Structural characterization and bioactive and functional properties of the Brown macroalgae (Sargassum illicifolium) polysaccharide

Author(s):  
Parisa Abbas Zadeh Ghanavati ◽  
Mojgan Khodadadi ◽  
Mehrnoosh Tadayoni

2018 ◽  
Vol 95 (8) ◽  
pp. 991-1000 ◽  
Author(s):  
Mallory E. Walters ◽  
Chibuike C. Udenigwe ◽  
Apollinaire Tsopmo


2020 ◽  
Vol 160 ◽  
pp. 758-768 ◽  
Author(s):  
Reihaneh Sorourian ◽  
Amir Eghbal Khajehrahimi ◽  
Mehrnoosh Tadayoni ◽  
Mohammad Hossein Azizi ◽  
Mohammad Hojjati


2008 ◽  
Vol 94 (2) ◽  
pp. 277-287 ◽  
Author(s):  
Arun K. Mishra ◽  
Christina Klein ◽  
Sudagar S. Gurcha ◽  
Luke J. Alderwick ◽  
Ponnusamy Babu ◽  
...  


2002 ◽  
Vol 277 (51) ◽  
pp. 49247-49255 ◽  
Author(s):  
Camilla Westling ◽  
Ulf Lindahl

Functional properties of heparan sulfate (HS) are generally ascribed to the sulfation pattern of the polysaccharide. However, recently reported functional implications of rareN-unsubstituted glucosamine (GlcNH2) residues in native HS prompted our structural characterization of sequences around such residues. HS preparations were cleaved with nitrous acid at eitherN-sulfated orN-unsubstituted glucosamine units followed by reduction with NaB3H4. The labeled products were characterized following complementary deamination steps. The proportion of GlcNH2units varied from 0.7–4% of total glucosamine in different HS preparations. The GlcNH2units occurred largely clustered at the polysaccharide-protein linkage region in intestinal HS, also more peripherally in aortic HS. They were preferentially located withinN-acetylated domains, or in transition sequences betweenN-acetylated andN-sulfated domains, only 20–30% of the adjacent upstream and downstream disaccharide units beingN-sulfated. The nearest downstream (toward the polysaccharide-protein linkage) hexuronic acid was invariably GlcUA, whereas the upstream neighbor could be either GlcUA or IdoUA. The highly sulfated butN-unsubstituted disaccharide unit, -IdoUA2S-GlcNH26S-, was detected in human renal and porcine intestinal HS, but not in HS from human aorta. These results are interpreted in terms of a biosynthetic mechanism, whereby GlcNH2residues are formed through regulated, incomplete action of anN-deacetylase/N-sulfotransferase enzyme.



2018 ◽  
Vol 120 ◽  
pp. 1461-1467 ◽  
Author(s):  
Xianliang Luo ◽  
Qi Wang ◽  
Dongya Fang ◽  
Weijing Zhuang ◽  
Canhui Chen ◽  
...  


Author(s):  
Li‐kun Ren ◽  
Qing‐qi Guo ◽  
Yang Yang ◽  
Xiao‐fei Liu ◽  
Hua‐nan Guan ◽  
...  


2020 ◽  
Vol 164 ◽  
pp. 95-104
Author(s):  
Ichrak Joulak ◽  
Samia Azabou ◽  
Ilaria Finore ◽  
Annarita Poli ◽  
Barbara Nicolaus ◽  
...  


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