Quantifying In Vivo Luminal Drug Solubilization -Supersaturation-Precipitation Profiles to Explain the Performance of Lipid Based Formulations

2020 ◽  
Vol 37 (3) ◽  
Author(s):  
Yusuke Tanaka ◽  
Erin Tay ◽  
Tri-Hung Nguyen ◽  
Christopher J. H. Porter
Keyword(s):  
Drug Solubilization ◽  
Quantifying In

Quantifying in vivo dopaminergic D2-receptors Bmax and KdVr with microPET® focus after a single injection of [11C]raclopride

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S649-S649
Author(s):  
Laurent Besret ◽  
Jean-Dominique Gallezot ◽  
Frédéric Dollé ◽  
Philippe Hantraye ◽  
Marie-Claude Grégoire
Keyword(s):  
Single Injection ◽  
D2 Receptors ◽  
Quantifying In

scholarly journals Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics

ADMET & DMPK ◽  
2022 ◽  
Author(s):  
Marilyn N. Martinez ◽  
Mark G. Papich ◽  
Raafat Fahmy
Keyword(s):  
Species Differences ◽  
Oral Dosage ◽  
Oral Drug ◽  
Fluid Composition ◽  
In Vitro Test ◽  
Drug Solubility ◽  
Drug Solubilization ◽  
Species Specific

Many gaps exist in our understanding of species differences in gastrointestinal (GI) fluid composition and the associated impact of food intake and dietary composition on in vivo drug solubilization. This information gap can lead to uncertainties with regard to how best to formulate pharmaceuticals for veterinary use or the in vitro test conditions that will be most predictive of species-specific in vivo oral product performance. To address these challenges, this overview explores species-specific factors that can influence oral drug solubility and the formulation approaches that can be employed to overcome solubility-associated bioavailability difficulties. These discussions are framed around some of the basic principles associated with drug solubilization, reported species differences in GI fluid composition, types of oral dosage forms typically given for the various animal species, and the effect of prandial state in dogs and cats. This basic information is integrated into a question-and-answer section that addresses some of the formulation issues that can arise in the development of veterinary medicinals.

scholarly journals A mathematical method for quantifying in vivo mechanical behaviour of heel pad under dynamic load

2015 ◽  
Vol 54 (2-3) ◽  
pp. 341-350 ◽  
Author(s):  
Roozbeh Naemi ◽  
Panagiotis E. Chatzistergos ◽  
Nachiappan Chockalingam
Keyword(s):  
Mathematical Method ◽  
Mechanical Behaviour ◽  
Dynamic Load ◽  
Heel Pad ◽  
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scholarly journals Quantifying in vivo MR spectra with circles

2006 ◽  
Vol 179 (1) ◽  
pp. 152-163 ◽  
Author(s):  
Refaat E. Gabr ◽  
Ronald Ouwerkerk ◽  
Paul A. Bottomley
Keyword(s):  
Quantifying In

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC

2004 ◽  
Vol 1 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Shao-En Ong ◽  
Gerhard Mittler ◽  
Matthias Mann
Keyword(s):  
Quantifying In

Validation of a New Method for Quantifying In Vivo Murine Tumor Necrosis by Sonography

2004 ◽  
Vol 39 (6) ◽  
pp. 350-356 ◽  
Author(s):  
Val??rie Rouffiac ◽  
C??line Bouquet ◽  
Nathalie Lassau ◽  
Paule Opolon ◽  
Serge Koscielny ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
New Method ◽  
Murine Tumor ◽  
Quantifying In
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