Sporotrichosis After Tattooing Caused by Sporothrix brasiliensis

2022 ◽  
Author(s):  
Vivian Fichman ◽  
Dayvison Francis Saraiva Freitas ◽  
Priscila Marques de Macedo ◽  
Antonio Carlos Francesconi do Valle ◽  
Fernando Almeida-Silva ◽  
...  
Keyword(s):  
Sporothrix Brasiliensis

Synthesis and Antifungal Activity of Coumarins Derivatives Against Sporothrix spp.

2018 ◽  
Vol 18 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Luana da S.M. Forezi ◽  
Luana Pereira Borba-Santos ◽  
Mariana F.C. Cardoso ◽  
Vitor F. Ferreira ◽  
Sonia Rozental ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Sporothrix Schenckii ◽  
Public Health Problem ◽  
Domestic Animals ◽  
Coumarin Derivatives ◽  
Sporothrix Brasiliensis ◽  
Synthetic Routes ◽  
Effective Drugs

Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. The three-components synthetic routes used for the preparation of coumarin derivatives have proved to be quite efficient and compounds 16 and 17 have been prepared in good yields. The inhibitory activity of nineteen synthetic coumarins derivatives 16a-i and 17a-j were evaluated against Sporothrix spp. yeasts and the most potent compounds were 16b and 17i. However, according to concentrations able to inhibit (minimum inhibitory concentrations) and kill (minimum fungicidal concentrations) the cells, 17i was more effective than 16b against Sporothrix spp. Thus, 17i exhibited good antifungal activity against S. brasiliensis and S. schenckii, suggesting that it is an important scaffold for the development of novel antifungal agents.

Human Sporotrichosis Outbreak caused by Sporothrix brasiliensis in a Veterinary Hospital in Southern Brazil

2021 ◽  
pp. 101163
Author(s):  
José Raphael Batista Xavier ◽  
Stefanie Bressan Waller ◽  
Luíza da Gama Osório ◽  
Patrícia Silva Vives ◽  
Ana Paula Neuschrank Albano ◽  
...  
Keyword(s):  
Southern Brazil ◽  
Sporothrix Brasiliensis ◽  
Veterinary Hospital

scholarly journals SÍNDROME OCULOGLANDULAR DE PARINAUD COM CULTURA POSITIVA PARA SPOROTHRIX BRASILIENSIS

2021 ◽  
Vol 25 ◽  
pp. 101444
Author(s):  
Amanda Silva Guimarães ◽  
Hugo Pessotti Aborghetti ◽  
Bruno Oggioni Moura ◽  
Luciana Catelan ◽  
Pedro Gabriel Coffler Zorzal ◽  
...  
Keyword(s):  
Sporothrix Brasiliensis

scholarly journals Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient

2019 ◽  
Vol 23 ◽  
pp. 16-19 ◽  
Author(s):  
Walter A. Eyer-Silva ◽  
Marcelo Costa Velho Mendes de Azevedo ◽  
Guilherme Almeida Rosa da Silva ◽  
Rodrigo Panno Basílio-de-Oliveira ◽  
Luciana Ferreira de Araujo ◽  
...  
Keyword(s):  
Infected Patient ◽  
Septal Perforation ◽  
Sporothrix Brasiliensis ◽  
Nasal Septal Perforation

scholarly journals Synthetic Derivatives against Wild-Type and Non-Wild-Type Sporothrix brasiliensis: In Vitro and In Silico Analyses

2022 ◽  
Vol 15 (1) ◽  
pp. 55
Author(s):  
Lais Cavalcanti dos Santos Velasco de Souza ◽  
Lucas Martins Alcântara ◽  
Pãmella Antunes de Macêdo-Sales ◽  
Nathália Faria Reis ◽  
Débora Sena de Oliveira ◽  
...  
Keyword(s):  
In Silico ◽  
Wide Distribution ◽  
Wild Type ◽  
Sporothrix Brasiliensis ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Therapeutic Alternatives ◽  
Synthetic Derivatives ◽  
Prevalent Species

Recently, the well-known geographically wide distribution of sporotrichosis in Brazil, combined with the difficulties of effective domestic feline treatment, has emphasized the pressing need for new therapeutic alternatives. This work considers a range of synthetic derivatives as potential antifungals against Sporothrix brasiliensis isolated from cats from the hyperendemic Brazilian region. Six S. brasiliensis isolates from the sporotrichotic lesions of itraconazole responsive or non-responsive domestic cats were studied. The minimum inhibitory concentrations (MICs) of three novel hydrazone derivatives and eleven novel quinone derivatives were determined using the broth microdilution method (M38-A2). In silico tests were also used to predict the pharmacological profile and toxicity parameters of these synthetic derivatives. MICs and MFCs ranged from 1 to >128 µg/mL. The ADMET computational analysis failed to detect toxicity while a good pharmacological predictive profile, with parameters similar to itraconazole, was obtained. Three hydrazone derivatives were particularly promising candidates as antifungal agents against itraconazole-resistant S. brasiliensis from the Brazilian hyperendemic region. Since sporotrichosis is a neglected zoonosis currently spreading in Latin America, particularly in Brazil, the present data can contribute to its future control by alternative antifungal drug design against S. brasiliensis, the most virulent and prevalent species of the hyperendemic context.

scholarly journals Corrigendum: Clotrimazole is highly effective in vitro against feline Sporothrix brasiliensis isolates

2018 ◽  
Vol 67 (3) ◽  
pp. 463-463
Author(s):  
Thalita Gagini ◽  
Luana Pereira Borba-Santos ◽  
Anderson Messias Rodrigues ◽  
Zoilo Pires de Camargo ◽  
Sonia Rozental
Keyword(s):  
Sporothrix Brasiliensis ◽  
Highly Effective

scholarly journals Avaliação do uso da resazurina em teste de suscetibilidade in vitro frente a Sporothrix brasiliensis

2019 ◽  
Vol 31 (2) ◽  
pp. 32-37
Author(s):  
Beatriz Mendes Roca ◽  
Vanice Rodrigues Poester ◽  
Antonella Souza Mattei ◽  
Gabriel Baracy Klafke ◽  
Ivy Bastos Ramis ◽  
...  
Keyword(s):  
Sporothrix Brasiliensis

A técnica de microdiluição em caldo, que permite determinar a concentração inibitória mínima (CIM) dos fármacos frente aos microrganismos, é considerada padrão ouro para avaliação do perfil de suscetibilidade fúngica in vitro. Considerando que a leitura dos resultados é realizada pela visualização do crescimento fúngico, e que a utilização de indicadores de crescimento microbiano poderia otimizar essa leitura, o estudo teve como objetivo avaliar o uso da resazurina como indicador do crescimento de Sporotrhix brasiliensis em testes de microdiluição em caldo. Cinco isolados clínicos (nas fases leveduriforme e filamentosa) foram testados frente ao itraconazol (ITC – concentrações de 0,0313 a 16 µg/mL) a partir da técnica de microdiluição em caldo, utilizando a resazurina nas concentrações de 0,01% e 0,002%. A leitura dos resultados foi realizada após 24, 48 e 72 horas de incubação, e a CIM dos poços com resazurina foi considerada como sendo a menor concentração sem modificação na coloração, enquanto que a CIM do controle, foi considerada a menor concentração de fármaco capaz de inibir o crescimento fúngico. Os resultados da mudança da cor da resazurina foram comparados com os resultados sem acréscimo de resazurina. A CIM do ITC na microdiluição clássica frente aos isolados testados variou de 0,0625 a 1 µg/mL, porém, com o uso da resazurina como indicador de crescimento fúngico, independente da concentração testada, a CIM foi ≤0,0625 µg/mL. O estudo evidencia que a resazurina não é eficaz como indicador de crescimento de S. brasiliensis visto que não modificou a coloração do meio de cultivo, mesmo na presença visível de crescimento fúngico, sendo portanto contra indicada para uso em testes de suscetibilidade in vitro frente a este microrganismo.

scholarly journals Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity

2018 ◽  
Vol 5 (5) ◽  
Author(s):  
Rafael Mialski ◽  
João Nóbrega de Oliveira ◽  
Larissa Honorato da Silva ◽  
Adriana Kono ◽  
Rosangela Lameira Pinheiro ◽  
...  
Keyword(s):  
Related Species ◽  
Chronic Meningitis ◽  
Sporothrix Brasiliensis ◽  
Immunosuppressed Patients ◽  
Immunocompetent Adults

Abstract Chronic meningitis caused by Sporothrix sp. is occasionally described in immunosuppressed patients. We report the challenges in diagnosing and managing 2 nonimmunocompromised patients with hydrocephalus and chronic meningitis caused by Sporothrix brasiliensis. This more virulent species appears to contribute more atypical and severe cases than other related species.

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