Acute oral toxicity studies of methanolic extract and chloroform fraction of methanolic extract of seeds of muricata

2020 ◽  
Vol 16 (72) ◽  
pp. 762
Author(s):  
BibuJohn Kariyil ◽  
PT A. Usha
Keyword(s):  
Methanolic Extract ◽  
Chloroform Fraction ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

scholarly journals Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract

2010 ◽  
Vol 2 (4) ◽  
pp. 215 ◽  
Author(s):  
Sreenivasan Sasidharan ◽  
Mohd. Nizam Mordi ◽  
Sabariah Ismail ◽  
SharifMahsufi Mansor ◽  
Geethaa Sahgal ◽  
...  
Keyword(s):  
Brine Shrimp ◽  
Methanolic Extract ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Brine Shrimp Lethality ◽  
Toxicity Studies ◽  
Swietenia Mahagoni

Acute oral toxicity studies of the standardized methanolic extract of Phyllanthus amarus Schum & Thonn

2013 ◽  
Vol 6 (7) ◽  
pp. 720-724 ◽  
Author(s):  
S.K. Kushwaha ◽  
A. Dashora ◽  
N. Dashora ◽  
J.R. Patel ◽  
M.L. Kori
Keyword(s):  
Methanolic Extract ◽  
Phyllanthus Amarus ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

Assessment of the toxicological profile of Chlorella (C. vulgaris) powder by performing acute and sub-acute oral toxicity studies in mice

2021 ◽  
Author(s):  
Mahendra Yadav ◽  
Pooja Sharma ◽  
Himanshu Kushwah ◽  
Nidhi Sandal ◽  
Meenakshi Kanwar Chauhan
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Toxicological Profile

scholarly journals Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit

2018 ◽  
Vol 12 (26) ◽  
pp. 389-396 ◽  
Author(s):  
Mengiste Berhan ◽  
Dires Kassahun ◽  
Lulekal Ermias ◽  
Arayaselassie Mahlet ◽  
Zenebe Tizazu ◽  
...  
Keyword(s):  
Essential Oils ◽  
Skin Irritation ◽  
Rosmarinus Officinalis ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

scholarly journals SYNTHESIS AND CHARACTERIZATION OF A NOVEL MUCOADHESIVE DERIVATIVE OF PSYLLIUM SEED POLYSACCHARIDE

2017 ◽  
Vol 9 (6) ◽  
pp. 166
Author(s):  
Monica R.p. Rao ◽  
Snehal R. Gaikwad ◽  
Prachi M. Shevate
Keyword(s):  
Retention Time ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Drug Release Profile ◽  
Toxicity Studies ◽  
Percent Increase ◽  
Human Use ◽  
Ellman’S Method ◽  
Thiol Functionalization

Objective: In the present study, thiol-functionalization of psyllium seed polysaccharide (PSY) was cross-linked with thioglycolic acid by esterification in an attempt to reveal the mucoadhesive properties of thiolated psyllium seed polysaccharide (TPSY).Methods: The crosslinking was carried out by the microwave-assisted method. A simplex centroid design was employed to systematically study the mucoadhesive strength, mucoadhesive retention time and drug release profile. Comparative evaluation of carbopol-based ciprofloxacin hydrochloride (HCl) tablets containing PSY and TPSY was carried out. Acute oral toxicity studies and repeated oral toxicity for TPSY were also conducted.Results: Thiol-functionalization was confirmed by-SH stretch in Fourier Transform infra-red spectra at 2353 cm-1. Thiolation was observed in thiolated PSY (TPSY) by a change in the surface morphology of psyllium from fibrous to granular and resulted in 82 %swelling in deionized water. TPSY was found to contain 102.35 mmol of thiol groups/g as determined by the Ellman’s method. The percent increase in mucoadhesive strength of TPSY was found to be 50.31 % as compared to PSY and 128.30 % as compared to carbopol. The percent increase in mucoadhesive retention time of TPSY was found to be 110 % as compared to PSY and 50 % as compared to carbopol.Conclusion: Mucoadhesion strength and mucoadhesive retention time were greater of tablets containing a higher amount of TPSY. Further, the acute oral toxicity studies and repeated oral toxicity for TPSY proved it as non-toxic and hence safe for human use.

Acute and sub-acute oral toxicity studies of standardized extract of Nasturtium officinale in Wistar rats

2019 ◽  
Vol 108 ◽  
pp. 104443 ◽  
Author(s):  
M. Clemente ◽  
M.D. Miguel ◽  
K.B. Felipe ◽  
C. Gribner ◽  
P.F. Moura ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Nasturtium Officinale ◽  
Toxicity Studies

Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles

2019 ◽  
Vol 107 ◽  
pp. 104426 ◽  
Author(s):  
Chia-Hung Liu ◽  
Hsien-Chun Chiu ◽  
Hsiang-Ling Sung ◽  
Jyun-Yi Yeh ◽  
Kevin C.-W. Wu ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

Evaluation and solubility improvement of Carvedilol: PSC[n]arene inclusion complexes with acute oral toxicity studies

2011 ◽  
Vol 73 (1-4) ◽  
pp. 295-303 ◽  
Author(s):  
Shobhana K. Menon ◽  
Bhoomika R. Mistry ◽  
Kuldeep V. Joshi ◽  
Nishith R. Modi ◽  
Divyesh Shashtri
Keyword(s):  
Inclusion Complexes ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Solubility Improvement
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