Obstructive sleep apnea risk and leukocyte telomere length in African Americans from the MH-GRID study

Background: Obstructive sleep apnea (OSA) is a common disorder in which breathing repeatedly stops during sleep. Leukocyte telomere length (LTL) and OSA are linked with an increased risk of oxidative stress and inflammation. The possible link between LTL and OSA in Asian Indians has not been evaluated. Thus, the present study aims to compare the link between LTL and OSA in Asian Indians.Methods: In this study, 300 subjects (120 obese with OSA, 110 obese without OSA, and 70 non-obese without OSA) were included after overnight polysomnography and a fasting blood sample. Clinical, anthropometry, metabolic markers, insulin, 25-hydroxyvitamin D [25(OH) D], and parathyroid hormones (PTH) levels were investigated. LTL was investigated by a QPCR. Univariate and stepwise multivariate linear regression analyses adjusting for age, gender, BMI, and % body fat were conducted while treating LTL as a dependent variable in relation to AHI and other covariates.Results: Obese subjects with OSA had significantly decreased 25(OH)D and increased PTH levels. The mean telomere length (T/S) ratio was significantly shorter in patients with OSA. The adjusted correlation analysis showed that shortening of telomere length correlated with increasing age, apnea-hypopnea index (AHI), oxygen desaturation index, and RDI. Univariate analysis showed that LTL revealed a trend toward a negative correlation with a mean age (β + SE, −0.015 + 0.0006; p = 0.01) and positive correlation with AHI [β +slandered error (SE), 0.042 + 0.017; p = 0.008]. In the multiple regression analysis, LTL was positively associated with AHI (β + SE, 0.281 + 0.04; p = 0.001) after adjusting for age, sex, BMI, and % body fat. Even when adjusted for confounding factors, 25(OH)D, and PTH levels, LTL still was related to AHI (β + SE, 0.446 + 0.02; p = 0.05).Conclusion: Our study indicates the presence of an association between LTL and OSA and a significant impact of OSA severity and telomeres shortening in Asian Indians.

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Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis

SLEEP ◽

10.1093/sleep/zsz089 ◽

2019 ◽

Vol 42 (7) ◽

Cited By ~ 3

Author(s):

Judith E Carroll ◽

Michael R Irwin ◽

Teresa E Seeman ◽

Ana V Diez-Roux ◽

Aric A Prather ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Telomere Length ◽

Sleep Onset ◽

Biological Aging ◽

Apnea Hypopnea Index ◽

Leukocyte Telomere Length ◽

Ethnic Study ◽

Age Related ◽

Obstructive Sleep

AbstractStudy ObjectivesSleep disturbances and sleep apnea are associated with increased vulnerability to age-related disease, altering molecular pathways affecting biological aging. Telomere length captures one component of biological aging. We evaluated whether objectively assessed sleep and sleep apnea relate to leukocyte telomere length (LTL) in the Multi-Ethnic Study of Atherosclerosis (MESA).MethodsMen and women aged 44–84 years (n = 672) from the MESA Stress and MESA Sleep studies underwent polysomnography and 7 day actigraphy (at Exam 5) and assessment of LTL (at baseline [Exam 1] and about 10 years later [Exam 5]).ResultsGeneral linear models adjusting for age, sex, race/ethnicity, BMI, physical activity, and smoking found that severe obstructive sleep apnea (OSA; apnea–hypopnea index > 30) was cross-sectionally associated with shorter LTL (p = 0.007). Modest associations of shorter LTL with less rapid eye movement sleep, more stage 1 sleep, wake after sleep onset >30 min, and long sleep duration were found, but these effects were diminished after adjusting for lifestyle and OSA. Exploratory analyses found that higher arousal index at Exam 5 was associated with greater LTL decline over the prior 10 years (p = 0.004).ConclusionsOSA was associated with shorter LTL. Individuals with high-arousal frequency had greater leukocyte telomere attrition over the prior decade. These findings suggest that sleep apnea and sleep fragmentation are associated with accelerated biological aging.

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Klotho genetic variants mediate the association between obstructive sleep apnea and short telomere length

Sleep Medicine ◽

10.1016/j.sleep.2021.01.015 ◽

2021 ◽

Author(s):

Priscila Farias Tempaku ◽

Vânia D’Almeida ◽

Sylvia Maria Affonso da Silva ◽

Monica Levy Andersen ◽

Sintia Iole Belangero ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Telomere Length ◽

Genetic Variants ◽

Short Telomere ◽

Obstructive Sleep

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The effect of the severity of obstructive sleep apnea syndrome on telomere length

Oncotarget ◽

10.18632/oncotarget.12293 ◽

2016 ◽

Vol 7 (43) ◽

pp. 69216-69224 ◽

Cited By ~ 10

Author(s):

Priscila Farias Tempaku ◽

Diego Robles Mazzotti ◽

Camila Hirotsu ◽

Monica Levy Andersen ◽

Gabriela Xavier ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Telomere Length ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Obstructive Sleep ◽

Apnea Syndrome

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Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients

Cells ◽

10.3390/cells8050381 ◽

2019 ◽

Vol 8 (5) ◽

pp. 381 ◽

Cited By ~ 1

Author(s):

Katarzyna Polonis ◽

Sreeja Sompalli ◽

Christiane Becari ◽

Jiang Xie ◽

Naima Covassin ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Telomere Length ◽

Incidence Rates ◽

Major Adverse Cardiac Events ◽

Entire Group ◽

Cardiac Events ◽

Obstructive Sleep ◽

Adverse Cardiac Events

Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied 210 individuals undergoing sleep-related studies between 2000 and 2007. Baseline characteristics and follow-up data (available in 164 subjects) were obtained from clinic records. Incidence rates were calculated for the entire group and by OSA status. Hazard ratios were calculated to estimate effects of OSA and TL on risk of MACE and cancer. In total, 32 individuals (20%) developed MACE and/or cancer during 12.7-year follow-up. The OSA group had a higher likelihood of cancer (16.0 vs. 4.9 events per 1000 person-years, P = 0.044) but no clear evidence of an elevated incidence of MACE (10.8 vs. 4.8 events per 1000 person-years, P = 0.293) compared to the non-OSA group. There was no association between TL and MACE- (HR = 1.01, 95% CI 0.78–1.28), or cancer-risk (HR = 1.18, 95% CI 0.96–1.43). Our study warrants further investigation of any modulating effect of OSA on TL and the risk of MACE and cancer.

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