scholarly journals Efficient Semidefinite Programming with Approximate ADMM

Author(s):  
Nikitas Rontsis ◽  
Paul Goulart ◽  
Yuji Nakatsukasa

AbstractTenfold improvements in computation speed can be brought to the alternating direction method of multipliers (ADMM) for Semidefinite Programming with virtually no decrease in robustness and provable convergence simply by projecting approximately to the Semidefinite cone. Instead of computing the projections via “exact” eigendecompositions that scale cubically with the matrix size and cannot be warm-started, we suggest using state-of-the-art factorization-free, approximate eigensolvers, thus achieving almost quadratic scaling and the crucial ability of warm-starting. Using a recent result from Goulart et al. (Linear Algebra Appl 594:177–192, 2020. https://doi.org/10.1016/j.laa.2020.02.014), we are able to circumvent the numerical instability of the eigendecomposition and thus maintain tight control on the projection accuracy. This in turn guarantees convergence, either to a solution or a certificate of infeasibility, of the ADMM algorithm. To achieve this, we extend recent results from Banjac et al. (J Optim Theory Appl 183(2):490–519, 2019. https://doi.org/10.1007/s10957-019-01575-y) to prove that reliable infeasibility detection can be performed with ADMM even in the presence of approximation errors. In all of the considered problems of SDPLIB that “exact” ADMM can solve in a few thousand iterations, our approach brings a significant, up to 20x, speedup without a noticeable increase in ADMM’s iterations.

Reproduction ◽  
2017 ◽  
Vol 153 (6) ◽  
pp. 847-863 ◽  
Author(s):  
Wan-Sheng Liu ◽  
Yaqi Zhao ◽  
Chen Lu ◽  
Gang Ning ◽  
Yun Ma ◽  
...  

Preferentially expressed antigen in melanoma (PRAME) is a cancer/testis antigen that is predominantly expressed in normal testicular tissues and a variety of tumors. The function of the PRAME family in spermatogenesis remains unknown. This study was designed to characterize the Y-linked PRAME (PRAMEY) protein during spermatogenesis in cattle. We found that PRAMEY is a novel male germ cell-specific, and a germinal granule-associated protein that is expressed in spermatogenic cells during spermatogenesis. The intact PRAMEY protein (58 kDa) was detected in different ages of testes but not in epididymal spermatozoa. A PRAMEY isoform (30 kDa) was highly expressed only in testes after puberty and in epididymal spermatozoa. This isoform interacts with PP1γ2 and is likely the mature protein present in the testes and sperm. Immunofluorescent staining demonstrated that PRAMEY was located predominantly in the acrosome granule of spermatids, and in acrosome and flagellum of spermatozoa. Immunogold electron microscopy further localized the PRAMEY protein complex to the nucleus and several cytoplasmic organelles, including the rough endoplasmic reticulum, some small vesicles, the intermitochondrial cement, the chromatoid body and the centrioles, in spermatogonia, spermatocytes, spermatids and/or spermatozoa. PRAMEY was highly enriched in and structurally associated with the matrix of the acrosomal granule (AG) in round spermatids, and migrated with the expansion of the AG during acrosomal biogenesis. While the function of PRAMEY remains unclear during spermatogenesis, our results suggest that PRAMEY may play an essential role in acrosome biogenesis and spermatogenesis.Free Chinese abstract: A Chinese translation of this abstract is freely available athttp://www.reproduction-online.org/content/153/6/847/suppl/DC2Spanish abstract: A Spanish translation of this abstract is freely available athttp://www.reproduction-online.org/content/153/6/847/suppl/DC3


2007 ◽  
Vol 7 (12) ◽  
pp. 4456-4464 ◽  
Author(s):  
S. M. L. Silva ◽  
M. A. López-Manchado ◽  
M. Arroyo

The effect of different nanofillers and compatibilizers (maleic anhydride-grafted-polypropylene and maleic anhydride-grafted-ethylene propylene diene terpolymer rubber) on the morphology, mechanical, mechanodynamical and thermal characteristics of thermoplastic olefins based on polypropylene and ethylene propylene diene terpolymer rubber blends has been analysed. A better affinity with the matrix and a better dispersion of the nanoparticles is observed in rubber rich matrices. Organoclay, such as Cloisite C15A and Cloisite C20A, treated with a non-polar surfactant give rise to intercalated nanocomposites, and the lower the concentration of surfactant (C20A) the most noticeable increase in interlayer spacing and consequently better properties in the nanocomposites. The maleic anhydride-grafted-ethylene propylene diene terpolymer rubber is a better compatibilizer for organo-clay nanocomposites based on rubber rich matrices.


Author(s):  
Gábor Hetyei

We show how Viennot’s combinatorial theory of orthogonal polynomials may be used to generalize some recent results of Sukumar and Hodges (Hodges & Sukumar 2007 Proc. R. Soc. A 463 , 2401–2414 ( doi:10.1098/rspa.2007.0001 ); Sukumar & Hodges 2007 Proc. R. Soc. A 463 , 2415–2427 ( doi:10.1098/rspa.2007.0003 )) on the matrix entries in powers of certain operators in a representation of su(1, 1). Our results link these calculations to finding the moments and inverse polynomial coefficients of certain Laguerre polynomials and Meixner polynomials of the second kind. As an immediate consequence of results by Koelink, Groenevelt and Van Der Jeugt (Van Der Jeugt 1997 J. Math. Phys. 38 , 2728–2740 ( doi:10.1063/1.531984 ); Koelink & Van Der Jeugt 1998 SIAM J. Math. Anal. 29 , 794–822 ( doi:10.1137/S003614109630673X ); Groenevelt & Koelink 2002 J. Phys. A 35 , 65–85 ( doi:10.1088/0305-4470/35/1/306 )), for the related operators, substitutions into essentially the same Laguerre polynomials and Meixner polynomials of the second kind may be used to express their eigenvectors. Our combinatorial approach explains and generalizes this ‘coincidence’.


2020 ◽  
Author(s):  
Georgios Nikolopoulos ◽  
Claire E. L. Smith ◽  
James A. Poulter ◽  
Gina Murillo ◽  
Sandra Silva ◽  
...  

AbstractAmelogenesis imperfecta (AI) describes a heterogeneous group of developmental enamel defects that typically have Mendelian inheritance. Exome sequencing of ten families with recessive hypomaturation AI revealed 4 novel and 1 known variants in the matrix metallopeptidase 20 (MMP20) gene that were predicted to be pathogenic. MMP20 encodes a protease that cleaves the developing extracellular enamel matrix and is necessary for normal enamel crystal growth during amelogenesis. New homozygous missense changes were shared between four families of Pakistani heritage (c.625G>C; p.(E209Q)) and two of Omani origin (c.710C>A; p.(S237Y)). In two families of UK origin and one from Costa Rica, affected individuals were homozygous for the previously reported c.954-2A>T; p.(I319Ffs*19) variant. For each of these variants, microsatellite haplotypes appeared to exclude a recent founder effect, but elements of haplotype were conserved, suggesting more distant founding ancestors. New compound heterozygous changes were identified in one family of European heritage; c.809_811+12delACGgtaagattattainsCCAG; p.(?) and c.1122A>C; p.(Q374H). All four new variants are within the zinc dependant peptidase domain. This report further elucidates the mutation spectrum of MMP20 and the probable impact on protein function, confirms a consistent hypomaturation phenotype and shows that mutations in MMP20 are a common cause of autosomal recessive AI in some communities.Data AvailabilityThe data that support the findings of this study are openly available in ClinVar at https://www.ncbi.nlm.nih.gov/clinvar/, accession numbers: SCV001338799 - SCV001338802 and in the AI Leiden Open Variation Database (LOVD) at http://dna2.leeds.ac.uk/LOVD/ with reference numbers: 0000000313 – 0000000317.


2017 ◽  
Author(s):  
Saleh Alzahrani ◽  
Charles W Anderson

Objective: The P300 signal is an electroencephalography (EEG) positive deflection observed 300 ms to 600 ms after an infrequent, but expected, stimulus is presented to a subject. The aim of this study was to investigate the capability of Emotiv EPOC+ headset to capture and record the P300 wave. Moreover, the effects of using different matrix sizes, flash duration, and colors were studied. Methods: Participants attended to one cell of either 6x6 or 3x3 matrix while the rows and columns flashed randomly at different duration (100 ms or 175 ms). The EEG signals were sent wirelessly to OpenViBE software, which is used to run the P300 speller. Results: The results provide evidence of capability of the Emotiv EPOC+ headset to detect the P300 signals from two channels, O1 and O2. In addition, when the matrix size increases, the P300 amplitude increases. The results also show that longer flash duration resulted in larger P300 amplitude. Also, the effect of using colored matrix was clear on the O2 channel. Furthermore, results show that participants reached accuracy above 70% after three to four training sessions. Conclusion: The results confirmed the capability of the Emotiv EPOC+ headset for detecting P300 signals. In addition, matrix size, flash duration, and colors can affect the P300 speller performance. Significance: Such an affordable and portable headset could be utilized to control P300-based BCI or other BCI systems especially for the out-of-the-lab applications.


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