DNA-binding, antioxidant activity and in vitro cytotoxicity induced by ruthenium(II) complexes containing polypyridyl ligands

2010 ◽  
Vol 35 (6) ◽  
pp. 731-736 ◽  
Author(s):  
Cheng-Hui Zeng ◽  
Yun-Jun Liu ◽  
Zheng-Zheng Li ◽  
Zhen-Hua Liang ◽  
Hong-Liang Huang ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Polypyridyl Ligands

DNA Binding Behavior, Sensor Studies, Antimicrobial, Photocleavage and In vitro Cytotoxicity of Synthesized Ru(II) Complexes with Assorted Intercalating Polypyridyl Ligands

2016 ◽  
Vol 26 (3) ◽  
pp. 1101-1113 ◽  
Author(s):  
Rajender Reddy Mallepally ◽  
Venkat Reddy Putta ◽  
Nagamani Chintakuntla ◽  
Ravi Kumar Vuradi ◽  
Laxma Reddy Kotha ◽  
...  
Keyword(s):  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Polypyridyl Ligands ◽  
Binding Behavior

New binuclear Ni(ii) metallates containing ONS chelators: synthesis, characterisation, DNA binding, DNA cleavage, protein binding, antioxidant activity, antimicrobial and in vitro cytotoxicity

2017 ◽  
Vol 41 (7) ◽  
pp. 2543-2560 ◽  
Author(s):  
G. Kalaiarasi ◽  
Ruchi Jain ◽  
H. Puschman ◽  
S. Poorna Chandrika ◽  
K. Preethi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Protein Binding ◽  
Hela Cell ◽  
Antiproliferative Activity ◽  
Dna Cleavage ◽  
In Vitro Cytotoxicity ◽  
Hela Cell Lines ◽  
Mcf 7

Four new binuclear nickel(ii) metallates showed promising antiproliferative activity against MCF-7 and HeLa cell lines and were much less toxic against HaCaT.

scholarly journals Synthesis and in vitro Cytotoxicity Study of Novel 4-Substituted Quinazolines Encompassed with Thiazolidinone and Azetidinone

2020 ◽  
Vol 32 (10) ◽  
pp. 2617-2623
Author(s):  
Akash Jori ◽  
Sheshagiri R. Dixit ◽  
Gurubasavraj V. Pujar
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Dna Binding ◽  
Anticancer Activity ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
In Vitro Cytotoxicity ◽  
Free Radical Scavenging ◽  
Binding Studies

A series of quinazolines encompassed with thiazolidinone and azetidinone have been synthesized and evaluated for their antioxidant, anticancer and DNA binding studies. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectra. Antioxidant activity was carried out using % free radical scavenging by DPPH assay. Compounds 4b, 5b and 5d have shown better antioxidant activity (60, 67 and 66%, respectively) among the tested compounds. Compounds having % free radical scavenging activity more than 55% were evaluated for anticancer activity by MTT assay towards cell lines A-549 (lung carcinoma) and MDA-231 (human breast cancer). Results revealed that the tested compounds exhibited moderate to low anticancer activity. Further, DNA binding activity was studied by absorption titration method for all the synthesized compounds, and compound 5b showed a good binding constant of 70.05 and % hyperchromicity of 82.93%.

In Vitro Cytotoxicity, Apoptosis, DNA-Binding, and Antioxidant Activity Studies of Ruthenium (II) Complexes

2010 ◽  
Vol 29 (5) ◽  
pp. 261-270 ◽  
Author(s):  
Hong-Liang Huang ◽  
Yun-Jun Liu ◽  
Cheng-Hui Zeng ◽  
Li-Xin He ◽  
Fu-Hai Wu
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
In Vitro Cytotoxicity

DNA binding, docking studies, artificial nuclease activity and in vitro cytotoxicity of newly synthesized steroidal 1H–pyrimidines

2014 ◽  
Vol 17 (4) ◽  
pp. 359-369 ◽  
Author(s):  
Shamsuzzaman ◽  
Ayaz Mahmood Dar ◽  
Sartaj Tabassum ◽  
Mehvash Zaki ◽  
Yusuf Khan ◽  
...  
Keyword(s):  
Dna Binding ◽  
Nuclease Activity ◽  
Docking Studies ◽  
In Vitro Cytotoxicity ◽  
Artificial Nuclease
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