Metalloproteinase’s Activity and Oxidative Stress in Mild Cognitive Impairment and Alzheimer’s Disease

2008 ◽  
Vol 34 (2) ◽  
pp. 373-378 ◽  
Author(s):  
Sagrario Martín-Aragón ◽  
Paloma Bermejo-Bescós ◽  
Juana Benedí ◽  
Emanuela Felici ◽  
Pedro Gil ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
And Oxidative Stress

scholarly journals Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer’s Disease Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ioana-Miruna Balmuș ◽  
Stefan-Adrian Strungaru ◽  
Alin Ciobica ◽  
Mircea-Nicusor Nicoara ◽  
Romeo Dobrin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Peroxidation ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Association Studies ◽  
Metal Ion Homeostasis ◽  
Brain Functions ◽  
And Oxidative Stress

Increased interest regarding the biometal mechanisms of action and the pathways in which they have regulatory roles was lately observed. Particularly, it was shown that biometal homeostasis dysregulation may lead to neurodegeneration including Alzheimer’s disease, Parkinson disease, or prion protein disease, since important molecular signaling mechanisms in brain functions implicate both oxidative stress and redox active biometals. Oxidative stress could be a result of a breakdown in metal-ion homeostasis which leads to abnormal metal protein chelation. In our previous work, we reported a strong correlation between Alzheimer’s disease and oxidative stress. Consequently, the aim of the present work was to evaluate some of the biometals’ levels (magnesium, manganese, and iron), the specific activity of some antioxidant enzymes (superoxide dismutase and glutathione peroxidase), and a common lipid peroxidation marker (malondialdehyde concentration), in mild cognitive impairment (n=15) and Alzheimer’s disease (n=15) patients, compared to age-matched healthy subjects (n=15). We found increased lipid peroxidation effects, low antioxidant defense, low magnesium and iron concentrations, and high manganese levels in mild cognitive impairment and Alzheimer’s disease patients, in a gradual manner. These data could be relevant for future association studies regarding the prediction of Alzheimer’s disease development risk or circling through stages by analyzing both active redox metals, oxidative stress markers, and the correlations in between.

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

2013 ◽  
Vol 59 ◽  
pp. 100-110 ◽  
Author(s):  
M. Schrag ◽  
C. Mueller ◽  
M. Zabel ◽  
A. Crofton ◽  
W.M. Kirsch ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Meta Analysis

P3-483: Oxidative Stress Peripheral Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease

2010 ◽  
Vol 6 ◽  
pp. e12-e12
Author(s):  
Tania Marcourakis ◽  
Nathalia B. Quaglio ◽  
Larissa H.L. Torres ◽  
Gisele T. Souza ◽  
Raphael C.T. Garcia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease

2011 ◽  
Vol 26 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Larissa Lobo Torres ◽  
Nathalia Barbosa Quaglio ◽  
Gisele Tavares de Souza ◽  
Raphael Tamborelli Garcia ◽  
Lívia Mendonça Munhoz Dati ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease

2010 ◽  
Vol 469 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Manuela Padurariu ◽  
Alin Ciobica ◽  
Lucian Hritcu ◽  
Bogdan Stoica ◽  
Walther Bild ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oxidative Stress Markers ◽  
Stress Markers

Vascular cognitive impairment and Alzheimer’s disease: role of cerebral hypoperfusion and oxidative stress

2012 ◽  
Vol 385 (10) ◽  
pp. 953-959 ◽  
Author(s):  
Hyun Ah Kim ◽  
Alyson A. Miller ◽  
Grant R. Drummond ◽  
Amanda G. Thrift ◽  
Thiruma V. Arumugam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Vascular Cognitive Impairment ◽  
Cerebral Hypoperfusion ◽  
And Oxidative Stress

scholarly journals Relation of Plasma Selenium and Lipid Peroxidation End Products in Patients With Alzheimer’s Disease

2017 ◽  
pp. 1049-1056 ◽  
Author(s):  
Z. CHMATALOVA ◽  
M. VYHNALEK ◽  
J. LACZO ◽  
J. HORT ◽  
R. POSPISILOVA ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Radical Reaction ◽  
Free Radical Reaction ◽  
Plasma Selenium ◽  
End Products ◽  
The Brain

Increased oxidative stress in the brain during the course of Alzheimer’s disease (AD) leads to an imbalance of antioxidants and formation of free radical reaction end-products which may be detected in blood as fluorescent lipofuscin-like pigments (LFPs). The aim of this study was to evaluate and compare LFPs with plasma selenium concentrations representing an integral part of the antioxidant system. Plasma samples from subjects with AD dementia (ADD; n=11), mild cognitive impairment (MCI; n=17) and controls (n=12), were collected. The concentration of selenium was measured using atomic absorption spectroscopy. LFPs were analyzed by fluorescence spectroscopy and quantified for different fluorescent maxima and then correlated with plasma selenium. Lower levels of selenium were detected in MCI and ADD patients than in controls (P=0.003 and P=0.049, respectively). Additionally, higher fluorescence intensities of LFPs were observed in MCI patients than in controls in four fluorescence maxima and higher fluorescence intensities were also observed in MCI patients than in ADD patients in three fluorescence maxima, respectively. A negative correlation between selenium concentrations and LFPs fluorescence was observed in the three fluorescence maxima. This is the first study focused on correlation of plasma selenium with specific lipofuscin-like products of oxidative stress in plasma of patients with Alzheimer´s disease and mild cognitive impairment.

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