethna ◽  
Patrick A. Scott ◽  
Arnaud P. J. Giese ◽  
Todd Duncan ◽  
Xiaoying Jian ◽  
...  
Keyword(s):  
Visual Function ◽  
Molecular Mechanisms ◽  
Neurodegenerative Disorder ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Negative Regulator ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Mtorc1 Signaling ◽  
Marked Accumulation

AbstractAge-related macular degeneration (AMD) is a multifactorial neurodegenerative disorder. Although molecular mechanisms remain elusive, deficits in autophagy have been associated with AMD. Here we show that deficiency of calcium and integrin binding protein 2 (CIB2) in mice, leads to age-related pathologies, including sub-retinal pigment epithelium (RPE) deposits, marked accumulation of drusen markers APOE, C3, Aβ, and esterified cholesterol, and impaired visual function, which can be rescued using exogenous retinoids. Cib2 mutant mice exhibit reduced lysosomal capacity and autophagic clearance, and increased mTORC1 signaling—a negative regulator of autophagy. We observe concordant molecular deficits in dry-AMD RPE/choroid post-mortem human tissues. Mechanistically, CIB2 negatively regulates mTORC1 by preferentially binding to ‘nucleotide empty’ or inactive GDP-loaded Rheb. Upregulated mTORC1 signaling has been implicated in lymphangioleiomyomatosis (LAM) cancer. Over-expressing CIB2 in LAM patient-derived fibroblasts downregulates hyperactive mTORC1 signaling. Thus, our findings have significant implications for treatment of AMD and other mTORC1 hyperactivity-associated disorders.

Relative Effects of Aging and Age-Related Macular Degeneration on Peripheral Visual Function

1997 ◽  
Vol 74 (3) ◽  
pp. 152-159 ◽  
Author(s):  
KAREN HOLOPIGIAN ◽  
WILLIAM SEIPLE ◽  
VIVIENNE GREENSTEIN ◽  
DANIEL KIM ◽  
RONALD E. CARR
Keyword(s):  
Macular Degeneration ◽  
Visual Function ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Effects Of Aging
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