Ionic current conduction at low voltage of track-etched double conical nanopores modified by surfactant CTAB

2020 ◽  
Vol 27 (11) ◽  
Author(s):  
XiaoRui Zhu ◽  
Lin Wang ◽  
CeMing Wang ◽  
YuGang Wang
Keyword(s):  
Low Voltage ◽  
Ionic Current ◽  
Conical Nanopores ◽  
Current Conduction

Effect of linear surface-charge non-uniformities on the electrokinetic ionic-current rectification in conical nanopores

2009 ◽  
Vol 329 (2) ◽  
pp. 376-383 ◽  
Author(s):  
Shizhi Qian ◽  
Sang W. Joo ◽  
Ye Ai ◽  
Marcos A. Cheney ◽  
Wensheng Hou
Keyword(s):  
Surface Charge ◽  
Ionic Current ◽  
Conical Nanopores ◽  
Current Rectification

scholarly journals Design and Fabrication of a Micropump With Mixing Function for LOC

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
Ho-jin Kang ◽  
Bum-kyoo Choi
Keyword(s):  
Lorentz Force ◽  
High Speed ◽  
Low Voltage ◽  
Flow Direction ◽  
Ionic Current ◽  
Digital Camera ◽  
Working Medium ◽  
Electrode Length ◽  
Portable System ◽  
Phosphate Buffered Saline

A micropump, which includes a mixing function, has been fabricated. For the application to LOC (Lab On a chip), the micropump utilized PBS (Phosphate Buffered Saline) solution as the working medium. The solution is commonly used in biochemistry and cell culturing. The portable system and low energy consumption are important to realize the LOC device. In spite of a low voltage of 4V, the flow rate of the micropump was 0.02466ml∕min. The new micropump shows more enhanced performance than existing micropumps. The micropump uses Lorentz force actuation. The Lorentz force acting onto the ionic current in the PBS solution generates the fluid flow in the micropump. For the accurate prediction on flow direction, a computer simulation has been made using commercial CFD code. The results of simulation showing circulation direction were verified by experiment. The fluid circulation from each electrode combined and acted as the mixer in the micropump. The micropump was fabricated 20.2mm in length, 1mm in width and 400 μm in electrode length. To measure accurately, a high speed digital camera was used.

scholarly journals Impact of Polyelectrolyte Multilayers on the Ionic Current Rectification of Conical Nanopores

Langmuir ◽  
2018 ◽  
Vol 34 (11) ◽  
pp. 3405-3412 ◽  
Author(s):  
Tianji Ma ◽  
Paulius Gaigalas ◽  
Mathilde Lepoitevin ◽  
Ieva Plikusiene ◽  
Mikhael Bechelany ◽  
...  
Keyword(s):  
Ionic Current ◽  
Polyelectrolyte Multilayers ◽  
Conical Nanopores ◽  
Current Rectification

scholarly journals Ionic Current Rectification in Track-Etched Single Conical Nanopores

2019 ◽  
pp. 225-234
Author(s):  
Dürdane Yilmaz ◽  
Dila Kaya ◽  
Kaan Keçeci ◽  
Ali Dinler
Keyword(s):  
Ionic Current ◽  
Conical Nanopores ◽  
Current Rectification

Effects of Electroosmotic Flow on Ionic Current Rectification in Conical Nanopores

2010 ◽  
Vol 114 (9) ◽  
pp. 3883-3890 ◽  
Author(s):  
Ye Ai ◽  
Mingkan Zhang ◽  
Sang W. Joo ◽  
Marcos A. Cheney ◽  
Shizhi Qian
Keyword(s):  
Electroosmotic Flow ◽  
Ionic Current ◽  
Conical Nanopores ◽  
Current Rectification

Investigation of Ionic Transport Through Track-Etched Conical Nanopores of PET Membrane

NANO ◽  
2018 ◽  
Vol 13 (01) ◽  
pp. 1850011 ◽  
Author(s):  
Mukesh Chander ◽  
Rajesh Kumar ◽  
Sushil Kumar ◽  
Narinder Kumar ◽  
S. K. Chakarvarti
Keyword(s):  
Chemical Etching ◽  
Electrochemical Cell ◽  
Ionic Current ◽  
Electrical Conductance ◽  
Ionic Transport ◽  
Ionic Species ◽  
Voltage Gating ◽  
Conical Nanopores ◽  
Effective Role ◽  
Current Rectification

The control of ionic transportation inside the multi asymmetric conical nanopores in polyethylene terephthalate (PET) membrane was investigated. The conical nanopores were prepared by chemical etching in irradiated PET foil using etchant (9 M NaOH) and stopping solution (1 M NaCl [Formula: see text] 1 M HCOOH). The behavior of ionic current was recorded under stepping voltage [Formula: see text]2[Formula: see text]V to [Formula: see text]2[Formula: see text]V at different molar concentrations of potassium halides (KCl, KBr and KI) under symmetric bathing condition in electrochemical cell. It is found that the presence of multiple ionic species and the occurrence of counterion condensation of charge regulated polyelectrolyte play an effective role in ionic current rectification (ICR). The electrical conductance of conical nanopores may be estimated by measuring the ionic current rectification properties of track-etched nanopores. The charge transport properties vary with molar concentration and pH of electrolyte. Moreover, ICR may be used as a voltage gating phenomena with wide technological applications.

scholarly journals Modulation of Ionic Current Rectification in Ultrashort Conical Nanopores

2020 ◽  
Vol 92 (24) ◽  
pp. 16188-16196
Author(s):  
Long Ma ◽  
Zhongwu Li ◽  
Zhishan Yuan ◽  
Chuanzhen Huang ◽  
Zuzanna S. Siwy ◽  
...  
Keyword(s):  
Ionic Current ◽  
Conical Nanopores ◽  
Current Rectification

scholarly journals Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias

2018 ◽  
Author(s):  
Kazuharu Furutani ◽  
Kunichika Tsumoto ◽  
I-Shan Chen ◽  
Kenichiro Handa ◽  
Yuko Yamakawa ◽  
...  
Keyword(s):  
Action Potential ◽  
Cardiac Arrhythmias ◽  
Action Potential Duration ◽  
Potassium Current ◽  
Low Voltage ◽  
Sodium Current ◽  
Ionic Current ◽  
Delayed Rectifier ◽  
Early Afterdepolarizations ◽  
Herg Channels

AbstractFatal cardiac arrhythmias are caused by some, but not all, drugs that inhibit the cardiac rapid delayed-rectifier current (IKr) by blocking hERG channels. Here, we propose a novel mechanism that could make certain hERG blockers less proarrhythmic. Several drugs that block hERG channels, yet have favorable cardiac safety profiles, also evoke another effect; they increase the current amplitude upon low-voltage depolarization (facilitation). Voltage-clamp recordings of hERG block and facilitation by nifekalant, a Class III antiarrhythmic agent, constrained a model of human cardiac IKr. In human ventricular action potential simulations, nifekalant showed its therapeutic ability to suppress ectopic excitations, with or without facilitation. Without facilitation, excessive IKr block evoked early afterdepolarizations, which cause lethal arrhythmias. Facilitation prevented early afterdepolarizations at the same degree of block by increasing IKr during repolarization phase of action potentials. Thus, facilitation is proposed to reduce the arrhythmogenic risk of hERG blockers.AbbreviationsAP: action potential; APD: action potential duration; APD90: action potential duration measured at 90% repolarization; EAD: early afterdepolarization; hERG: human ether-ago-go-related gene; ICaL: L-type Ca2+ channel current; Inet: net ionic current; IK1: inward-rectifier potassium current; IKr: rapid component of the delayed-rectifier potassium current; INa: sodium current; ORd: O’Hara-Rudy dynamic

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