Three Schiff base complexes based on diethylenetriamine: synthesis, structure, DNA binding and cleavage, and in vitro cytotoxicity

2019 ◽  
Vol 44 (5) ◽  
pp. 463-474
Author(s):  
Ziwei Fang ◽  
Jun Yan ◽  
Weidong Yu ◽  
Nan Zhang ◽  
Shouchun Zhang
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Schiff Base Complexes ◽  
Dna Binding And Cleavage

Synthesis, characterization, in vitro cytotoxicity activity, and molecular docking studies of mononuclear and binuclear Macroacyclic Schiff base complexes

Polyhedron ◽  
2021 ◽  
pp. 115380
Author(s):  
Hassan Keypour ◽  
Fatemeh Forouzandeh ◽  
Saadat Hajari ◽  
Mahdi Jamshidi ◽  
Seyed Hamed Moazzami Farida ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Docking Studies ◽  
In Vitro Cytotoxicity ◽  
Schiff Base Complexes ◽  
Molecular Docking Studies ◽  
Cytotoxicity Activity

Novel thiazolium ionic liquids-tagged bicyclo-palladium(II) Schiff base complexes; Synthesis, characterization and in vitro cytotoxicity toward ovarian cancer

2022 ◽  
Vol 1249 ◽  
pp. 131594
Author(s):  
Mohammad Y. Alfaifi ◽  
Serag Eldin I. Elbehairi ◽  
Reda F.M. Elshaarawy ◽  
Mohamed A.-E. Zein
Keyword(s):  
Ovarian Cancer ◽  
Schiff Base ◽  
Ionic Liquids ◽  
In Vitro Cytotoxicity ◽  
Schiff Base Complexes

Synthesis, characterization, DNA binding and cleavage properties and anticancer studies of ruthenium(III) Schiff base complexes

2011 ◽  
Vol 37 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Gunasekaran Raja ◽  
Ray J. Butcher ◽  
Chinnasamy Jayabalakrishnan
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Dna Binding And Cleavage

Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base

2010 ◽  
Vol 64 (3) ◽  
Author(s):  
Natarajan Raman ◽  
Ramaraj Jeyamurugan ◽  
Mariyyappan Subbulakshmi ◽  
Raja Boominathan ◽  
Chithu Yuvarajan
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Dna Cleavage ◽  
Double Helix ◽  
Structural Features ◽  
Schiff Base Complexes ◽  
Diffusion Method ◽  
Spectral Techniques ◽  
Antimicrobial Studies

AbstractA novel series of Co(II), Ni(II), Cu(II), Zn(II), and VO(IV) complexes has been synthesized from the Schiff base derived from 4-[(3,4-dimethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one and 1,2-diaminobenzene. Structural features were determined by analytical and spectral techniques. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods and viscosity measurements. Experimental results indicate that the complexes are able to form adducts with DNA and to distort the double helix by changing the base stacking. Lower DNA affinity of the VO(IV) complex is caused by the change of coordination geometry by the vanadyl ion resulting in a somewhat unfavorable configuration for the DNA binding. Oxidative DNA cleavage activities of the complexes were studied with supercoiled (SC) pUC19 DNA using gel electrophoresis; the mechanism studies revealed that the hydroxyl radical is likely to be the reactive species responsible for the cleavage of pUC19 DNA by the synthesized complexes. The in vitro antimicrobial screening effects of the investigated compounds were monitored by the disc diffusion method. The synthesized Schiff base complexes exhibit higher antimicrobial activity than the respective free Schiff base.

DNA binding and cleavage activity of reduced amino-acid Schiff base complexes of cobalt(II), copper(II), and cadmium(II)

2009 ◽  
Vol 34 (5) ◽  
pp. 475-481 ◽  
Author(s):  
Xiao-Fang Ma ◽  
Dong-Dong Li ◽  
Jin-Lei Tian ◽  
Ying-Ying Kou ◽  
Shi-Ping Yan
Keyword(s):  
Schiff Base ◽  
Amino Acid ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Cleavage Activity ◽  
Amino Acid Schiff Base ◽  
Dna Binding And Cleavage

Synthesis, characterization, DNA binding studies and in vitro cytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelating N-donor ligands

2016 ◽  
Vol 69 (16) ◽  
pp. 2422-2436 ◽  
Author(s):  
Radka Křikavová ◽  
Ján Vančo ◽  
Tomáš Šilha ◽  
Jaromír Marek ◽  
Zdeněk Trávníček
Keyword(s):  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Donor Ligands ◽  
Binding Studies ◽  
Dna Binding Studies
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