Effects of Chai-Qin-Cheng-Qi decoction (柴芩承气汤) on acute pancreatitis-associated lung injury in mice with acute necrotizing pancreatitis

2012 ◽  
Author(s):  
Lei Huang ◽  
Ming-hao Wang ◽  
Zheng-yu Cheng ◽  
Ping Xue ◽  
Tao Jin ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Necrotizing Pancreatitis ◽  
Acute Necrotizing Pancreatitis ◽  
Acute Necrotizing

scholarly journals Polyethylene Glycol 35 (PEG35) Protects against Inflammation in Experimental Acute Necrotizing Pancreatitis and Associated Lung Injury

2020 ◽  
Vol 21 (3) ◽  
pp. 917 ◽  
Author(s):  
Ana Ferrero-Andrés ◽  
Arnau Panisello-Roselló ◽  
Anna Serafín ◽  
Joan Roselló-Catafau ◽  
Emma Folch-Puy
Keyword(s):  
Acute Pancreatitis ◽  
Cell Death ◽  
Lung Injury ◽  
Lung Tissue ◽  
Necrotizing Pancreatitis ◽  
Sodium Taurocholate ◽  
Water Soluble ◽  
Acute Necrotizing Pancreatitis ◽  
Inflammatory Disorder ◽  
Acute Necrotizing

Acute pancreatitis is an inflammatory disorder of the pancreas. Its presentation ranges from self-limiting disease to acute necrotizing pancreatitis (ANP) with multiorgan failure and a high mortality. Polyethylene glycols (PEGs) are non-immunogenic, non-toxic, and water-soluble chemicals composed of repeating units of ethylene glycol. The present article explores the effect of PEG35 administration on reducing the severity of ANP and associated lung injury. ANP was induced by injection of 5% sodium taurocholate into the biliopancreatic duct. PEG35 was administered intravenously either prophylactically or therapeutically. Three hours after ANP induction, pancreas and lung tissue samples and blood were collected and ANP severity was assessed. To evaluate the inflammatory response, gene expression of pro-inflammatory cytokines and chemokine and the changes in the presence of myeloperoxidase and adhesion molecule levels were determined in both the pancreas and the lung. To evaluate cell death, lactate dehydrogenase (LDH) activity and apoptotic cleaved caspase-3 localization were determined in plasma and in both the pancreatic and lung tissue respectively. ANP-associated local and systemic inflammatory processes were reduced when PEG35 was administered prophylactically. PEG35 pre-treatment also protected against acute pancreatitis-associated cell death. Notably, the therapeutic administration of PEG35 significantly decreased associated lung injury, even when the pancreatic lesion was equivalent to that in the untreated ANP-induced group. Our results support a protective role of PEG35 against the ANP-associated inflammatory process and identify PEG35 as a promising tool for the treatment of the potentially lethal complications of the disease.

Effects of Berberine on Acute Necrotizing Pancreatitis and Associated Lung Injury

Pancreas ◽  
2017 ◽  
Vol 46 (8) ◽  
pp. 1046-1055 ◽  
Author(s):  
Sun-Bok Choi ◽  
Gi-Sang Bae ◽  
Il-Joo Jo ◽  
Ho-Joon Song ◽  
Sung-Joo Park
Keyword(s):  
Lung Injury ◽  
Necrotizing Pancreatitis ◽  
Acute Necrotizing Pancreatitis ◽  
Acute Necrotizing

scholarly journals Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis

2007 ◽  
Vol 13 (46) ◽  
pp. 6172 ◽  
Author(s):  
Oge Tascilar ◽  
Güldeniz Karadeniz Cakmak ◽  
Ishak Ozel Tekin ◽  
Ali Ugur Emre ◽  
Bulent Hamdi Ucan ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rat Model ◽  
Necrotizing Pancreatitis ◽  
Acute Necrotizing Pancreatitis ◽  
Protective Effects ◽  
Acute Necrotizing

The burden of acute pancreatitis and early experience of step-up approach for acute necrotizing pancreatitis at Military Hospital

2019 ◽  
Vol 22 (2) ◽  
pp. 11-17
Author(s):  
Sushil Bahadur Rawal ◽  
Uttam Laudari ◽  
Basanta Khatiwada ◽  
Anup Thapa ◽  
Manoj Kumar Jha ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Necrotizing Pancreatitis ◽  
Early Experience ◽  
Acute Necrotizing Pancreatitis ◽  
Military Hospital ◽  
Army Hospital ◽  
Acute Necrotizing ◽  
Hospital Resources ◽  
Open Necrosectomy

Introduction: Twenty-five percent of acute pancreatitis develops severe acute pancreatitis (SAP). SAP patients have prolonged hospitalization and require a substantial amount of manpower and hospital resources. The aim of this study was to give an insight into the burden of acute pancreatitis at a tertiary level military hospital and to share the experience of managing pancreatic necrosis with the application of the step-up approach. Methods: A prospective descriptive study of consecutive patients was conducted at Shree Birendra Army Hospital from 2017 June to 2017 November. Patients with a diagnosis of acute pancreatitis admitted were stratified according to severity as per Revised Atlanta classification 2012. Patients with acute necrotizing pancreatitis were enrolled for the step-up approach. Patient’s demography, baseline investigations, radiology, prognostic scoring scales and type of intervention were analyzed. The burden of severe acute pancreatitis at our center and the early experience of the step-up approach at our centre within the study period were studied. Results: Out of 35 five patients with acute pancreatitis, 7 (20%) subsequently developed severe acute pancreatitis. Among them, five patients subsequently developed necrotizing pancreatitis who were managed according to the step-up approach. Out of them, three patients subsequently underwent operative intervention in the form of minimally invasive procedures like percutaneous drain placement, laparoscopic necrosectomy, video-assisted retroperitoneal debridement, and open necrosectomy. Conclusion: Acute pancreatitis is a common presentation at our centre. The step-up approach in the management of acute necrotizing pancreatitis is a safe and feasible approach.

Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

2010 ◽  
Vol 160 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Melike Karen ◽  
Osman Yuksel ◽  
Nalan Akyürek ◽  
Ebru Ofluoğlu ◽  
Kayhan Çağlar ◽  
...  
Keyword(s):  
Lung Injury ◽  
Necrotizing Pancreatitis ◽  
Saccharomyces Boulardii ◽  
Acute Necrotizing Pancreatitis ◽  
Acute Necrotizing

Frequency of Left Plueral Effusion in Acute Necrotizing Pancreatitis

2021 ◽  
Vol 15 (10) ◽  
pp. 3349-3351
Author(s):  
Hunain . ◽  
Farah Saleem ◽  
Muhammad Waqas Arshad ◽  
Kauser Shaikh ◽  
Mamoona Shaikh ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Pleural Effusion ◽  
Serum Amylase ◽  
Necrotizing Pancreatitis ◽  
Case Series ◽  
Acute Necrotizing Pancreatitis ◽  
Amylase Level ◽  
X Ray ◽  
Left Pleural Effusion ◽  
Acute Necrotizing

Objective: The aim of this study is to calculate the prevalence of left plueral effusion in acute necrotizing pancreatitis. Study Design: Observational/ case series Place and Duration: Conducted at surgery department of Saidu Teaching Hospital, Swat and Ibne Sina Hospital and Research Institute, Multan for duration of six months from January 2021 to June 2021. Methods: A total of 95 patients, both males and females, ranging in age from 15 to 65 years, were presented. After receiving informed written consent, the baseline comprehensive demographics of the patients presented were recorded, including age, gender, and body mass index. Patients with acute pancreatitis and serum amylase levels greater than 300U/dL were eligible to participate. Patients were subjected to X-ray and CT scans in their entirety. Prevalence of necrotizing pancreatitis was calculated by CT scan and for left plueral effusion X-ray of chest was taken. SPSS 24.0 version was used to analyze complete data. Results: Majority of the patients 65 (68.4%) were females and 30 (31.6%) were males with mean age 39.14+5.67 years. 26 (27.4%) cases had BMI less than 20kg/m2 and the majority were >20kg/m2. Gallstone was the most common cause of acute pancreatitis found in 45 (47.4%) cases, followed by alcoholism 25 (26.3%) and medications 12 (12.6%). Among 95 cases, prevalence of necrotizing pancreatitis was 42 (44.2%) in which 40 cases had left plueral effusion. Mortality rate among necrotizing pancreatitis was 13 (33.3%). Conclusion: We found that the majority of individuals with necrotizing pancreatitis experienced pleural effusion on the left side. Thus, patients with acute pancreatitis who have a high serum amylase level must be treated earlier if they have a left pleural effusion because of severity. Keywords: Plueral Effusion, Acute Necrotizing Pancreatitis, Mortality

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