Gremlin1 and TGF-β1 protect kidney tubular epithelial cells from ischemia–reperfusion injury through different pathways

2021 ◽  
Author(s):  
Xuxia Gao ◽  
Liyuan Han ◽  
Xinbao Yao ◽  
Liping Ma
Keyword(s):  
Epithelial Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tubular Epithelial Cells ◽  
Tgf Β1

BCL-2 PROTECTS TUBULAR EPITHELIAL CELLS FROM ISCHEMIA REPERFUSION INJURY VIA DUAL MECHANISMS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 579
Author(s):  
T Abe ◽  
C Suzuki ◽  
Y Isaka ◽  
M Okumi ◽  
N Ichimaru ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tubular Epithelial Cells

scholarly journals Cell Death Patterns Due to Warm Ischemia or Reperfusion in Renal Tubular Epithelial Cells Originating from Human, Mouse, or the Native Hibernator Hamster

Biology ◽  
2018 ◽  
Vol 7 (4) ◽  
pp. 48 ◽  
Author(s):  
Theodoros Eleftheriadis ◽  
Georgios Pissas ◽  
Georgia Antoniadi ◽  
Vassilios Liakopoulos ◽  
Ioannis Stefanidis
Keyword(s):  
Lipid Peroxidation ◽  
Acute Kidney Injury ◽  
Cell Death ◽  
Epithelial Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Human Cells ◽  
Tubular Epithelial Cells

Ischemia–reperfusion injury contributes to the pathogenesis of many diseases, with acute kidney injury included. Hibernating mammals survive prolonged bouts of deep torpor with a dramatic drop in blood pressure, heart, and breathing rates, interspersed with short periods of arousal and, consequently, ischemia–reperfusion injury. Clarifying the differences under warm anoxia or reoxygenation between human cells and cells from a native hibernator may reveal interventions for rendering human cells resistant to ischemia–reperfusion injury. Human and hamster renal proximal tubular epithelial cells (RPTECs) were cultured under warm anoxia or reoxygenation. Mouse RPTECs were used as a phylogenetic control for hamster cells. Cell death was assessed by both cell imaging and lactate dehydrogenase (LDH) release assay, apoptosis by cleaved caspase-3, autophagy by microtubule-associated protein 1-light chain 3 B II (LC3B-II) to LC3B-I ratio, necroptosis by phosphorylated mixed-lineage kinase domain-like pseudokinase, reactive oxygen species (ROS) fluorometrically, and lipid peroxidation, the end-point of ferroptosis, by malondialdehyde. Human cells died after short periods of warm anoxia or reoxygenation, whereas hamster cells were extremely resistant. In human cells, apoptosis contributed to cell death under both anoxia and reoxygenation. Although under reoxygenation, ROS increased in both human and hamster RPTECs, lipid peroxidation-induced cell death was detected only in human cells. Autophagy was observed only in human cells under both conditions. Necroptosis was not detected in any of the evaluated cells. Clarifying the ways that are responsible for hamster RPTECs escaping from apoptosis and lipid peroxidation-induced cell death may reveal interventions for preventing ischemia–reperfusion-induced acute kidney injury in humans.

scholarly journals Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 24154-24162 ◽  
Author(s):  
Da Xie ◽  
Yong Xu ◽  
Wang Jing ◽  
Zeng Juxiang ◽  
Li Hailun ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Tubular Epithelial Cells ◽  
Renal Ischemia Reperfusion Injury

scholarly journals Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells

2019 ◽  
Vol 95 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Stephanie F. Smith ◽  
Sarah A. Hosgood ◽  
Michael L. Nicholson
Keyword(s):  
Renal Transplantation ◽  
Epithelial Cells ◽  
Reperfusion Injury ◽  
Signaling Pathways ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tubular Epithelial Cells

scholarly journals Osteopontin Expressed in Tubular Epithelial Cells Regulates NK Cell-Mediated Kidney Ischemia Reperfusion Injury

2010 ◽  
Vol 185 (2) ◽  
pp. 967-973 ◽  
Author(s):  
Zhu-Xu Zhang ◽  
Kelvin Shek ◽  
Shuang Wang ◽  
Xuyan Huang ◽  
Arthur Lau ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Reperfusion Injury ◽  
Nk Cell ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tubular Epithelial Cells ◽  
Kidney Ischemia
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