The potential of mass spectrometry imaging in plant metabolomics: a review

2015 ◽  
Vol 15 (2) ◽  
pp. 297-316 ◽  
Author(s):  
Heino M. Heyman ◽  
Ian A. Dubery
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Plant Metabolomics

scholarly journals Sample preparation strategy for the detection of steroid-like compounds using MALDI mass spectrometry imaging: pulmonary distribution of budesonide as a case study

2021 ◽  
Author(s):  
Riccardo Zecchi ◽  
Pietro Franceschi ◽  
Laura Tigli ◽  
Davide Amidani ◽  
Chiara Catozzi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Adult Rabbit ◽  
Chronic Obstructive ◽  
Ionization Mass ◽  
Obstructive Pulmonary Disease ◽  
Imaging Protocol ◽  
Girard’S Reagent

AbstractCorticosteroids as budesonide can be effective in reducing topic inflammation processes in different organs. Therapeutic use of budesonide in respiratory diseases, like asthma, chronic obstructive pulmonary disease, and allergic rhinitis is well known. However, the pulmonary distribution of budesonide is not well understood, mainly due to the difficulties in tracing the molecule in lung samples without the addition of a label. In this paper, we present a matrix-assisted laser desorption/ionization mass spectrometry imaging protocol that can be used to visualize the pulmonary distribution of budesonide administered to a surfactant-depleted adult rabbit. Considering that budesonide is not easily ionized by MALDI, we developed an on-tissue derivatization method with Girard’s reagent P followed by ferulic acid deposition as MALDI matrix. Interestingly, this sample preparation protocol results as a very effective strategy to raise the sensitivity towards not only budesonide but also other corticosteroids, allowing us to track its distribution and quantify the drug inside lung samples. Graphical abstract

scholarly journals Shotgun lipidomics and mass spectrometry imaging unveil diversity and dynamics in Gammarus fossarum lipid composition

iScience ◽  
2021 ◽  
Vol 24 (2) ◽  
pp. 102115
Author(s):  
Tingting Fu ◽  
Oskar Knittelfelder ◽  
Olivier Geffard ◽  
Yohann Clément ◽  
Eric Testet ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lipid Composition ◽  
Mass Spectrometry Imaging ◽  
Shotgun Lipidomics ◽  
Gammarus Fossarum
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