Assessment of the toxicological profile of Chlorella (C. vulgaris) powder by performing acute and sub-acute oral toxicity studies in mice

2021 ◽  
Author(s):  
Mahendra Yadav ◽  
Pooja Sharma ◽  
Himanshu Kushwah ◽  
Nidhi Sandal ◽  
Meenakshi Kanwar Chauhan
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Toxicological Profile

scholarly journals Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit

2018 ◽  
Vol 12 (26) ◽  
pp. 389-396 ◽  
Author(s):  
Mengiste Berhan ◽  
Dires Kassahun ◽  
Lulekal Ermias ◽  
Arayaselassie Mahlet ◽  
Zenebe Tizazu ◽  
...  
Keyword(s):  
Essential Oils ◽  
Skin Irritation ◽  
Rosmarinus Officinalis ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

scholarly journals SYNTHESIS AND CHARACTERIZATION OF A NOVEL MUCOADHESIVE DERIVATIVE OF PSYLLIUM SEED POLYSACCHARIDE

2017 ◽  
Vol 9 (6) ◽  
pp. 166
Author(s):  
Monica R.p. Rao ◽  
Snehal R. Gaikwad ◽  
Prachi M. Shevate
Keyword(s):  
Retention Time ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Drug Release Profile ◽  
Toxicity Studies ◽  
Percent Increase ◽  
Human Use ◽  
Ellman’S Method ◽  
Thiol Functionalization

Objective: In the present study, thiol-functionalization of psyllium seed polysaccharide (PSY) was cross-linked with thioglycolic acid by esterification in an attempt to reveal the mucoadhesive properties of thiolated psyllium seed polysaccharide (TPSY).Methods: The crosslinking was carried out by the microwave-assisted method. A simplex centroid design was employed to systematically study the mucoadhesive strength, mucoadhesive retention time and drug release profile. Comparative evaluation of carbopol-based ciprofloxacin hydrochloride (HCl) tablets containing PSY and TPSY was carried out. Acute oral toxicity studies and repeated oral toxicity for TPSY were also conducted.Results: Thiol-functionalization was confirmed by-SH stretch in Fourier Transform infra-red spectra at 2353 cm-1. Thiolation was observed in thiolated PSY (TPSY) by a change in the surface morphology of psyllium from fibrous to granular and resulted in 82 %swelling in deionized water. TPSY was found to contain 102.35 mmol of thiol groups/g as determined by the Ellman’s method. The percent increase in mucoadhesive strength of TPSY was found to be 50.31 % as compared to PSY and 128.30 % as compared to carbopol. The percent increase in mucoadhesive retention time of TPSY was found to be 110 % as compared to PSY and 50 % as compared to carbopol.Conclusion: Mucoadhesion strength and mucoadhesive retention time were greater of tablets containing a higher amount of TPSY. Further, the acute oral toxicity studies and repeated oral toxicity for TPSY proved it as non-toxic and hence safe for human use.

Acute and sub-acute oral toxicity studies of standardized extract of Nasturtium officinale in Wistar rats

2019 ◽  
Vol 108 ◽  
pp. 104443 ◽  
Author(s):  
M. Clemente ◽  
M.D. Miguel ◽  
K.B. Felipe ◽  
C. Gribner ◽  
P.F. Moura ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Nasturtium Officinale ◽  
Toxicity Studies

Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles

2019 ◽  
Vol 107 ◽  
pp. 104426 ◽  
Author(s):  
Chia-Hung Liu ◽  
Hsien-Chun Chiu ◽  
Hsiang-Ling Sung ◽  
Jyun-Yi Yeh ◽  
Kevin C.-W. Wu ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

Evaluation and solubility improvement of Carvedilol: PSC[n]arene inclusion complexes with acute oral toxicity studies

2011 ◽  
Vol 73 (1-4) ◽  
pp. 295-303 ◽  
Author(s):  
Shobhana K. Menon ◽  
Bhoomika R. Mistry ◽  
Kuldeep V. Joshi ◽  
Nishith R. Modi ◽  
Divyesh Shashtri
Keyword(s):  
Inclusion Complexes ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Solubility Improvement

scholarly journals Antitumor Effects and Acute Oral Toxicity Studies of a Plant Extract Mixture Containing <i>Rhus verniciflua</i> and Some Other Herbs

2015 ◽  
Vol 05 (01) ◽  
pp. 39-49 ◽  
Author(s):  
Wataru Hiruma ◽  
Kohei Suruga ◽  
Kazunari Kadokura ◽  
Tsuyoshi Tomita ◽  
Ayaka Miyata ◽  
...  
Keyword(s):  
Plant Extract ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Antitumor Effects ◽  
Toxicity Studies ◽  
Rhus Verniciflua
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