Mo1171 The Incidence of Lymph Node Metastasis in Early Gastric Cancer According to the Expanded Criteria in Comparison to the Absolute Criteria. A Systemic Review and Meta-Analysis

2017 ◽  
Vol 85 (5) ◽  
pp. AB448 ◽  
Author(s):  
Mohamed M. Abdelfatah ◽  
Mohamed Barakat ◽  
Mohamed O. Othman
2020 ◽  
Vol 13 ◽  
pp. 175628482093503
Author(s):  
Bolun Jiang ◽  
Li Zhou ◽  
Jun Lu ◽  
Yizhi Wang ◽  
Junchao Guo

Background: It is challenging to identify the prevalence of lymph node metastasis (LNM) and residual tumor in patients with early gastric cancer (EGC) who underwent noncurative endoscopic resection (ER). This present meta-analysis was aimed to establish imperative potential predictive factors in order to select the optimal treatment method. Methods: A systematic literature search of PubMed, Embase, and Cochrane Library databases was performed through 1 February 2019 to identify relevant studies, which investigated risk factors for LNM and residual tumor in patients with EGC who underwent noncurative ER. Eligible data were systematically reviewed through a meta-analysis. Results: Overall, 12 studies investigating the risk factor of LNM were included, totaling 3015 patients, 7 of which also involved cancer residues. After the present meta-analysis, six predictors, including tumor size >30 mm, tumor invasion depth (⩾500 μm from the muscularis mucosae), macroscopic appearance, undifferentiated histopathological type, positive vertical margin, and presence of lymphovascular invasion (including lymphatic invasion and vascular invasion) were significantly associated with LNM, whereas tumor size >30 mm, positive horizontal margin, and positive vertical margin were identified as significant predictors for the risk of residual tumor. No evidence of publication bias was observed. Conclusions: Six and three variables were established as significant risk factors for LNM and residual tumor in patients with EGC who underwent noncurative ER, respectively. Patients with EGC who present these risk factors after noncurative ER are strongly suggested to receive additional surgery, while others might be suitable for strict follow-up. This might shed some new light on the selection of follow-up treatment for noncurative ER.


2020 ◽  
Vol 115 (1) ◽  
pp. S673-S674
Author(s):  
Daryl Ramai ◽  
Mohamed Barakat ◽  
Mohamed Othman ◽  
Peter Shajan ◽  
Ali M. Ahmed ◽  
...  

2017 ◽  
Vol 87 (12) ◽  
pp. 981-986 ◽  
Author(s):  
Xudong Zhao ◽  
Aizhen Cai ◽  
Hongqing Xi ◽  
Yanjing Song ◽  
Yi Wang ◽  
...  

2018 ◽  
Vol 33 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Mohamed M. Abdelfatah ◽  
Mohamed Barakat ◽  
Mohamed O. Othman ◽  
Ian S. Grimm ◽  
Noriya Uedo

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