Comparison of the Effects of Systemic (intramuscular) and Intrastriatal Administration of a Selective D1 Dopamine Receptor Blocker on Motor Behavior and Postural Rearrangement in Dogs

2009 ◽  
Vol 40 (1) ◽  
pp. 37-46
Author(s):  
K. B. Shapovalova ◽  
Yu. V. Kamkina
Keyword(s):  
Dopamine Receptor ◽  
Motor Behavior ◽  
Receptor Blocker ◽  
D1 Dopamine Receptor ◽  
Postural Rearrangement ◽  
Intrastriatal Administration

ADRENERGIC INPUTS TO THE AMYGDALA AND THE CONTROL OF GONADOTROPHIN RELEASE

1979 ◽  
Vol 90 (3) ◽  
pp. 385-393 ◽  
Author(s):  
José Borrell ◽  
Flavio Piva ◽  
Luciano Martini
Keyword(s):  
Brain Stem ◽  
Dopamine Receptor ◽  
Serum Levels ◽  
Female Rats ◽  
Receptor Blocker ◽  
Dopaminergic Drug ◽  
Gonadotrophin Secretion ◽  
Biphasic Effect ◽  
Adrenergic Blocker ◽  
The Brain

ABSTRACT Drugs able to mimic or to antagonize the action of catecholamines have been implanted bilaterally into the basomedial region of the amygdala of adult castrated female rats. The animals were killed at different intervals after the implantation of the different drugs, and serum levels of LH and FSH were measured by radioimmunoassay. The results have shown that the intra-amygdalar implantation of the alpha-adrenergic blocker phenoxybenzamine induces a significant increase of the release both of LH and FSH. The implantation of the beta-adrenergic blocker propranolol brings about a rise of LH only. The dopamine receptor blocker pimozide stimulates the release of LH and exerts a biphasic effect (stimulation followed by inhibition) of FSH secretion. The alpha-receptor stimulant clonidine and the dopaminergic drug 2-Br-alpha-ergocryptine were without significant effects. From these observations it is suggested that the adrenergic signals reaching the basomedial area of the amygdala (possibly from the brain stem) may be involved in the modulation of gonadotrophin secretion.

scholarly journals Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

Cell Research ◽  
2021 ◽  
Author(s):  
Youwen Zhuang ◽  
Brian Krumm ◽  
Huibing Zhang ◽  
X. Edward Zhou ◽  
Yue Wang ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Allosteric Modulation ◽  
D1 Dopamine Receptor

Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands

1989 ◽  
Vol 32 (9) ◽  
pp. 2050-2058 ◽  
Author(s):  
Paul S. Charifson ◽  
J. Phillip Bowen ◽  
Steven D. Wyrick ◽  
Andrew J. Hoffman ◽  
Michael Cory ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Conformational Analysis ◽  
Dopamine Receptor ◽  
Receptor Ligands ◽  
D1 Dopamine Receptor

Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1

2007 ◽  
Vol 72 (5) ◽  
pp. 1157-1170 ◽  
Author(s):  
Michael M. C. Kong ◽  
Ahmed Hasbi ◽  
Michael Mattocks ◽  
Theresa Fan ◽  
Brian F. O'Dowd ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Trafficking ◽  
Caveolin 1 ◽  
D1 Dopamine Receptor

Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors

2017 ◽  
Vol 55 (7) ◽  
pp. 5658-5671 ◽  
Author(s):  
Yunjin Lee ◽  
Hannah Kim ◽  
Ji-Eun Kim ◽  
Jin-Young Park ◽  
Juli Choi ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Dorsal Striatum ◽  
Receptor Activation ◽  
D1 Dopamine Receptor

Cross-talk between an activator of nuclear receptors-mediated transcription and the D1 dopamine receptor signaling pathway

2005 ◽  
Vol 80 (3) ◽  
pp. 379-385 ◽  
Author(s):  
Azriel Schmidt ◽  
Robert Vogel ◽  
Su Jane Rutledge ◽  
Evan E. Opas ◽  
Gideon A. Rodan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Dopamine Receptor ◽  
Nuclear Receptors ◽  
Cross Talk ◽  
Receptor Signaling ◽  
D1 Dopamine Receptor ◽  
Receptor Signaling Pathway
Sign in / Sign up

Export Citation Format

Share Document