Protective effects of Anthocleista djalonensis A. Chev root extracts against induced testicular inflammation and impaired spermatogenesis in adult rats

2019 ◽  
Vol 46 (6) ◽  
pp. 5983-5994 ◽  
Author(s):  
Chioma Y. Ezirim ◽  
Sunny O. Abarikwu ◽  
Augustine A. Uwakwe ◽  
Chidimma J. Mgbudom-Okah
Keyword(s):  
Protective Effects ◽  
Adult Rats ◽  
Root Extracts ◽  
Testicular Inflammation

PROTECTIVE EFFECTS OF VITAMIN C AGAINST CISPLATIN-INDUCED NEPHROTOXICITY AND LIPID PEROXIDATION IN ADULT RATS: A DOSE-DEPENDENT STUDY

2000 ◽  
Vol 41 (4) ◽  
pp. 405-411 ◽  
Author(s):  
LUSÂNIA M. GREGGI ANTUNES ◽  
JOANA D'ARC C. DARIN ◽  
MARIA DE LOURDES P. BIANCHI
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Protective Effects ◽  
Adult Rats ◽  
Dose Dependent

scholarly journals Protective effects of dietary fibre against manganese-induced neurobehavioral aberrations in rats

2012 ◽  
Vol 63 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Xiu-Quan Shi ◽  
Wei Yan ◽  
Ke-Yue Wang ◽  
Qi-Yuan Fan ◽  
Yan Zou
Keyword(s):  
Cerebral Cortex ◽  
Animal Feed ◽  
Oral Exposure ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Neurobehavioral Performance ◽  
Sprague Dawley Rats ◽  
Applied Dose ◽  
Mn Concentrations

We tested the hypothesis that dietary fi bre (DF) has protective effects against manganese (Mn)-induced neurotoxicity. Forty-eight one-month old Sprague-Dawley rats were randomly divided into six groups: control, 16 % DF, Mn (50 mg kg-1 body weight), Mn+ 4 % DF, Mn+ 8 % DF, and Mn+ 16 % DF. After oral administration of Mn (as MnCl2) by intragastric tube during one month, we determined Mn concentrations in the blood, liver, cerebral cortex, and stool and tested neurobehavioral functions. Administration of Mn was associated with increased Mn concentration in the blood, liver, and cerebral cortex and increased Mn excretion in the stool. Aberrations in neurobehavioral performance included increases in escape latency and number of errors and decrease in step-down latency. Irrespective of the applied dose, the addition of DF in forage decreased tissue Mn concentrations and increased Mn excretion rate in the stool by 20 % to 35 %. All neurobehavioral aberrations were also improved. Our fi ndings show that oral exposure to Mn may cause neurobehavioral abnormalities in adult rats that could be effi ciently alleviated by concomitant supplementation of DF in animal feed.

Protective effects of pomegranate peel against hematotoxicity, chromosomal aberrations, and genotoxicity induced by barium chloride in adult rats

2016 ◽  
Vol 54 (6) ◽  
pp. 964-974 ◽  
Author(s):  
Awatef Elwej ◽  
Ghada Ben Salah ◽  
Choumous Kallel ◽  
Faiza Fakhfakh ◽  
Najiba Zeghal ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Barium Chloride ◽  
Protective Effects ◽  
Pomegranate Peel ◽  
Adult Rats

Protective effects of selenium on methimazole nephrotoxicity in adult rats and their offspring

2011 ◽  
Vol 63 (6) ◽  
pp. 553-561 ◽  
Author(s):  
Ibtissem Ben Amara ◽  
Afef Troudi ◽  
Elmouldi Garoui ◽  
Ahmed Hakim ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Protective Effects ◽  
Adult Rats

Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats

Andrologia ◽  
2018 ◽  
Vol 50 (7) ◽  
pp. e13047 ◽  
Author(s):  
M. Shokoohi ◽  
H. Shoorei ◽  
M. Soltani ◽  
S.-H. Abtahi-Eivari ◽  
R. Salimnejad ◽  
...  
Keyword(s):  
Protective Effects ◽  
Adult Rats ◽  
Hydroalcoholic Extract ◽  
Testicular Injury

scholarly journals Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Zhi Wang ◽  
Ping Li ◽  
Chenjing Wang ◽  
Qixiao Jiang ◽  
Lei Zhang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Protective Effects ◽  
High Fat ◽  
Arctium Lappa ◽  
Root Extracts

scholarly journals Protective effects of Artemisia campestris upon fenthion-induced nephrotoxicity in adult rats and their progeny

2013 ◽  
Vol 32 (04) ◽  
pp. 577-588 ◽  
Author(s):  
Mediha Sefi ◽  
Afef Troudi ◽  
Fatma Ben Hamida ◽  
Nejla Soudani ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Protective Effects ◽  
Adult Rats ◽  
Artemisia Campestris

scholarly journals Protective Effects of Edaravone in Adult Rats with Surgery and Lipopolysaccharide Administration-Induced Cognitive Function Impairment

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153708 ◽  
Author(s):  
Peiqi Wang ◽  
Jiangbei Cao ◽  
Na Liu ◽  
Li Ma ◽  
Xueyue Zhou ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Protective Effects ◽  
Adult Rats ◽  
Function Impairment

scholarly journals The Effects of IGF-1 Treatment after Hypoxic-Ischemic Brain Injury in Adult Rats

1993 ◽  
Vol 13 (4) ◽  
pp. 609-616 ◽  
Author(s):  
Jian Guan ◽  
Chris Williams ◽  
Mark Gunning ◽  
Carina Mallard ◽  
Peter Gluckman
Keyword(s):  
Neuronal Loss ◽  
Ischemic Injury ◽  
Insulin Receptors ◽  
Intraventricular Injection ◽  
Dependent Manner ◽  
Protective Effects ◽  
Adult Rats ◽  
Cortical Temperature ◽  
The Right ◽  
Hypoxic Ischemic Injury

Intraventricular injection of insulin-like growth factor 1 (IGF-1) 2 h after hypoxic–ischemic injury reduces neuronal loss. To clarify the mode of action, we compared histological outcome between treatment groups in the following three studies: 0, 0.5, 5, and 50 μg IGF-1 given 2 h after injury; 0 and 20 μg IGF-1 given 1 h before; and 20 μg IGF-1 and insulin or vehicle alone given 2 h after. Unilateral hypoxic-ischemic injury was induced in adult rats by ligation of the right carotid and exposure to 6% O2 for 10 min. Histological outcome was evaluated in the cortex, striatum, and hippocampus 5 days later. Five to 50 μg IGF-1 reduced the incidence of infarction and neuronal loss in a dose-dependent manner in all regions (p < 0.05), and 50 μg reduced the infarction rate from 87 to 26% (p < 0.01). Pretreatment did not alter outcome. IGF-1 improved outcome compared with equimolar doses of insulin (p < 0.05) and did not affect systemic glucose concentrations or cortical temperature. The results indicate that the neuronal protective effects of IGF-1 are specific and are not mediated via insulin receptors, hypothermia, or hypoglycemic mechanisms. Centrally administered IGF-1 appears to provide worthwhile trophic support to cells within most cerebral structures after transient hypoxic-ischemic injury.

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