Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects

We pump-perfused gastrocnemius-plantaris muscle preparations at constant pressure to study the relationship of muscle blood flow (Q) to muscle oxygen consumption (VO2), venous oxygen tension (PVO2), and venous carbon dioxide tension (PVCO2) during steady-state exercise at different rates. Tests were performed under four experimental conditions produced by altering the perfusate blood-gas status with a membrane lung. The consistency of the relationship of Q to other variables was evaluated by statistical analysis of fitted curves. Not one of the above listed variables had the same relationship with Q in all four of the experimental conditions we tested. However, we did find that a consistent relationship existed among Q, PVO2, and PVCO2 in our data. That relationship is well described by the equation (Q-23).[PVO2 - (0.5.PVCO2) - 3] = 105 (when Q is expressed in ml.100 g-1.min-1 and PVO2 and PVCO2 in mmHg). One interpretation of this result is that both PO2 and PCO2 are important variables in the control of blood flow in skeletal muscle the combined influence of which could account for nearly all of the hyperemia response to steady-state muscle exercise.

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Relationship of pyruvate and lactate during anaerobic metabolism. V: Coronary adequacy

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1961.200.6.1169 ◽

1961 ◽

Vol 200 (6) ◽

pp. 1169-1176 ◽

Cited By ~ 79

Author(s):

William E. Huckabee

Keyword(s):

Blood Flow ◽

Coronary Flow ◽

Cardiac Tissue ◽

Anaerobic Metabolism ◽

Constant Ratio ◽

Blood Concentrations ◽

Arterial Blood ◽

Anesthetized Dogs ◽

Relationship Of ◽

The Relationship

Veno-arterial differences of pyruvate and lactate across the myocardium in chloralose-anesthetized dogs were very variable; in any one animal they changed continually with time despite constant blood flow and arterial blood concentrations. There was a systematic tendency of v-a lactate to vary with v-a pyruvate, as expressed in the calculated "Δ excess lactate," which remained nearly constant (or, if blood flow changed, bore a constant ratio to (a-v)O2). No change in Δ excess lactate from control values occurred in nonhypoxic experiments despite marked changes in v-a differences, arterial blood composition, and coronary flow. Cardiac Δ excess lactate became positive in most animals breathing 10% O2 in N2; output of excess lactate was also observed in all those in which moderate muscular exercise was induced. This anaerobic metabolism, or change in the relationship between pyruvate and lactate exchanges, was interpreted as an indication that O2 delivery response was not adequate to meet cardiac tissue requirements during such mild stresses when judged by the standards of adequacy of the basal state.

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Relation of local skin temperature and local sweating to cutaneous blood flow

Journal of Applied Physiology ◽

10.1152/jappl.1963.18.4.781 ◽

1963 ◽

Vol 18 (4) ◽

pp. 781-785 ◽

Cited By ~ 6

Author(s):

Leo C. Senay ◽

Leon D. Prokop ◽

Leslie Cronau ◽

Alrick B. Hertzman

Keyword(s):

Blood Flow ◽

Skin Temperature ◽

Sweat Gland ◽

Cutaneous Blood Flow ◽

Local Skin ◽

Cutaneous Vasodilatation ◽

Local Skin Temperature ◽

Relationship Of ◽

The Relationship ◽

Cutaneous Blood

The relationship of local skin temperature and the onset of sweating to the local cutaneous blood flow was studied in the forearm and calf. The purpose of the investigation was to appraise the possible relation of sweat gland activity to the cutaneous vasodilatation which has been attributed to bradykinin or to intracranial temperatures. The onset of sweating was not marked by any apparently related increases in the rate of cutaneous blood flow. On the contrary, the onset of sweating was followed often by a stabilization or even a decrease in the level of cutaneous blood flow. The relations of the latter to the local skin temperature were complex, particularly in the forearm. There appeared to be additional unidentified influences, possibly vasomotor, operating on the skin vessels during transitional phases in the relation of skin temperature to blood flow. Submitted on October 15, 1962

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