En face optical coherence tomography patterns in patients with angiographically documented uveitic macular edema: a cross-sectional retrospective study

Aim: The aim of the study is to classify the patterns of uveitic macular edema using Optical Coherence Tomography as a diagnostic tool.Methodology: It is the Descriptive, cross-sectional study. All patients fulfilling the diagnostic criteria with Optical coherence tomography diagnosed macular edema were enrolled from 1 January 2012 to 30 June 2013. Patterns of uveitic macular edema were classified.Results: A total of 65 eyes of 47 patients were included. Twenty eight (59.57%) were male. The male to female ratio was 1.5:1. The mean age was 38 years (SD 14.68). Twenty nine patients (61.71%) had unilateral involvement and 18 (38.29%) had bilateral involvement. Forty five eyes of 33 cases (69.23%, 70.21%) had intermediate uveitis, followed by 10 eyes of 7 cases (15.38, 14.9%) of posterior uveitis, 6 eyes of 5 cases (9.23%, 10.63 %) of anterior uveitis and 4 eyes of 2 cases (6.16%,4.2%) of pan-uveitis. Patterns of macular edema were classified: diff use macular edema (DME), cystoid macular edema (CME) and serous retinal detachment (SRD) of which 35 (53.84%) eyes had CME. The etiological diagnosis was found in 7(14.90 %) out of 47 patients.Conclusion: A significant percentage of cases were idiopathic. Macular edema may go unnoticed unless OCT is performed. Macular detachment is an important feature of macular edema that affects visual acuity and is not readily detected by Fundus Fluorescein Angiography (FFA). Optical coherence tomography (OCT) is safe and non-invasive technique and has the potential for measuring changes in retinal thickness and axial extent of edema.

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En face image-based classification of diabetic macular edema using swept source optical coherence tomography

Scientific Reports ◽

10.1038/s41598-021-87440-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Atsushi Fujiwara ◽

Yuki Kanzaki ◽

Shuhei Kimura ◽

Mio Hosokawa ◽

Yusuke Shiode ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Outer Nuclear Layer ◽

Subretinal Fluid ◽

Plexiform Layer ◽

Optical Coherence ◽

Fiber Layer ◽

Swept Source ◽

En Face

AbstractThis retrospective study was performed to classify diabetic macular edema (DME) based on the localization and area of the fluid and to investigate the relationship of the classification with visual acuity (VA). The fluid was visualized using en face optical coherence tomography (OCT) images constructed using swept-source OCT. A total of 128 eyes with DME were included. The retina was segmented into: Segment 1, mainly comprising the inner nuclear layer and outer plexiform layer, including Henle’s fiber layer; and Segment 2, mainly comprising the outer nuclear layer. DME was classified as: foveal cystoid space at Segment 1 and no fluid at Segment 2 (n = 24), parafoveal cystoid space at Segment 1 and no fluid at Segment 2 (n = 25), parafoveal cystoid space at Segment 1 and diffuse fluid at Segment 2 (n = 16), diffuse fluid at both segments (n = 37), and diffuse fluid at both segments with subretinal fluid (n = 26). Eyes with diffuse fluid at Segment 2 showed significantly poorer VA, higher ellipsoid zone disruption rates, and greater central subfield thickness than did those without fluid at Segment 2 (P < 0.001 for all). These results indicate the importance of the localization and area of the fluid for VA in DME.

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Comparison of swept-source versus spectral-domain optical coherence tomography angiography for detection of macular neovascularization

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05229-6 ◽

2021 ◽

Author(s):

Anna Lentzsch ◽

Laura Schöllhorn ◽

Christel Schnorr ◽

Robert Siggel ◽

Sandra Liakopoulos

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Spectral Domain ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

En Face ◽

Increased Sensitivity ◽

Sensitivity Specificity ◽

Subretinal Hyperreflective Material

Abstract Purpose To compare swept-source (SS) versus spectral-domain (SD) optical coherence tomography angiography (OCTA) for the detection of macular neovascularization (MNV). Methods In this prospective cohort study, 72 eyes of 54 patients with subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye were included. OCTA scans were acquired using two devices, the PLEX Elite 9000 SS-OCTA and the Spectralis SD-OCTA. Fluorescein angiography (FA) was used as reference. Two graders independently evaluated en face OCTA images using a preset slab as well as a manually modified slab, followed by a combination of en face and cross-sectional OCTA. Results Sensitivity (specificity) for the automated slabs was 51.7% (93.0%) for SS-OCTA versus 58.6% (95.3%) for SD-OCTA. Manual modification of segmentation increased sensitivity to 79.3% for SS-OCTA but not for SD-OCTA (58.6%). The combination of en face OCTA with cross-sectional OCTA reached highest sensitivity values (SS-OCTA: 82.8%, SD-OCTA: 86.2%), and lowest number of cases with discrepancies between SS-OCTA and SD-OCTA (4.2%). Fleiss kappa as measure of concordance between FA, SS-OCTA, and SD-OCTA was 0.56 for the automated slabs, 0.60 for the manual slabs, and 0.73 (good agreement) for the combination of en face OCTA with cross-sectional OCTA. Concordance to FA was moderate for the automated slabs and good for manual slabs and combination with cross-sectional OCTA of both devices. Conclusion Both devices reached comparable results regarding the detection of MNV on OCTA. Sensitivity for MNV detection and agreement between devices was best when evaluating a combination of en face and cross-sectional OCTA.

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Fundus autofluorescence and spectral domain optical coherence tomography in uveitic macular edema

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-009-1149-8 ◽

2009 ◽

Vol 247 (12) ◽

pp. 1685-1689 ◽

Cited By ~ 25

Author(s):

Martin Roesel ◽

Andreas Henschel ◽

Carsten Heinz ◽

Martha Dietzel ◽

Georg Spital ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Fundus Autofluorescence ◽

Spectral Domain ◽

Optical Coherence ◽

Uveitic Macular Edema

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Topographic Analysis of Short Posterior Ciliary Arteries Using Wide-Field Swept-Source En-Face Optical Coherence Tomography

10.21203/rs.3.rs-151008/v1 ◽

2021 ◽

Author(s):

Raphael Lejoyeux ◽

Raphael Atia ◽

Kiran Vupparaboina ◽

Mohamed Ibrahim ◽

Jose-Alain Sahel ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Posterior Pole ◽

Wide Field ◽

Temporal Part ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Topographic Analysis ◽

En Face ◽

Ciliary Arteries

Abstract Purpose: To study the topographic distribution of the short posterior ciliary arteries (SPCA) entry sites into the choroid in normal eyes using structural en-face swept source optical coherence tomography (SS-OCT). Methods: Retrospective analysis of SS-OCT scans (wide-field structural SS-OCT 12x12mm) of 13 healthy subjects was performed. Cross-sectional swept-source OCT scans derived from a volume scan were represented as en-face image display following the Choroid-Scleral Interface to obtain en-face OCT. SPCAs in their last scleral location before choroidal entrance were identified manually, counted and localized by two masked observers. Correlations between two masked observers were analyzed using inter- and intra- class correlation. Results: Accuracy for the choroidal inner and outer border segmentation was 95-99%. Eighteen eyes from 13 normal subjects were included for SPCA analysis. The mean number of arteries was 13.8±3.5 per eye. Thirty-six percent were in the center of the posterior pole image; however, 21% were in the temporal part of the posterior pole. Median accuracy of the detection is 0.94. The correlation between the two observers was fair (0.54).Conclusion: Our algorithm allows visualization of the SPCA at the posterior pole of the eye using wide-field en-face SS-OCT. It can also help the clinicians to study the SPCAs in numerous ocular diseases, particularly its relationship with focal choroidal diseases.

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