Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia

2020 ◽  
Author(s):  
Qi Qin ◽  
Yi Tang ◽  
Xuejiao Dou ◽  
Yida Qu ◽  
Yi Xing ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Deficits ◽  
Default Mode Network ◽  
Vascular Cognitive Impairment ◽  
Default Mode ◽  
Subcortical Vascular Cognitive Impairment ◽  
Cognitive Impairment No Dementia

scholarly journals AEROBIC TRAINING, THE DEFAULT MODE NETWORK, AND COGNITION IN OLDER ADULTS WITH MILD VASCULAR COGNITIVE IMPAIRMENT

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S55-S55
Author(s):  
Rachel A Crockett ◽  
Chun Liang Hsu ◽  
Cindy Barha ◽  
Ging-Yuek Robin Hsiung ◽  
Teresa Liu-Ambrose
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Aerobic Training ◽  
Vascular Cognitive Impairment ◽  
Default Mode ◽  
Global Cognitive Function

Abstract Aerobic training has been shown to be effective at improving cognitive and brain outcomes in older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI). However, uncertainty remains regarding the underlying neurobiological mechanisms by which exercise elicits these improvements in cognition. Increased aberrant functional connectivity of the default mode network has been highlighted as a factor contributing to cognitive decline in older adults with cognitive impairment. Greater connectivity of the DMN at rest is associated with poorer performance on attention-demanding tasks, indicative of a lack of ability to deactivate the network on task. Our previous work on a randomized controlled trial of participants with mild SIVCI, demonstrated that 6-months of thrice weekly aerobic training led to improved global cognitive function, as measured by Alzheimer’s disease Assessment Scale-Cognitive subscale (ADAS-Cog), compared with a health education program. Thus, we conducted secondary analyses to investigate whether these changes in global cognitive function were associated with changes in resting state DMN connectivity. A subsample of 21 participants underwent a resting state functional magnetic resonance imaging (fMRI) scan before and after trial completion. Change in resting state DMN connectivity was found to significantly predict change in ADAS-Cog score (β = -.442, p=.038) after controlling for age, intervention group, and baseline functional capacity (R2=.467, F(4,16)= 3.507, p=.031). These findings suggest that functional connectivity of the DMN may underlie changes in global cognitive function. Furthermore, aerobic exercise is a promising intervention by which to elicit these changes in older adults with mild SIVCI.

[P1-368]: LACK OF SELF-AWARENESS OF COGNITIVE DEFICITS PREDICTS DEFAULT MODE NETWORK METABOLIC DECLINE IN MILD COGNITIVE IMPAIRMENT

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P401-P401
Author(s):  
Joseph Therriault ◽  
Kok Pin Ng ◽  
Tharick A. Pascoal ◽  
Min Su Kang ◽  
Sulantha S. Mathotaarachchi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Deficits ◽  
Default Mode Network ◽  
Self Awareness ◽  
Default Mode

scholarly journals Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review

2015 ◽  
Vol 9 (4) ◽  
pp. 394-404 ◽  
Author(s):  
Felipe Kenji Sudo ◽  
Gilberto Sousa Alves ◽  
Chan Tiel ◽  
Letice Ericeira-Valente ◽  
Denise Madeira Moreira ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Deficits ◽  
Neuropsychological Tests ◽  
Vascular Cognitive Impairment ◽  
Operational Criteria ◽  
Key Terms ◽  
The Impact ◽  
Normal Controls ◽  
Cognitive Impairment No Dementia

ABSTRACT The recognition of Cerebrovascular Disease (CVD) at earlier clinical stages may favor the control of vascular risk factors and prevention of dementia. However, operational criteria for symptomatic phases at non-dementia stages are often difficult, as the current criteria normally require the evidence of extensive subcortical disease. OBJECTIVE To identify the neuroimaging profile of Vascular Mild Cognitive Impairment (VaMCI), the impact of those aspects over cognition and the neuropsychological tests that distinguished VaMCI from other groups. METHODS Searches were performed in Scopus, ISI and PsycINFO, using the following key terms: "vascular mild cognitive impairment" OR "vascular cognitive impairment no dementia" OR "vascular cognitive impairment not demented" OR "subcortical mild cognitive impairment". RESULTS Of 249 papers, 20 studies were selected. Ten of those included only patients with severe White Matter Hyperintensities (WMH), whereas 10 others admitted subjects with moderate-to-severe WMH. Both groups showed poor performances in Executive Function (EF) tasks in comparison to normal controls and other diagnostic groups. Among EF tests, those assessing "complex" EF abilities consistently distinguished VaMCI from other groups, regardless of the severity of WMH. VaMCI subjects with severe or moderate-to-severe WMH showed cognitive deficits in comparison with other groups. "Complex" EF tests were the most useful in differentiating those patients from the other groups. CONCLUSION The occurrence of VaMCI may be associated with the presence of CVD at moderate levels; the detection of vascular damage at earlier stages may allow the adoption of therapeutic actions with significant effect-sizes.

Subcortical Vascular Cognitive Impairment, No Dementia

2014 ◽  
Vol 31 (5) ◽  
pp. 422-428 ◽  
Author(s):  
Rishi V. A. Sheorajpanday ◽  
Peter Mariën ◽  
Guy Nagels ◽  
Arie J. T. M. Weeren ◽  
Jos Saerens ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Vascular Cognitive Impairment ◽  
Subcortical Vascular Cognitive Impairment ◽  
Cognitive Impairment No Dementia

Differences in structural and functional default mode network connectivity in amyloid positive mild cognitive impairment: a longitudinal study

2021 ◽  
Author(s):  
Thamires Naela Cardoso Magalhães ◽  
Christian Luiz Baptista Gerbelli ◽  
Luciana Ramalho Pimentel-Silva ◽  
Brunno Machado de Campos ◽  
Thiago Junqueira Ribeiro de Rezende ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Study ◽  
Default Mode Network ◽  
Network Connectivity ◽  
Default Mode
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