The expression and bioinformatic analysis of a novel gene C20orf14 associated with lymphoma

2008 ◽  
Vol 28 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Liangping Su ◽  
Deng Chen ◽  
Jianming Zhang ◽  
Ximing Li ◽  
Guihong Pan ◽  
...  
Keyword(s):  
Bioinformatic Analysis ◽  
Novel Gene

scholarly journals Identification and Characterization of a Novel Gene, hshB, in Xanthomonas oryzae pv. oryzicola Co-Regulated by Quorum Sensing and clp

2012 ◽  
Vol 102 (3) ◽  
pp. 252-259 ◽  
Author(s):  
Yancun Zhao ◽  
Guoliang Qian ◽  
Jiaqin Fan ◽  
Fangqun Yin ◽  
Yijin Zhou ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Extracellular Polysaccharide ◽  
Bioinformatic Analysis ◽  
Xanthomonas Oryzae ◽  
Pcr Analysis ◽  
Homologous Gene ◽  
Upstream Gene ◽  
Novel Gene ◽  
Putative Signal Peptide ◽  
Diffusible Signal Factor

Virulence factors of Xanthomonas oryzae pv. oryzicola, the causal agent of bacterial leaf streak in rice, are regulated by a diffusible signal factor (DSF)-dependent quorum-sensing (QS) system. In this study, a novel pathogenicity-related gene, Xoryp_010100018570 (named hshB), of X. oryzae pv. oryzicola was characterized. hshB encodes a hydrolase with a putative signal peptide, which is a homolog of imidazolonepropionase. Bioinformatic analysis showed that hshB is relatively conserved in the genus Xanthomonas but the homologous gene of hshB was not found in X. oryzae pv. oryzae. Reverse-transcription polymerase chain reaction (PCR) analysis showed that hshB and its upstream gene, Xoryp_010100018565 (named hshA), are co-transcribed in X. oryzae pv. oryzicola. Subsequent experimental results indicated that mutation of hshB remarkably impaired the virulence, extracellular protease activity, extracellular polysaccharide production, growth in minimal medium, and resistance to oxidative stress and bismerthiazol of X. oryzae pv. oryzicola. Mutation of clp, encoding a global regulator, resulted in similar phenotypes. Real-time PCR assays showed that hshB transcription is positively regulated by clp and DSF, and induced by poor nutrition. Our study not only found a novel gene hshB regulated by DSF-dependent QS system and clp but also showed that hshB was required for virulence of X. oryzae pv. oryzicola.

Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

2007 ◽  
Vol 1 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Xiangyang Bai ◽  
Duozhuang Tang ◽  
Tao Zhu ◽  
Lishi Sun ◽  
Lingling Yan ◽  
...  
Keyword(s):  
Bioinformatic Analysis ◽  
Novel Gene

EMBJ08, a novel gene promoting cell proliferation

2010 ◽  
Vol 34 (8) ◽  
pp. S50-S50
Author(s):  
Jing Li ◽  
Dongxia Hao ◽  
Weiwei Deng ◽  
Na Li ◽  
Shai Guo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Novel Gene

1650: Novel Gene Expression Markers in Renal Tumors Using Rt-PCR on Fixed Tissues Useful in Differentiating Histologic Subtypes

2004 ◽  
Vol 171 (4S) ◽  
pp. 436-436
Author(s):  
John A. Petros ◽  
Audry N. Schuetz ◽  
Andrew N. Young ◽  
Q. Yin Goen ◽  
So Dug Lim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Tumors ◽  
Rt Pcr ◽  
Novel Gene ◽  
Histologic Subtypes
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