Cardiovascular autonomic nervous system function and hip fracture risk: the Cardiovascular Health Study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Phyllis K. Stein ◽  
Petra Buzkova ◽  
Howard A. Fink ◽  
John A. Robbins ◽  
Kenneth J. Mukamal ◽  
...  
2021 ◽  
Vol 13 (5) ◽  
pp. 2439
Author(s):  
Alexis Espinoza-Salinas ◽  
Edgardo Molina-Sotomayor ◽  
Johnattan Cano-Montoya ◽  
Jose Antonio Gonzalez-Jurado

Autonomic nervous system function is an important predictor of physical fitness. The objective of this study was to find out the associations of autonomic activity parameters, lipid profile, insulin concentrations, and insulin resistance in overweight men with the level of physical activity. A descriptive and correlational study was carried out in 28 overweight men: 14 physically active (PA) and 14 physically inactive (PI). The following variables were assessed: Level of physical activity, HRV (heart rate variability), basal insulin, HOMA-IR index (Homeostasis Model Assessment Insulin-Resistance), and lipid profile. The main results show a positive correlation between the spectral parameters of the HRV and total cholesterol (r = 0.24), LDL (r = 0.59), VLDL (r = 0.86), and insulin (r = 0.88) of sedentary people, evidencing a directly proportional correlation with BMI. We conclude that weight gain and a sedentary lifestyle are associated with an increase in sympathetic discharge, which, in turn, is associated with an increase in lipid profile and insulin levels.


1990 ◽  
Vol 5 (3) ◽  
pp. 251-254 ◽  
Author(s):  
Reetta Kälviäinen ◽  
Tapani Keränen ◽  
Juha Mustonen ◽  
Esko Länsimies ◽  
Paavo Johannes Riekkinen

Author(s):  
Zoe M. Jenkins ◽  
David J. Castle ◽  
Nina Eikelis ◽  
Andrea Phillipou ◽  
Gavin W. Lambert ◽  
...  

2009 ◽  
Vol 15 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Shu-Chuan Lin ◽  
Min-Lih Huang ◽  
Shwu-Jiuan Liu ◽  
Ya-Fen Huang ◽  
Shang-Chi Chiang ◽  
...  

2014 ◽  
Vol 05 (19) ◽  
pp. 1189-1199
Author(s):  
Kaixin Tian ◽  
Jun Qin ◽  
Lan Huang ◽  
Min Long ◽  
Shiyong Yu ◽  
...  

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Willem J Kop ◽  
Phyllis K Stein ◽  
Joshua I Barzilay ◽  
Russell P Tracy ◽  
John S Gottdiener

The increased cardiovascular (CV) risk associated with depression is hypothesized to be explained by autonomic nervous system (ANS) dysregulation and inflammatory processes. This study determines the role of ANS dysregulation and inflammation in the predictive value of depression for CV mortality. 908 participants of the Cardiovascular Health Study (age 71±5 yrs) free of CV disease were evaluated for depression (CES-D scale), ANS dysregulation by abnormal non-linear heart rate variability (decreased short-term fractal scaling exponent), and inflammation (IL-6, CRP, fibrinogen and WBC). Predictors of CV mortality were examined using Cox regression analysis, adjusting for age, sex, race, systolic blood pressure, diabetes, subclinical disease, use of beta-blockers, smoking status, BMI, and physical activity (median follow-up=13.3 yrs). Risks were calculated for subgroups based on the presence or absence of depression, and ANS or inflammatory CV risk factors (Figure ). Depression was predictive of CV mortality (RR=1.88, CI=1.23–2.86), ANS dysregulation (p=0.014) and inflammatory markers (IL-6 p=0.072; WBC p=0.033; and fibrinogen p=0.050) were correlated with depression. The association of depression with CV mortality occurred primarily in the presence of ANS dysregulation and/or inflammation (Figure ). Addition of ANS and inflammatory markers to the multivariate model did not substantially reduce the CV mortality risk of depression (adjusted RR=1.65, CI=1.03–2.65). Depression is predictive of cardiovascular mortality, and the elevated risk is additive to autonomic nervous system dysregulation and inflammation


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