Metabolic pathway analysis using a nash equilibrium approach

2018 ◽  
Vol 71 (3) ◽  
pp. 537-550 ◽  
Author(s):  
Angelo Lucia ◽  
Peter A. DiMaggio ◽  
Diego Alonso-Martinez
Keyword(s):  
Nash Equilibrium ◽  
Pathway Analysis ◽  
Metabolic Pathway ◽  
Metabolic Pathway Analysis ◽  
Equilibrium Approach

scholarly journals Modeling Energy Depletion in Rat Livers Using Nash Equilibrium Metabolic Pathway Analysis

2021 ◽  
Author(s):  
Angelo Lucia ◽  
Emily Ferrarese ◽  
Korkut Uygun
Keyword(s):  
Experimental Data ◽  
Nash Equilibrium ◽  
Pathway Analysis ◽  
Cold Storage ◽  
Metabolic Pathway ◽  
Energy Charge ◽  
Model Parameters ◽  
Metabolic Pathway Analysis ◽  
Energy Depletion ◽  
University Of Wisconsin

Abstract The current gold standard of Static Cold Storage (SCS), which is static cold storage on ice (about +4°C) in a specialized media such as the University of Wisconsin solution (UW), limits storage to few hours for vascular and metabolically active tissues such as the liver and the heart. The liver is arguably the pinnacle of metabolism in human body and therefore metabolic pathway analysis immediately becomes very relevant. In this article, a Nash Equilibrium (NE) approach, which is a first principles approach, is used to model and simulate the static cold storage of a proposed model of liver cells. Simulations of energy depletion in the liver in static cold storage measured by ATP content and energy charge are presented along with comparisons to experimental data. In addition, conversion of Nash Equilibrium iterations to time are described along with an uncertainty analysis for the parameters in the model. Results in this work show that the Nash Equilibrium approach provides a good match to experimental data for energy depletion and that the uncertainty in model parameters is very small with percent variances less than 0.1%.

scholarly journals PySCeSToolbox: a collection of metabolic pathway analysis tools

2017 ◽  
Vol 34 (1) ◽  
pp. 124-125 ◽  
Author(s):  
Carl D Christensen ◽  
Jan-Hendrik S Hofmeyr ◽  
Johann M Rohwer
Keyword(s):  
Pathway Analysis ◽  
Metabolic Pathway ◽  
Metabolic Pathway Analysis ◽  
Analysis Tools

Toward Genome-Scale Metabolic Pathway Analysis

2016 ◽  
pp. 111-123 ◽  
Author(s):  
Jürgen Zanghellini ◽  
Matthias P. Gerstl ◽  
Michael Hanscho ◽  
Govind Nair ◽  
Georg Regensburger ◽  
...  
Keyword(s):  
Pathway Analysis ◽  
Metabolic Pathway ◽  
Metabolic Pathway Analysis ◽  
Genome Scale
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