scholarly journals Molecular Imaging Using Light-Absorbing Imaging Agents and a Clinical Optical Breast Imaging System—a Phantom Study

2010 ◽  
Vol 13 (2) ◽  
pp. 232-238 ◽  
Author(s):  
Stephanie M. W. Y. van de Ven ◽  
Niculae Mincu ◽  
Jean Brunette ◽  
Guobin Ma ◽  
Mario Khayat ◽  
...  
Author(s):  
Mithun Kuniyil Ajith Singh ◽  
Maura Dantuma ◽  
Francis Kalloor Joseph ◽  
Srirang Manohar ◽  
Wiendelt Steenbergen

2020 ◽  
Vol 12 (6) ◽  
pp. 469-476
Author(s):  
Elham Norouzzadeh ◽  
Somayyeh Chamaani ◽  
Jochen Moll ◽  
Christian Kexel ◽  
Duy Hai Nguyen ◽  
...  

AbstractEarly detection of breast cancer is required to increase the chances of a successful treatment. However, current breast-imaging systems such as X-Ray mammography, breast ultrasound, and magnetic resonance imaging have technological limitations so that novel solutions are needed to address this major societal problem. The current paper considers ultra-wideband (UWB) microwave radiation in the frequency band from 1 to 9 GHz. Given by the non-ionizing nature of microwaves frequent check-ups are more feasible. In this work, we propose algorithms for qualitative and quantitative microwave breast imaging for a transmission-based UWB system. Based on numerical and experimental data, the performance of the algorithms has been investigated and compared. Finally, microwave images obtained during an initial patient study are discussed relative to corresponding X-ray images.


Author(s):  
Yazan Abdoush ◽  
Angie Fasoula ◽  
Luc Duchesne ◽  
Julio D. Gil Cano ◽  
Brian M. Moloney ◽  
...  

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Yoko Satoh ◽  
Utaroh Motosugi ◽  
Masamichi Imai ◽  
Yoshie Omiya ◽  
Hiroshi Onishi

Abstract Background Using phantoms and clinical studies in prone hanging breast imaging, we assessed the image quality of a commercially available dedicated breast PET (dbPET) at the detector’s edge, where mammary glands near the chest wall are located. These are compared to supine PET/CT breast images of the same clinical subjects. Methods A breast phantom with four spheres (16-, 10-, 7.5-, and 5-mm diameter) was filled with 18F-fluorodeoxyglucose solution (sphere-to-background activity concentration ratio, 8:1). The spheres occupied five different positions from the top edge to the centre of the detector and were scanned for 5 min in each position. Reconstructed images were visually evaluated, and the contrast-to-noise ratio (CNR), contrast recovery coefficient (CRC) for all spheres, and coefficient of variation of the background (CVB) were calculated. Subsequently, clinical images obtained with standard supine PET/CT and prone dbPET were retrospectively analysed. Tumour-to-background ratios (TBRs) between breast cancer near the chest wall (close to the detector’s edge; peripheral group) and at other locations (non-peripheral group) were compared. The TBR of each lesion was compared between dbPET and PET/CT. Results Closer to the detector’s edge, the CNR and CRC of all spheres decreased while the CVB increased in the phantom study. The disadvantages of this placement were visually confirmed. Regarding clinical images, TBR of dbPET was significantly higher than that of PET/CT in both the peripheral (12.38 ± 6.41 vs 6.73 ± 3.5, p = 0.0006) and non-peripheral (12.44 ± 5.94 vs 7.71 ± 7.1, p = 0.0183) groups. There was no significant difference in TBR of dbPET between the peripheral and non-peripheral groups. Conclusion The phantom study revealed poorer image quality at < 2-cm distance from the detector’s edge than at other more central parts. In clinical studies, however, the visibility of breast lesions with dbPET was the same regardless of the lesion position, and it was higher than that in PET/CT. dbPET has a great potential for detecting breast lesions near the chest wall if they are at least 2 cm from the edge of the FOV, even in young women with small breasts.


2021 ◽  
Vol 15 ◽  
pp. 174830262110080
Author(s):  
Changjun Zha* ◽  
Qian Zhang* ◽  
Huimin Duan

Traditional single-pixel imaging systems are aimed mainly at relatively static or slowly changing targets. When there is relative motion between the imaging system and the target, sizable deviations between the measurement values and the real values can occur and result in poor image quality of the reconstructed target. To solve this problem, a novel dynamic compressive imaging system is proposed. In this system, a single-column digital micro-mirror device is used to modulate the target image, and the compressive measurement values are obtained for each column of the image. Based on analysis of the measurement values, a new recovery model of dynamic compressive imaging is given. Differing from traditional reconstruction results, the measurement values of any column of vectors in the target image can be used to reconstruct the vectors of two adjacent columns at the same time. Contingent upon characteristics of the results, a method of image quality enhancement based on an overlapping average algorithm is proposed. Simulation experiments and analysis show that the proposed dynamic compressive imaging can effectively reconstruct the target image; and that when the moving speed of the system changes within a certain range, the system reconstructs a better original image. The system overcomes the impact of dynamically changing speeds, and affords significantly better performance than traditional compressive imaging.


Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 647
Author(s):  
Sameer Alani ◽  
Zahriladha Zakaria ◽  
Tale Saeidi ◽  
Asmala Ahmad ◽  
Muhammad Ali Imran ◽  
...  

Skin cancer is one of the most widespread and fast growing of all kinds of cancer since it affects the human body easily due to exposure to the Sun’s rays. Microwave imaging has shown better outcomes with higher resolution, faster processing time, mobility, and less cutter and artifact effects. A miniaturized elliptical ultra-wideband (UWB) antenna and its semi-spherical array arrangement were used for signal transmission and reception from the defected locations in the breast skin. Several conditions such as various arrays of three, six, and nine antenna elements, smaller tumor, multi-tumors, and skin on a larger breast sample of 30 cm were considered. To assess the ability of the system, a breast shape container with a diameter of 130 mm and height of 60 mm was 3D printed and then filled with fabricated skin and breast fat to perform the experimental investigation. An improved modified time-reversal algorithm (IMTR) was used to recreate 2D images of tumors with the smallest radius of 1.75 mm in any location within the breast skin. The reconstructed images using both simulated and experimental data verified that the system can be a reliable imaging system for skin cancer diagnosis having a high structural similarity index and resolution.


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