e12544 Background: Hispanics are less likely to undergo colorectal cancer and cervical cancer screening tests than non-Hispanic population. We address the barriers for compliance in a Hispanic community. Methods: A descriptive study was performed with 194 patients between 21 to 85 y/o, while they attended routine medical encounters at a private and a government sponsored clinics. Compliance and barriers for non compliance for mammography (MAMMO), occult blood testing (FOBT), colonoscopy (COLO) and cervical smears (Pap) were studied. Univariate and bivariate tests were used. Results: Females (62.9%) had a mean age of 53.4 ±15.0; had a high school diploma or higher degree (80.5%), unemployed (52.15), had private health insurance (68.0%), and practiced routine medical checkups (79.9%). Gender differences for patients undergoing FOBT and COLO were found only in patients older than 50 y/o. Females were more likely than males to undergo COLO (62.3% vs. 42.2%; p<0.05) whereas males are more likely than females to had a FOBT (66.7% vs. 56.5%; p>0.05). Differences between employed and unemployed patients undergoing FOBT were seen (48.4% vs. 65.1%; p=0.105) and COLO (38.7% vs. 60.2%; p=0.040). Seventy four percent of women between 40 to 65 y/o had a Pap and 85% had a MAMMO. Predominant reasons for avoiding MAMMO and Pap were fear (20%; p<0.05 and 6%; p>0.05), uncomfortable sensation (13%; p<0.05 and 19%; p<0.05), lack of time (67%; p<0.0001 and 56%; p<0.0001). Reasons for avoiding FOBT and COLO were not recommended by physician (42%; p<0.05 and 52%; p>0.05) and lack of knowledge (16%; p<0.05 and 17%; p<0.05). Conclusions: Occupational status in women (p<0.05) was found as a barrier for compliance with screening MAMMO, while it was also a barrier for COLO in both men and female over the age of 50. (p<0.05) Educational level in men and women was not associated with non compliance with FOBT or COLO in patients older than 50 y/o. Having a private health insurance is a predictor of compliance with MAMMO (71.3%), FOBT (78.3%), COLO (80.6%), and Pap (68.6%). Several physician and patient related factors were identified as barriers for compliance. Study was supported by NIH grant #'s 8U54MD007587 & 8G12MD007583.