Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio Cannot Predict Lymph Node Metastasis and Prognosis in Patients with Early Gastric Cancer: a Single Institution Investigation in China

2018 ◽  
Vol 38 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Guang-sheng Zhu ◽  
Shao-bo Tian ◽  
Hui Wang ◽  
Mao-guang Ma ◽  
Ya Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Single Institution ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Node Metastasis ◽  
Platelet Lymphocyte Ratio

Significance as a recurrence predictor of postoperative neutrophil-lymphocyte ratio in patients with stage II/III gastric cancer: A retrospective study.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 45-45
Author(s):  
Hiroaki Tanaka ◽  
Kazuya Muguruma ◽  
Katsunobu Sakurai ◽  
Takahiro Toyokawa ◽  
Naoshi Kubo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Lymph Node Metastasis ◽  
Peritoneal Dissemination ◽  
Stage Ii ◽  
Diffuse Type ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Node Metastasis

45 Background: Tumor markers such as carcinoembryonic antigen (CEA) and CA 19-9 are both widely used in the follow up of patients with gastric cancer. However, there are no definitive predictive markers for postopetrative recurrence. It has been reported that preoperative neutrophil lymphocyte ratio (NLR) was associated with prognosis of patients with gastrointestinal cancer. The aim of this study was to examine the impact of postoperative NLR on prediction for postoperative recurrence of gastric cancer. Methods: We retrospective reviewed data from 318 patients with Stage II/III gastric cancer who underwent curative surgical resection followed by adjuvant chemotherapy for between 2006 and 2013. Patients treated with preoperative chemotherapy or multiple cancers were excluded. Results: We found 118 recurrent diseases which mainly included 47 cases with peritoneal dissemination, 27 with distant lymph node metastasis and 24 with liver metastasis. Postoperative NLR was calculated every 6 months and the data at the time of recurrence or last survival were used for analysis. In univariate analysis, histological diffuse type, mascroscopical type 4 cancer, regional lymph node metastasis, lymphatic invasion in primary tumor, tumor diameter, elevated CEA or CA19-9, and elevated NLR were associated with poor prognosis. In multivariate analysis, we found that elevated CA19-9 and NLR were independent predictive markers. Increased NLR was associated with diffuse type, peritoneal dissemination, elevated CEA and preoperative NLR but not with adverse effect of adjuvant chemotherapy. Conclusions: The postoperative NLR might be one of the surrogate markers for recurrence after curative surgery for patients with Stage II/III gastric cancer.

Preoperative Neutrophil-Lymphocyte Ratio Before Platelet-Lymphocyte Ratio Predicts Clinical Outcome in Patients With Cervical Cancer Treated With Initial Radical Surgery

2014 ◽  
Vol 24 (7) ◽  
pp. 1319-1325 ◽  
Author(s):  
Yu Zhang ◽  
Le Wang ◽  
Yunduo Liu ◽  
Shuxiang Wang ◽  
Pan Shang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Confidence Interval ◽  
Radical Hysterectomy ◽  
Pelvic Lymphadenectomy ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Node Metastasis ◽  
Platelet Lymphocyte Ratio

ObjectiveSeveral inflammatory parameters are applied to predict the survival of patients with various cancers. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are 2 nonspecific markers of systemic inflammation. This study aimed to evaluate the clinicopathologic and prognostic values of NLR and PLR in patients with cervical cancer undergoing primary radical hysterectomy with pelvic lymphadenectomy.MethodsA total of 460 cervical cancer patients were enrolled in this study. These patients were histologically confirmed with cervical cancer from February 2005 to June 2008, at the Department of Gynecology, the Third Affiliated Hospital of Harbin Medical University, China. Their clinical and histopathological markers and complete blood counts were collected and analyzed. Prognostic factors were assessed by univariate and multivariate analyses.ResultsThe median NLR and PLR were 2.213 and 150.9, respectively. The clinicopathologic analysis showed that NLR was highly associated with depth of stromal infiltration (P = 0.007) and lymph node metastasis (P = 0.003), and PLR was significantly related to tumor size (P = 0.020) and lymph node metastasis (P = 0.027).Univariate analysis identified high NLR as a statistically significant poor predictive factor for the progression-free survival (PFS) (P = 0.008) and overall survival (OS) (P = 0.014), and PLR exhibited no significance on PFS (P = 0.075) and OS (P = 0.110).Multivariable analysis showed that the NLR was an independent prognostic marker for PFS (hazard ratio, 1.799; 95% confidence interval, 1.069–3.028; P = 0.027), but not for OS (hazard ratio, 1.631; 95% confidence interval, 0.968–2.750; P = 0.066).ConclusionsPreoperative NLR and PLR were found to be correlated to unfavorable histopathologic features of cervical cancer. The preoperative NLR, but not PLR, may be used as a potential and easy biomarker for survival prognosis in patients with cervical cancer receiving initial radical hysterectomy with pelvic lymphadenectomy.

scholarly journals A case of lymph node metastasis following a curative endoscopic submucosal dissection of an early gastric cancer

2011 ◽  
Vol 15 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Hisaharu Oya ◽  
Takuji Gotoda ◽  
Tetsu Kinjo ◽  
Haruhisa Suzuki ◽  
Shigetaka Yoshinaga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Node Metastasis ◽  
Submucosal Dissection

Relationship between preoperative clinicopathologic characteristics and lymph node metastasis in early gastric cancer

2007 ◽  
Vol 19 (2) ◽  
pp. 89-93
Author(s):  
Cai-Gang Liu ◽  
Ping Lu ◽  
Yang Lu ◽  
Rui-shan Zhang ◽  
Feng Jin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Clinicopathologic Characteristics ◽  
Node Metastasis

Mucin gene expression and lymph node metastasis in early gastric cancer

1998 ◽  
Vol 114 ◽  
pp. A623
Author(s):  
HR Kim ◽  
SJ Pang ◽  
HY Jung ◽  
WS Hong ◽  
YI Min ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Node Metastasis ◽  
Mucin Gene

Oncologic Safety of Endoscopic Resection Based on Lymph Node Metastasis in Ulcerative Early Gastric Cancer

2019 ◽  
Vol 29 (9) ◽  
pp. 1105-1110 ◽  
Author(s):  
Ji Won Kim ◽  
Hyuk Lee ◽  
Yang Won Min ◽  
Byung-Hoon Min ◽  
Jun Haeng Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Node Metastasis
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