Synthesis of some nitrogen heterocycles and in vitro evaluation of their antimicrobial and antitumor activity

2013 ◽  
Vol 40 (2) ◽  
pp. 537-553 ◽  
Author(s):  
J. A. Hasanen ◽  
I. M. El-Deen ◽  
R. M. El-Desoky ◽  
A. M. Abdalla
Keyword(s):  
Antitumor Activity ◽  
Nitrogen Heterocycles ◽  
In Vitro Evaluation

N-phosphinyl ureas: Synthesis, characterization, X-ray structure, and in vitro evaluation of antitumor activity

2011 ◽  
Vol 23 (1) ◽  
pp. 74-83 ◽  
Author(s):  
Khodayar Gholivand ◽  
Nilufar Dorosti ◽  
Fatemeh Ghaziany ◽  
Manouchehr Mirshahi ◽  
Sina Sarikhani
Keyword(s):  
Antitumor Activity ◽  
In Vitro Evaluation ◽  
X Ray

Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity

2017 ◽  
Vol 456 ◽  
pp. 86-94 ◽  
Author(s):  
Stefanie Perfahl ◽  
Anja Bodtke ◽  
Jitka Pracharova ◽  
Jana Kasparkova ◽  
Viktor Brabec ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
In Vitro Evaluation

Comparison of two kinds of docetaxel-vitamin E prodrugs: In vitro evaluation and in vivo antitumor activity

2016 ◽  
Vol 505 (1-2) ◽  
pp. 352-360 ◽  
Author(s):  
Jing Wang ◽  
Peng Xue ◽  
Jiahua Zhou ◽  
Lin Li ◽  
Lu Xu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Antitumor Activity ◽  
In Vitro Evaluation ◽  
In Vivo Antitumor Activity

scholarly journals Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones as Possible Anticancer Agents

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1162
Author(s):  
Serhii Holota ◽  
Sergiy Komykhov ◽  
Stepan Sysak ◽  
Andrzej Gzella ◽  
Andriy Cherkas ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Cancer Cell Lines ◽  
Hek293 Cells ◽  
In Vitro Evaluation ◽  
Anticancer Properties ◽  
Sar Study

The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-b][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-b][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage synthetic protocols. A mixture of Z/E-isomers was obtained in solution for the synthesized 5-aminomethylidene-thiazolo[3,2-b]-[1,2,4]triazole-6-ones. The compounds have been studied for their antitumor activity in the NCI 60 lines screen. Some compounds present excellent anticancer properties at 10 μM. Derivatives 2h and 2i were the most active against cancer cell lines without causing toxicity to normal somatic (HEK293) cells. A preliminary SAR study had been performed for the synthesized compounds.

ChemInform Abstract: N-Phosphinyl Ureas: Synthesis, Characterization, X-Ray Structure, and in vitro Evaluation of Antitumor Activity.

ChemInform ◽  
2012 ◽  
Vol 43 (21) ◽  
pp. no-no
Author(s):  
Khodayar Gholivand ◽  
Nilufar Dorosti ◽  
Fatemeh Ghaziany ◽  
Manouchehr Mirshahi ◽  
Sina Sarikhani
Keyword(s):  
Antitumor Activity ◽  
In Vitro Evaluation ◽  
X Ray
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