Enhanced Activation of Atrial Natriuretic Peptide (ANP) and Natriuretic Peptide Receptor-A (NPRA) in Chronic Cigarette Smoke-Induced Lung Inflammation in Experimental Rats

2021 ◽  
Author(s):  
Aadhil Ashwaq Babu ◽  
Elangovan Vellaichamy
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Cigarette Smoke ◽  
Natriuretic Peptide ◽  
Lung Inflammation ◽  
Natriuretic Peptide Receptor ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A ◽  
Atrial Natriuretic

Expression of Mrna for Atrial Natriuretic Peptide Receptor-A in Human Liver: Detection Using RT-PCR

1995 ◽  
Vol 27 (1-2) ◽  
pp. 231-239 ◽  
Author(s):  
Komanduri Pardhasaradhi ◽  
R. Krishnan Kutty ◽  
Roger Bertolotti ◽  
Gopal Krishna
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Human Liver ◽  
Natriuretic Peptide Receptor ◽  
Rt Pcr ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A ◽  
Atrial Natriuretic Peptide Receptor ◽  
Atrial Natriuretic

Suppression of atrial natriuretic peptide/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts

2013 ◽  
Vol 378 (1-2) ◽  
pp. 217-228 ◽  
Author(s):  
Arumugam Parthasarathy ◽  
Venkatachalam Gopi ◽  
Subramanian Umadevi ◽  
Anoop Simna ◽  
Mohammed Jainuddin Yousuf Sheik ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Collagen Synthesis ◽  
Cardiac Fibroblasts ◽  
Natriuretic Peptide Receptor ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A ◽  
Atrial Natriuretic

Dynamics of internalization and sequestration of guanylyl cyclase/atrial natriuretic peptide receptor-A

2001 ◽  
Vol 79 (8) ◽  
pp. 631-639 ◽  
Author(s):  
Kailash N Pandey
Keyword(s):  
Plasma Membrane ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Guanylyl Cyclase ◽  
Culture Media ◽  
Natriuretic Peptide Receptor ◽  
Peptide Receptor ◽  
Receptor Complexes ◽  
Natriuretic Peptide Receptor A ◽  
Atrial Natriuretic

The guanylyl cyclase/natriuretic peptide receptor-A (NPRA), also referred to as GC-A, is a single polypeptide molecule. In its mature form, NPRA resides in the plasma membrane and consists of an extracellular ligand-binding domain, a single transmembrane-spanning region, and intracellular cytoplasmic domain that contains a protein kinase-like homology domain (KHD) and a guanylyl cyclase (GC) catalytic active site. The binding of atrial natriuretic peptide (ANP) to NPRA occurs at the plasma membrane; the receptor is synthesized on the polyribosomes of the endoplasmic reticulum, and is presumably degraded within the lysosomes. It is apparent that NPRA is a dynamic cellular macromolecule that traverses through different compartments of the cell through its lifetime. This review describes the experiments addressing the interaction of ANP with the NPRA, the receptor-mediated internalization and stoichiometric distribution of ANP-NPRA complexes from cell surface to cell interior, and its release into culture media. It is hypothesized that after internalization, the ligand-receptor complexes dissociate inside the cell and a population of NPRA recycles back to plasma membrane. Subsequently, some of the dissociated ligand molecules escape the lysosomal degradative pathway and are released intact into culture media, which reenter the cell by retroendocytotic mechanisms. By utilizing the pharmacologic and physiologic perturbants, the emphasis has been placed on the cellular regulation and processing of ligand-receptor complexes in intact cells. I conclude the discussion by examining the data available on the utilization of deletion mutations of NPRA cDNA, which has afforded experimental insights into the mechanisms the cell utilizes in modulating the expression and functioning of NPRA.Key words: atrial natriuretic peptide receptor-A, guanylyl cyclase receptors, ANP-binding, internalization and recycling of receptor, lysosomal hydrolysis.

Atrial natriuretic peptide-dependent photolabeling of a regulatory ATP-binding site on the natriuretic peptide receptor-A

FEBS Journal ◽  
2005 ◽  
Vol 272 (21) ◽  
pp. 5572-5583 ◽  
Author(s):  
Simon Joubert ◽  
Christian Jossart ◽  
Normand McNicoll ◽  
Andre De Lean
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Binding Site ◽  
Natriuretic Peptide ◽  
Atp Binding ◽  
Natriuretic Peptide Receptor ◽  
Atp Binding Site ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A ◽  
Atrial Natriuretic
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