SMAD2, SMAD3 and TGF-β GENE expressions in women suffering from urge urinary incontinence and pelvic organ prolapse

Author(s):  
Melike Nur Akin ◽  
Ahmet Akin Sivaslioglu ◽  
Tuba Edgunlu ◽  
Burcu Kasap ◽  
Sevim Karakas Celik
2019 ◽  
Vol 72 (7-8) ◽  
pp. 197-201
Author(s):  
Ljiljana Mladenovic-Segedi

Introduction. Pelvic organ prolapse is commonly associated with symptomatic stress urinary incontinence, in up to 50% of patients. The aim of our research was to examine the quality of life of women with urinary incontinence and pelvic organ prolapse after conventional surgical treatment. Material and Methods. The research included 50 patients with stress urinary incontinence and pelvic organ prolapse that underwent vaginal hysterectomy with anterior and posterior colporrhaphy. The pelvic organ prolapse-quantification system was used to determine the degree of genital prolapse. All patients completed a questionnaire to determine the ?stress and urge? score preoperatively, as well as the Urinary Distress Inventory-6 and Urinary Impact Questionnaire-7 during the follow-up examination, a year after the surgery. Results. One year after surgery, 20 patients (40%) presented with a recurrence of cystocele. The average value of the Urinary Distress Inventory-6 questionnaire a year after surgery was 29.0 ? 10.8, while the average value of the Urinary Impact Questionnaire-7 questionnaire was 3.7 ? 16.3. After the surgery, 6 patients (12%) had persistent stress urinary incontinence and 4 patients (8%) had urge urinary incontinence. Among patients with persistent stress urinary incontinence, two patients reported pronounced symptoms of stress urinary incontinence and reoperation was performed. Conclusion. The classical surgical treatment of pelvic organ prolapse with anterior and posterior colporrhaphy leads to improvement in the quality of life of patients with pelvic organ prolapse and stress urinary incontinence. If the symptoms of stress urinary incontinence persist after classical surgical treatment, other anti-incontinence surgical modalities should be considered.


2021 ◽  
Vol 81 (02) ◽  
pp. 183-190
Author(s):  
Gert Naumann

AbstractThe current treatment for urinary incontinence and pelvic organ prolapse includes a wide range of innovative options for conservative and surgical therapies. Initial treatment for pelvic floor dysfunction consists of individualized topical estrogen therapy and professional training in passive and active pelvic floor exercises with biofeedback, vibration plates, and a number of vaginal devices. The method of choice for the surgical repair of stress urinary incontinence consists of placement of a suburethral sling. A number of different methods are available for the surgical treatment of pelvic organ prolapse using either a vaginal or an abdominal/endoscopic approach and autologous tissue or alloplastic materials for reconstruction. This makes it possible to achieve optimal reconstruction both in younger women, many of them affected by postpartum trauma, and in older women later in their lives. Treatment includes assessing the patientʼs state of health and anesthetic risk profile. It is important to determine a realistically achievable patient preference after explaining the individualized concept and presenting the alternative surgical options.


2007 ◽  
Vol 197 (6) ◽  
pp. 622.e1-622.e7 ◽  
Author(s):  
Rachel N. Pauls ◽  
W. Andre Silva ◽  
Christopher M. Rooney ◽  
Sam Siddighi ◽  
Steven D. Kleeman ◽  
...  

2013 ◽  
Vol 7 (9-10) ◽  
pp. 199 ◽  
Author(s):  
Rebecca G. Rogers

Pelvic floor disorders (PFDs) can impact sexual function. This summary provides an overview of the impact of stress urinary incontinence and pelvic organ prolapse and their treatments on sexual function. In general, interventions that successfully address PFDs will generally improve sexual function as well. However, there are patients whose sexual function will remain unchanged despite treatment, and a small but significant minority who will report worsened sexual function following treatment for their pelvic floor dysfunction.


1997 ◽  
Vol 89 (4) ◽  
pp. 501-506 ◽  
Author(s):  
A OLSEN ◽  
V SMITH ◽  
J BERGSTROM ◽  
J COLLING ◽  
A CLARK

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