scholarly journals Erratum to: Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

2017 ◽  
Vol 71 (4) ◽  
pp. 683-684
Author(s):  
Thanchanok Puksasook ◽  
Shinya Kimura ◽  
Sarin Tadtong ◽  
Jutamas Jiaranaikulwanitch ◽  
Jaturong Pratuangdejkul ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Evaluation ◽  
Targeted Agents ◽  
Resveratrol Derivatives

Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

2017 ◽  
Vol 71 (4) ◽  
pp. 665-682 ◽  
Author(s):  
Thanchanok Puksasook ◽  
Shinya Kimura ◽  
Sarin Tadtong ◽  
Jutamas Jiaranaikulwanitch ◽  
Jaturong Pratuangdejkul ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Evaluation ◽  
Targeted Agents ◽  
Resveratrol Derivatives

Novel multi-targeted agents for Alzheimer's disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles

2017 ◽  
Vol 72 ◽  
pp. 208-214 ◽  
Author(s):  
Keriman Ozadali-Sari ◽  
Tuba Tüylü Küçükkılınç ◽  
Beyza Ayazgok ◽  
Ayla Balkan ◽  
Oya Unsal-Tan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Modeling ◽  
Biological Evaluation ◽  
Targeted Agents

Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-β imaging in Alzheimer’s disease

2014 ◽  
Vol 22 (15) ◽  
pp. 4189-4197 ◽  
Author(s):  
Chun-Jen Chen ◽  
Kazunori Bando ◽  
Hiroki Ashino ◽  
Kazumi Taguchi ◽  
Hideaki Shiraishi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Biological Evaluation ◽  
Imidazopyridine Derivatives ◽  
Synthesis And Biological Evaluation

Silibinin-Albumin Nanoparticles: Characterization and Biological Evaluation Against Oxidative Stress-Stimulated Neurotoxicity Associated with Alzheimer’s Disease

2021 ◽  
Vol 17 (6) ◽  
pp. 1123-1130
Author(s):  
Qichen Pan ◽  
Yunchao Ban ◽  
Lijun Xu
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Cell Viability ◽  
Antioxidant Activities ◽  
Drug Loading ◽  
Biological Evaluation ◽  
Neural Cells ◽  
Nanoparticles Characterization

Alzheimer’s disease (AD) is strongly associated with oxidative stress which can damage neural cells. Silibinin has shown potential antioxidative effects. However, due to its low solubility in water, silibinin provides low biological activity and bioavailability. Therefore, to increase its pharmacological effects, silibilin was encapsulated into human serum albumin (HSA) nanoparticles and well-characterized by DLS and TEM techniques. The antioxidant activity of silibinin-HSA nanoparticles was evaluated on LPS-induced oxidative stress in neuron-like cells (SH-SY5Y) through MTT, antioxidant activity and apoptotic assay. It was shown that the mean diameter of HSA and silibinin-HSA nanoparticles were 88 and 105 nm, respectively with a drug loading of 24.08%, drug encapsulation rate of 94.72%, and the yield of silibinin-HSA nanoparticles of around 83.41% and the HSA nano-formulation released silibinin for 15 h. The results displayed that cell viability was reduced by LPS (10 μg/mL), who’s also determined to stimulate oxidative stress and apoptosis. However, co-incubation of cells with silibinin (50 μg/mL) or silibinin-HSA nanoparticles led to the recovery of cell viability, activation of SOD and CAT, increase of GSH content, and reduction of ROS level, Caspase-3 activity and fragmentation of DNA. It was also indicated that the neuroprotective and antioxidant activities of silibinin-HAS nanoparticles was greater than free silibinin, indicating that using albumin can be a potential formulation approach for improving the antioxidant efficacy of silibinin.

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