Physicochemical characterization of finasteride:PEG 6000 and finasteride:Kollidon K25 solid dispersions, and finasteride: β-cyclodextrin inclusion complexes

2010 ◽  
Vol 70 (3-4) ◽  
pp. 397-406 ◽  
Author(s):  
Hugo M. Almeida ◽  
Helena M. Cabral Marques
1991 ◽  
Vol 37 (11-12) ◽  
pp. 2497-2506 ◽  
Author(s):  
P. Cloudy ◽  
J. M. Létoffé ◽  
P. Germain ◽  
J. P. Bastide ◽  
A. Bayol ◽  
...  

2009 ◽  
Vol 10 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Sateeshkumar Sathigari ◽  
Gurkishan Chadha ◽  
Y-H. Phillip Lee ◽  
Nydeia Wright ◽  
Daniel L. Parsons ◽  
...  

2005 ◽  
Vol 3 (2) ◽  
pp. 151-155
Author(s):  
Goran Petrovic ◽  
Blaga Stojceva-Radovanovic ◽  
O. Jovanovic

The solubility of four different pesticides, "dimethoate", "simazine" "linuron" and "thiram", poorly soluble or non-soluble in water, were measured in water and in aqueous solution of ?-cyclodextrin by ultraviolet spectrophotometry. Standard water solutions of pesticides were prepared in the range of concentrations up to the maximum solubility of each pesticide in water. Concentrations of the pesticides were determined as absorbance on the absorption maximum. The obtained results show that the aqueous solution of ?-cyclodextrin was a powerful solubilizer of investigated pesticides due to the formation of inclusion complexes. Effective solubility of some of the pesticides in aqueous ?-cyclodextrin solution was up to three orders of magnitude higher than those in water. Thermodynamic parameters and complex stability constant of the obtained inclusion complexes were determined by the calorimetric measurements.


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