Temporal dynamics alterations of spontaneous neuronal activity in anterior cingulate cortex predict suicidal risk in bipolar II patients

2021 ◽  
Author(s):  
Shui Tian ◽  
Rongxin Zhu ◽  
Mohammad Ridwan Chattun ◽  
Huan Wang ◽  
Zhilu Chen ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Temporal Dynamics ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Suicidal Risk ◽  
Bipolar Ii ◽  
Spontaneous Neuronal Activity

Human Anterior Cingulate Cortex Neurons Modulated by Attention-Demanding Tasks

2000 ◽  
Vol 83 (6) ◽  
pp. 3575-3577 ◽  
Author(s):  
Karen D. Davis ◽  
William D. Hutchison ◽  
Andres M. Lozano ◽  
Ronald R. Tasker ◽  
Jonathan O. Dostrovsky
Keyword(s):  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Cognitive Functions ◽  
Single Neuron ◽  
Direct Evidence ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Cognitive State ◽  
Imaging Studies ◽  
Spontaneous Neuronal Activity

Recent imaging studies have implicated the anterior cingulate cortex (ACC) in various cognitive functions, including attention. However, until now, there was no evidence for changes in neuronal activity of individual ACC neurons during performance of tasks that require attention and effortful thought. We hypothesized these neurons must exist in the human ACC. In this study, we present electrophysiological data from microelectrode single neuron recordings in the human ACC of neuronal modulation during attention-demanding tasks in 19% of 36 neurons tested. These findings provide the first direct evidence of an influence of a cognitive state on the spontaneous neuronal activity of human ACC neurons.

Neuronal activity of the anterior cingulate cortex during an observation-based decision making task in monkeys

2012 ◽  
Vol 230 (1) ◽  
pp. 48-61 ◽  
Author(s):  
Mariana F.P. de Araujo ◽  
Etsuro Hori ◽  
Rafael S. Maior ◽  
Carlos Tomaz ◽  
Taketoshi Ono ◽  
...  
Keyword(s):  
Decision Making ◽  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Cingulate Cortex ◽  
Anterior Cingulate

Activity Profiles of Single Neurons in Caudal Anterior Cingulate Cortex During Trace Eyeblink Conditioning in the Rabbit

2003 ◽  
Vol 90 (2) ◽  
pp. 599-612 ◽  
Author(s):  
Aldis P. Weible ◽  
Craig Weiss ◽  
John F. Disterhoft
Keyword(s):  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Eyeblink Conditioning ◽  
Neuronal Response ◽  
Trace Conditioning ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Excitatory Response ◽  
Excitatory Responses ◽  
Trace Eyeblink Conditioning

Acquisition of trace eyeblink conditioning involves the association of a conditioned stimulus (CS) with an unconditioned stimulus (US) separated by a stimulus-free trace interval. This form of conditioning is dependent upon the hippocampus and the caudal anterior cingulate cortex (AC), in addition to brain stem and cerebellar circuitry. Hippocampal involvement in trace eyeblink conditioning has been studied extensively, but the involvement of caudal AC is less well understood. In the present study, we compared neuronal responses from rabbits given either paired (trace conditioning) or unpaired (pseudoconditioning) presentations of the CS and US. Presentation of the CS elicited significant increases in neuronal activity at the onset of both trace conditioning and pseudoconditioning. A robust CS-elicited neuronal response persisted throughout the first 2 days of trace conditioning, declining gradually across subsequent training sessions. In contrast, the magnitude of the CS-elicited excitatory response during pseudoconditioning began to decline within the first 10 trials. Neurons exhibiting excitatory responses to the CS during trace conditioning also exhibited excitatory responses to the US that were significantly greater in magnitude than US-elicited responses during pseudoconditioning. CS-elicited decreases in neuronal activity became more robust over the course of trace conditioning compared to pseudoconditioning. Reductions in activity during the CS interval consistently preceded excitation in both training groups, suggesting that the CS-elicited decreases in neuronal activity may serve to increase the signal-to-noise ratio of the excitatory response to the tone. Taken together, these data suggest that the caudal AC is involved early in trace eyeblink conditioning and that maintenance of the CS-elicited excitatory response may serve to signal the salience of the tone.

scholarly journals Neuronal Activity in Dorsal Anterior Cingulate Cortex during Economic Choices under Variable Action Costs

2021 ◽  
Author(s):  
Xinying Cai ◽  
Camillo Padoa-Schioppa
Keyword(s):  
Decision Making ◽  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Reference Frames ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Decision Variables ◽  
The One ◽  
Economic Choices

The role of the dorsal anterior cingulate cortex (ACCd) in decision making has often been discussed but remains somewhat unclear. On the one hand, numerous studies implicated this area in decisions driven by effort or action cost. On the other hand, work on economic choices between goods (under fixed action costs) found that neurons in ACCd encoded only post-decision variables. To advance our understanding of the role played by this area in decision making, we trained monkeys to choose between different goods (juice types) offered in variable amounts and with different action costs. Importantly, the task design dissociated computation of the action cost from planning of any particular action. Neurons in ACCd encoded the chosen value and the binary choice outcome in several reference frames (chosen juice, chosen cost, chosen action). Thus, this area provided a rich representation of post-decision variables. In contrast, neurons in ACCd did not represent pre-decision variables such as individual offer values in any reference frame. Hence, ongoing decisions are unlikely guided by ACCd. Conversely, neuronal activity in this area might inform subsequent choices.

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