Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis

2017 ◽  
Vol 430 (1-2) ◽  
pp. 115-125 ◽  
Author(s):  
Naveen Kumar ◽  
Sonal Gupta ◽  
Surbhi Dabral ◽  
Shailja Singh ◽  
Seema Sehrawat
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration ◽  
Exchange Protein

Abstract 5200: Role of MLK3 in breast cancer cell migration and metastasis

2010 ◽  
Author(s):  
Gautam Sondarva ◽  
Suneet Mehrotra ◽  
Rajakishore Mishra ◽  
Velusamy Rangasamy ◽  
Jawed Fareed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration

scholarly journals Interleukin-1βAffects MDAMB231 Breast Cancer Cell Migration under Hypoxia: Role of HIF-1αand NFκB Transcription Factors

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Irene Filippi ◽  
Fabio Carraro ◽  
Antonella Naldini
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Progression ◽  
Hypoxia Inducible Factor ◽  
Tumor Hypoxia ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration

Inflammation and tumor hypoxia are intimately linked and breast cancer provides a typical example of an inflammation-linked malignant disease. Indeed, breast cancer progression is actively supported by inflammatory components, including IL-1β, and by the hypoxia-inducible factor- (HIF-) 1α. In spite of many attempts where the role of either IL-1βor HIF-1αwas evaluated, detailed mechanisms for their effects on breast cancer cell migration under hypoxia are still unclear. We here report that IL-1βincreased MDAMB231 cell migration under hypoxic conditions along with HIF-1αaccumulation and upregulation of CXCR1, which is transcriptionally regulated by HIF-1α, as well as an increased expression of CXCL8 and NFκB. In addition, IL-1β-induced cell migration in hypoxia was not affected when HIF-1αwas inhibited by either siRNA or Topotecan, well known for its inhibitory effect on HIF-1α. Of interest, HIF-1αinhibition did not reduce NFκB and CXCL8 expression and the reduction of IL-1β-induced cell migration under hypoxia was achieved only by pharmacological inhibition of NFκB. Our findings indicate that inhibition of HIF-1αdoes not prevent the migratory program activated by IL-1βin hypoxic MDAMB231 cells. They also suggest a potential compensatory role of NFκB/CXCL8 pathway in IL-1β-induced MDAMB231 cell migration in a hypoxic microenvironment.

scholarly journals Role of TOPK in lipopolysaccharide-induced breast cancer cell migration and invasion

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 40190-40203 ◽  
Author(s):  
Min-Ah Seol ◽  
Jung-Hwan Park ◽  
Ji Heun Jeong ◽  
Jungmook Lyu ◽  
Seung Yun Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Breast Cancer Cell Migration
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