The Role of the Transdiaphragmatic Pressure Gradient (TGP) in the Pathophysiology of Proximal Reflux

ABSTRACT Gastroesophageal reflux disease (GERD) is the most common disease of the upper gastrointestinal tract in the Western world. GERD pathophysiology is multifactorial. Different mechanisms may contribute to GERD including an increase in the transdiaphragmatic pressure gradient (TPG). The pathophysiology of GERD linked to TPG is not entirely understood. This review shows that TPG is an important contributor to GERD even when an intact esophagogastric barrier is present in the setting of obesity and pulmonary diseases.

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312 THE ROLE OF TRANSDIAPHRAGMATIC PRESSURE GRADIENT (TGP) IN THE PATHOPHYSIOLOGY OF HEIGHT REFLUX IN INDIVIDUALS WITH INCREASED TGP.

Gastroenterology ◽

10.1016/s0016-5085(20)34443-7 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-1510

Author(s):

Leonardo M. Del Grande ◽

Fernando A.M. Herbella ◽

Marco G. Patti

Keyword(s):

Pressure Gradient ◽

Transdiaphragmatic Pressure

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Transdiaphragmatic Pressure Gradient (TPG) Has a Central Role in the Pathophysiology of Gastroesophageal Reflux Disease (GERD) in the Obese and it Correlates with Abdominal Circumference but Not with Body Mass Index (BMI)

Obesity Surgery ◽

10.1007/s11695-019-04345-x ◽

2019 ◽

Vol 30 (4) ◽

pp. 1424-1428 ◽

Cited By ~ 3

Author(s):

Leonardo de Mello Del Grande ◽

Fernando Augusto Mardiros Herbella ◽

Rafael Caue Katayama ◽

William Guidini Lima ◽

Marco G Patti

Keyword(s):

Body Mass Index ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Pressure Gradient ◽

Body Mass ◽

Reflux Disease ◽

Abdominal Circumference ◽

Transdiaphragmatic Pressure

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TCT-565: The Role of Pull-Back Pressure Gradient in Percutaneous Transluminal Angioplasty for Central Vein stenosis in Dialysis Patients

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2011.10.579 ◽

2011 ◽

Vol 58 (20) ◽

pp. B152-B153

Keyword(s):

Pressure Gradient ◽

Percutaneous Transluminal Angioplasty ◽

Transluminal Angioplasty ◽

Back Pressure ◽

Central Vein ◽

Dialysis Patients ◽

Vein Stenosis ◽

Percutaneous Transluminal ◽

Central Vein Stenosis

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Finite element analysis of an elastic model of the brain: Distortion due to acute epidural hematoma–the role of the intra-ventricular pressure gradient

Computer Aided Surgery ◽

10.3109/10929080701294828 ◽

2007 ◽

Vol 12 (2) ◽

pp. 131-136

Author(s):

Hooshang Saberi ◽

Amir Saied Seddighi ◽

Farhad Farmanzad

Keyword(s):

Finite Element Analysis ◽

Finite Element ◽

Pressure Gradient ◽

Epidural Hematoma ◽

Ventricular Pressure ◽

Elastic Model ◽

Element Analysis ◽

Acute Epidural Hematoma ◽

The Brain

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BLOOD FLOW THROUGH A CIRCULAR PIPE WITH AN IMPULSIVE PRESSURE GRADIENT

Mathematical Models and Methods in Applied Sciences ◽

10.1142/s0218202500000124 ◽

2000 ◽

Vol 10 (02) ◽

pp. 187-202 ◽

Cited By ~ 25

Author(s):

GIUSEPPE PONTRELLI

Keyword(s):

Blood Flow ◽

Finite Difference ◽

Finite Difference Method ◽

Unsteady Flow ◽

Pressure Gradient ◽

Collocation Method ◽

Difference Method ◽

Flow Through ◽

Impulsive Pressure

The unsteady flow of a viscoelastic fluid in a straight, long, rigid pipe, driven by a suddenly imposed pressure gradient is studied. The used model is the Oldroyd-B fluid modified with the use of a nonconstant viscosity, which includes the effect of the shear-thinning of many fluids. The main application considered is in blood flow. Two coupled nonlinear equations are solved by a spectral collocation method in space and the implicit trapezoidal finite difference method in time. The presented results show the role of the non-Newtonian terms in unsteady phenomena.

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Enhanced settling of nonheavy inertial particles in homogeneous isotropic turbulence: The role of the pressure gradient and the Basset history force

Physical Review E ◽

10.1103/physreve.95.023106 ◽

2017 ◽

Vol 95 (2) ◽

Cited By ~ 8

Author(s):

M. A. T. van Hinsberg ◽

H. J. H. Clercx ◽

F. Toschi

Keyword(s):

Pressure Gradient ◽

Isotropic Turbulence ◽

Inertial Particles ◽

Homogeneous Isotropic Turbulence ◽

History Force

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Prognostic role of the initial portal pressure gradient reduction after TIPS in patients with cirrhosis

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0b013e3282eeb488 ◽

2007 ◽

Vol 19 (10) ◽

pp. 846-852 ◽

Cited By ~ 9

Author(s):

Erwin Biecker ◽

Felix Roth ◽

Jörg Heller ◽

Hans H. Schild ◽

Tilman Sauerbruch ◽

...

Keyword(s):

Pressure Gradient ◽

Portal Pressure ◽

Prognostic Role

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On the Role of Correlation Between Instantaneous Velocity and Pressure-Gradient in Large-Scale Turbulence

Volume 2: Symposia, Parts A, B, and C ◽

10.1115/fedsm2003-45355 ◽

2003 ◽

Author(s):

Shinnosuke Obi

Keyword(s):

Pressure Gradient ◽

Reynolds Stress ◽

Large Scale ◽

Stress Component ◽

Turbulent Transport ◽

Velocity Correlation ◽

Gradient Diffusion ◽

Scale Turbulence ◽

The Individual

Turbulent transport of Reynolds stress by triple moment of fluctuating velocity and pressure-velocity correlation are evaluated from a DNS for wake of a rectangular cylinder located in a uniform flow. The turbulent diffusion transport of turbulent kinetic energy hardly correlates with its gradient vector, indicating that the generally accepted gradient diffusion model is inadequate. It is inferred that the separate modeling of the individual Reynolds stress component provides a better possibility for modeling the turbulent transport in this flow, because of the strong departure from the equilibrium state of turbulence. The possibility of the direct modeling of the pressure gradient-velocity correlation is discussed.

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