scholarly journals Congenital Hypothyroidism Long-Term Follow-up Project: Navigating the Rough Waters of a Multi-Center, Multi-State Public Health Project

2014 ◽  
Vol 24 (3) ◽  
pp. 464-472 ◽  
Author(s):  
Kupper Wintergerst ◽  
Gina Gembel ◽  
Tracey Kreipe ◽  
Patrick Zeller ◽  
Erica Eugster ◽  
...  
Keyword(s):  
Public Health ◽  
Congenital Hypothyroidism ◽  
Long Term Follow Up ◽  
Health Project

Treatment of Congenital Hypothyroidism: Comparison Between L-Thyroxine Oral Solution and Tablet Formulations up to 3 years of age

2021 ◽  
Author(s):  
Maria Cristina Vigone ◽  
Rita Ortolano ◽  
Gaia Vincenzi ◽  
Clara Pozzi ◽  
Micol Ratti ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Oral Solution ◽  
Negative Effects ◽  
Developmental Quotient ◽  
Long Term Follow Up ◽  
Tablet Formulations ◽  
Hand Coordination ◽  
Group D

Objective. Oral solution and tablet formulations of Levo-Thyroxine (L-T4) are both used in the treatment of Congenital Hypothyroidism (CH). However, few studies and with a limited follow-up period have been published comparing these two formulations in children. Design. The aim of this multicenter study was to compare the effectiveness of L-T4 oral solution (with ethanol as excipient) and tablet formulation in children with CH up to 3 years of age. Methods. Children diagnosed with CH between 2006 and 2015 were enrolled and divided into two groups according to the L-T4 formulation used: solution in drops (Group D) or tablets (Group T). Auxological parameters, TSH and FT4 values and L-T4 dose were collected at diagnosis and at 15 days, 1, 3, 6, 12, 24 and 36 months of treatment. The Developmental Quotient at 1 and 3 years of age was evaluated using Griffiths’ Scale. Results. 254 children were enrolled. 117 were treated with solution and 137 with tablets. Auxological parameters, dose and thyroid function values at diagnosis, 3, 6, 12, 24, 36 months were not significantly different. TSH at 15 days (p=0.002) and 1 month (p=0.009) was significantly reduced in group D. At 2-year follow-up, median TSH was significantly lower in group T (p=0.03). No statistical difference was detected between the median Developmental Quotient, however group D showed lower values in the language subscale at 12 months and in eye-hand coordination at 36 months. Conclusions. Both therapeutic strategies are effective on treatment of CH. A higher risk of overtreatment in the first months of therapy seems to be associated with oral solution L-T4; therefore, a different strategy should be considered when starting and adjusting the dose. No negative effects in cognitive development were observed. The data obtained are encouraging but long-term follow-up is needed.

Long‐Term Follow‐up of the Mind Your Health Project: Acceptance‐Based versus Standard Behavioral Treatment for Obesity

Obesity ◽  
2019 ◽  
Vol 27 (4) ◽  
pp. 565-571 ◽  
Author(s):  
Evan M. Forman ◽  
Stephanie M. Manasse ◽  
Meghan L. Butryn ◽  
Ross D. Crosby ◽  
Diane H. Dallal ◽  
...  
Keyword(s):  
Behavioral Treatment ◽  
Long Term Follow Up ◽  
Health Project ◽  
The Mind

Treatment Strategy and Long Term Follow Up of Congenital Hypothyroidism

1989 ◽  
pp. 245-252 ◽  
Author(s):  
G. Van Vliet ◽  
Th. Barboni ◽  
M. Klees ◽  
F. Cantraine ◽  
R. Wolter
Keyword(s):  
Congenital Hypothyroidism ◽  
Treatment Strategy ◽  
Long Term Follow Up

scholarly journals The new public health imposed and its missing links - people, cultures, anthropology, health for all

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Špoljar Vržina
Keyword(s):  
Public Health ◽  
The Public ◽  
New Public Health ◽  
New Public ◽  
Entry Points ◽  
Long Term Follow Up ◽  
Critical Medical Anthropology ◽  
Health Agenda

Abstract Critical medical anthropology has been active throughout the decades (Baer, Susser, Singer 1986; Lock, Nichter, 2002; Lupton, 1995. 2000, 2015) in proving that public health is not only an addition to equations of equity in health care but rooted in cultures of people globally (Špoljar Vržina 2003, 2007, 2008; 2011, 2013, 2021; Špoljar Vržina, Rudan, 2009). Italian anthropologist codified the postmodern 'doing good only in states of emergencies' (Pandolfi, 2010). In times of Corona Covid 19 -2020 epidemiological freights we are urged to take this further into account, especially since witnessing racial stigmatizing on the basis of ethnicity and nationality. Paradoxically, Italy as one of the cradles of quarantines is facing the potential permanent closure of neighbouring borders rather than experiencing a historically practiced cooperation, as in the case with Croatia, over centuries (Blažina, Blažina 2015). If there should be a New Public Health (Baum 2016, 2019; Lupton 1997, 2000) it should be recalibrated by anthropological findings that re- focus towards the good of people, cultures and their cooperation. The work of this paper presents this urgent challenge. This anthropological research is a long-term follow up of Croatian medicine system dismantling (Špoljar Vržina, 2008 onwards) through a continuous analyses of micro (people), intermediary (governmental) and macro (international) changes (Bear et al. 1986), departures from functioning for the benefit of people and finding entry points for ethical corrective interventions. The analysis proved an existing switch of the public health paradigm from global health into states of neoliberal sickness, with clear possibilities of returning to 'health for all' if disengaging from the politics of culture/public health. Public health enhancements need to be based on the recalibration towards knowledges of populational and cultural realities. Key messages Reintroducing the ‘innovative’ wisdom of doing good for all regardless of emergencies is the core of a new public health agenda. The new public health agenda is based on recognizing cultures as pillars of communities and global societies that matter.

scholarly journals Long Term Follow-Up of Borderline Congenital Hypothyroidism † 409

1998 ◽  
Vol 43 ◽  
pp. 73-73
Author(s):  
A Daliva ◽  
B Linder ◽  
J Martino-Nardi ◽  
P Saenger
Keyword(s):  
Congenital Hypothyroidism ◽  
Long Term Follow Up

scholarly journals Neonatal Screening for Congenital Hypothyroidism: What Can We Learn From Discordant Twins?

2019 ◽  
Vol 104 (12) ◽  
pp. 5765-5779 ◽  
Author(s):  
Emanuela Medda ◽  
Maria Cristina Vigone ◽  
Alessandra Cassio ◽  
Francesca Calaciura ◽  
Pietro Costa ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Congenital Hypothyroidism ◽  
Screening Program ◽  
Phenotypic Variance ◽  
Fetal Life ◽  
Long Term Follow Up ◽  
Discordant Twins ◽  
Discordant Twin

Abstract Context Newborn screening program for congenital hypothyroidism (CH) adopting rescreening in at-risk neonates. Objectives To estimate the concordance rate for CH in twin pairs discordant at the first screening; to verify whether long-term follow-up of healthy cotwins belonging to CH discordant pairs may be useful to diagnose thyroid hypofunction during development; to evaluate the importance of genetic and environmental influences on liability to permanent and transient CH. Design and Patients Forty-seven screening discordant twin pairs were investigated. Proband was defined as the twin in the pair with a positive test at the first screening and a confirmed diagnosis of CH. Results Seven screening discordant twin pairs became concordant for CH within the first month of life (pairwise concordance of 14.9%) because seven screening negative cotwins showed high TSH values when retested. During long-term follow-up (range, 3 to 21 years), hypothyroidism was diagnosed in two monozygotic screening negative cotwins at the age of 9 months and 12 years, respectively. Furthermore, the twin analysis showed that 95% of liability to transient CH was explained by genetic factors and 5% by environmental (unshared) factors, whereas 64% of phenotypic variance of permanent CH was explained by common environmental factors (shared during the fetal life) and 36% by unshared environmental factors. Conclusions This study showed that the introduction of rescreening permits the diagnosis of CH in a greater number of twins. It also showed the importance of long-term follow-up in both twins in the pair, and the role of nongenetic factors in the etiology of permanent CH.

Sign in / Sign up

Export Citation Format

Share Document