This article highlights the implication of site-specific properties on seismic ground response studies. One-dimensional equivalent linear ground response analysis was carried out using site-specific dynamic properties of locally available soils of Guwahati city, and the results are compared with those obtained using existing strain-dependent dynamic properties. Acceleration time histories from three strong motions were used. It was observed that an input motion having a higher peak bedrock acceleration, utilizing experimentally obtained dynamic soil properties, exhibits 38% and 24% lower peak ground acceleration and peak spectral acceleration, respectively, in comparison to the results obtained using standard VD-SI soil models. The amplification characteristics of the strong motions are observed to be significantly influenced by the degradation of damping ratio beyond 1% shear strain. The results highlight the necessity of conducting GRA of any region considering its regional dynamic soil properties to obtain more realistic outcomes.