Association between serum folate levels and blood concentrations of cadmium and lead in US adults

2021 ◽  
Author(s):  
Zuxiang Wu ◽  
Huan Hu ◽  
Chenxi Wang ◽  
Ji Wu ◽  
Yurong Xiong ◽  
...  
Keyword(s):  
Serum Folate ◽  
Blood Concentrations ◽  
Cadmium And Lead

Correlation between urine and blood concentrations, and dietary intake of cadmium and lead among women in the general population of Japan

2000 ◽  
Vol 73 (3) ◽  
pp. 163-170 ◽  
Author(s):  
S. Shimbo ◽  
Z. -W. Zhang ◽  
C. -S. Moon ◽  
T. Watanabe ◽  
H. Nakatsuka ◽  
...  
Keyword(s):  
General Population ◽  
Dietary Intake ◽  
Blood Concentrations ◽  
Cadmium And Lead

Variation in Blood Concentrations of Cadmium and Lead in the Elderly

1999 ◽  
Vol 80 (3) ◽  
pp. 222-230 ◽  
Author(s):  
Maria Bæcklund ◽  
Nancy L. Pedersen ◽  
Lars Björkman ◽  
Marie Vahter
Keyword(s):  
The Elderly ◽  
Blood Concentrations ◽  
Cadmium And Lead

scholarly journals Increased urinary cobalt and whole blood concentrations of cadmium and lead in women with uterine leiomyomata: Findings from the ENDO Study

2014 ◽  
Vol 49 ◽  
pp. 27-32 ◽  
Author(s):  
Erica B. Johnstone ◽  
Germaine M. Buck Louis ◽  
Patrick J. Parsons ◽  
Amy J. Steuerwald ◽  
Christopher D. Palmer ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Concentrations ◽  
Uterine Leiomyomata ◽  
Cadmium And Lead

ENVIRONMENTAL AND GENETIC FACTORS INFLUENCING BLOOD CONCENTRATIONS OF CADMIUM AND LEAD

Epidemiology ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. S154
Author(s):  
M Backlund ◽  
L Bjorkman ◽  
N L Pedersen ◽  
M Vahter
Keyword(s):  
Genetic Factors ◽  
Blood Concentrations ◽  
Factors Influencing ◽  
Cadmium And Lead

scholarly journals Lifestyle-Related Exposure to Cadmium and Lead is Associated with Diabetic Kidney Disease

2020 ◽  
Vol 9 (8) ◽  
pp. 2432 ◽  
Author(s):  
Ilse J. M. Hagedoorn ◽  
Christina M. Gant ◽  
Sanne v. Huizen ◽  
Ronald G. H. J. Maatman ◽  
Gerjan Navis ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Creatinine Clearance ◽  
Diabetic Kidney Disease ◽  
Lead Concentration ◽  
Cadmium Concentration ◽  
Blood Concentrations ◽  
Diabetic Kidney ◽  
Increased Risk ◽  
Blood Cadmium ◽  
Cadmium And Lead

Background: Environmental factors contributing to diabetic kidney disease are incompletely understood. We investigated whether blood cadmium and lead concentrations were associated with the prevalence of diabetic kidney disease, and to what extent lifestyle-related exposures (diet and smoking) contribute to blood cadmium and lead concentrations. Material and methods: In a cross-sectional analysis in 231 patients with type 2 diabetes included in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1), blood cadmium and lead concentrations were determined using inductively coupled plasma mass spectrometry. The associations between diet (derived from food frequency questionnaire), smoking and cadmium and lead were determined using multivariate linear regression. The associations between cadmium and lead and diabetic kidney disease (albumin excretion >30 mg/24 h and/or creatinine clearance <60 mL/min/1.73 m2) were determined using multivariate logistic regression. Results: Median blood concentrations were 2.94 nmol/L (interquartile range (IQR): 1.78–4.98 nmol/L) for cadmium and 0.07 µmol/L (IQR: 0.04–0.09 µmol/L) for lead, i.e., below acute toxicity values. Every doubling of lead concentration was associated with a 1.75 (95% confidence interval (CI): 1.11–2.74) times higher risk for albuminuria. In addition, both cadmium (odds ratio (OR) 1.50 95% CI: 1.02–2.21) and lead (OR 1.83 95% CI: 1.07–3.15) were associated with an increased risk for reduced creatinine clearance. Both passive smoking and active smoking were positively associated with cadmium concentration. Alcohol intake was positively associated with lead concentration. No positive associations were found between dietary intake and cadmium or lead. Conclusions: The association between cadmium and lead and the prevalence of diabetic kidney disease suggests cadmium and lead might contribute to the development of diabetic kidney disease. Exposure to cadmium and lead could be a so far underappreciated nephrotoxic mechanism of smoking and alcohol consumption.

scholarly journals The association of cadmium and lead exposures with red cell distribution width

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245173
Author(s):  
Junenette L. Peters ◽  
Melissa J. Perry ◽  
Eileen McNeely ◽  
Robert O. Wright ◽  
Wendy Heiger-Bernays ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cadmium Concentration ◽  
Population Sample ◽  
Cell Distribution ◽  
Blood Concentrations ◽  
Distribution Width ◽  
Incidence And Mortality ◽  
Blood Cadmium ◽  
Cadmium And Lead

Elevated red blood cell distribution width (RDW), traditionally an indicator of anemia, has now been recognized as a risk marker for cardiovascular disease incidence and mortality. Experimental and acute exposure studies suggest that cadmium and lead individually affect red blood cell production; however, associations between environmental exposures and RDW have not been explored. We evaluated relationships of environmental cadmium and lead exposures to RDW. We used data from 24,607 participants aged ≥20 years in the National Health and Nutrition Examination Survey (2003–2016) with information on blood concentrations of cadmium and lead, RDW and socio-demographic factors. In models adjusted for age, sex, race/ethnicity, education, poverty income ratio, BMI, alcohol consumption, smoking status and serum cotinine, RDW was increasingly elevated across progressively higher quartiles of blood cadmium concentration. A doubling of cadmium concentration was associated with 0.16 higher RDW (95% CI: 0.14, 0.18) and a doubling of lead concentration with 0.04 higher RDW (95% CI: 0.01, 0.06). Also, higher cadmium and lead concentrations were associated with increased odds of high RDW (RDW>14.8%). The associations were more pronounced in women and those with low-to-normal mean corpuscular volume (MCV) and held even after controlling for iron, folate or vitamin B12 deficiencies. In analysis including both metals, cadmium remained associated with RDW, whereas the corresponding association for lead was substantially attenuated. In this general population sample, blood cadmium and lead exposures were positively associated with RDW. The associations may indicate hemolytic or erythropoietic mechanisms by which exposure increases mortality risk.

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