scholarly journals White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation

2021 ◽  
Author(s):  
Akram Zamani ◽  
Terence J. O’Brien ◽  
Jeff Kershaw ◽  
Leigh A. Johnston ◽  
Bridgette D. Semple ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Diffusion Weighted Imaging ◽  
Pediatric Traumatic Brain Injury ◽  
White Matter Changes ◽  
Diffusion Weighted

Diffusion-Weighted Imaging Improves Outcome Prediction in Pediatric Traumatic Brain Injury

2008 ◽  
Vol 25 (10) ◽  
pp. 1153-1162 ◽  
Author(s):  
Nicholas R. Galloway ◽  
Karen A. Tong ◽  
Stephen Ashwal ◽  
Udochukwu Oyoyo ◽  
André Obenaus
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Diffusion Weighted Imaging ◽  
Outcome Prediction ◽  
Pediatric Traumatic Brain Injury ◽  
Diffusion Weighted

scholarly journals P.122 Restricted diffusion of white matter in infants with subdural hematoma

2016 ◽  
Vol 43 (S2) ◽  
pp. S48-S48
Author(s):  
CA Elliott ◽  
V Mehta ◽  
V Ramaswamy
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Diffusion Weighted Imaging ◽  
White Matter Injury ◽  
Restricted Diffusion ◽  
Cortical Atrophy ◽  
Diffusion Restriction ◽  
Subdural Hematomas ◽  
Diffusion Weighted

Background: Inflicted head injury is a major cause of infant morbidity and mortality. The extent of traumatic brain injury in infants is often best characterized by diffusion weighted magnetic resonance imaging. In this cases series we describe four infants aged 6-19 months, with small unilateral subdural hematomas secondary to abusive head trauma accompanied by extensive areas of restricted diffusion weighted imaging isolated to the cerebral white matter. Methods: Retrospective, single-centre case series of four children with small unilateral subdural hematomas with early and delayed MR imaging with diffusion weighted imaging. Results: In three cases there was acute diffusion restriction ispilateral to the subdural, while in one case diffusion restriction was present bilaterally. All patients had multiple seizures and bilateral multilayered retinal hemorrhages. After non-surgical treatment, all patients survived albeit with significant motor and cognitive deficits and significant cortical atrophy on long-term followup imaging. Conclusions: These four cases highlight that relatively small subdural hematomas following child abuse can manifest with extensive white matter injury only evident at early stages with diffusion weighted imaging. We propose that selective white matter injury as a result of either reperfusion or axonal degeneration in response to the initial insult accounts for this novel pattern of infantile traumatic brain injury.

scholarly journals Frontostriatal White Matter Integrity Relations with “Cool” and “Hot” Self-Regulation after Pediatric Traumatic Brain Injury

2021 ◽  
Vol 38 (1) ◽  
pp. 122-132
Author(s):  
Jesse T. Fischer ◽  
Paul T. Cirino ◽  
Dana DeMaster ◽  
Candice Alfano ◽  
Johanna Bick ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Self Regulation ◽  
White Matter Integrity ◽  
Pediatric Traumatic Brain Injury

White Matter Changes Caused by Mild Traumatic Brain Injury in Mice Evaluated Using Neurite Orientation Dispersion and Density Imaging

2020 ◽  
Vol 37 (16) ◽  
pp. 1818-1828
Author(s):  
Lisa M. Gazdzinski ◽  
Miranda Mellerup ◽  
Tong Wang ◽  
Seyed Amir Ali Adel ◽  
Jason P. Lerch ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
White Matter Changes

scholarly journals Long-Term White Matter Changes after Severe Traumatic Brain Injury: A 5-Year Prospective Cohort

2013 ◽  
Vol 35 (1) ◽  
pp. 23-29 ◽  
Author(s):  
J. Dinkel ◽  
A. Drier ◽  
O. Khalilzadeh ◽  
V. Perlbarg ◽  
V. Czernecki ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Severe Traumatic Brain Injury ◽  
Prospective Cohort ◽  
White Matter Changes

scholarly journals Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?

2022 ◽  
Vol 11 (2) ◽  
pp. 358
Author(s):  
Francesco Latini ◽  
Markus Fahlström ◽  
Fredrik Vedung ◽  
Staffan Stensson ◽  
Elna-Marie Larsson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Diffusion Tensor ◽  
Global Analysis ◽  
Memory Performance ◽  
Regional Analysis ◽  
Long Term Memory ◽  
Post Injury ◽  
White Matter Changes

Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of post-injury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (p < 0.01). At the regional white matter analysis, the left frontal aslant tract, anterior thalamic radiation, and the genu of the corpus callosum displayed focal changes in both groups compared with HC but with different trends. Both TBI and rSRC displayed worse memory performance compared with HC (p < 0.05). While global analysis of DTI-based parameters did not reveal common abnormalities in TBI and rSRC, abnormalities to the fronto-thalamic network were observed in both groups using regional analysis of the white matter pathways. These results may be valuable to tailor individualized rehabilitative approaches for post-injury cognitive impairment in both TBI and rSRC patients.

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