chitosan derivative
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RSC Advances ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 1095-1104
Author(s):  
Mahmoud H. Abu Elella ◽  
Ahmed Esmail Shalan ◽  
Magdy W. Sabaa ◽  
Riham R. Mohamed

This study aimed to show the efficacy of the one-pot green biosynthesis of nanocomposites as effective antimicrobial agents based on a water-soluble biodegradable polysaccharide and silver nitrate (AgNO3).


2021 ◽  
Vol 37 (6) ◽  
pp. 533-542
Author(s):  
Florencia Anabel Mesas ◽  
María Cecilia Terrile ◽  
María Ximena Silveyra ◽  
Adriana Zuñiga ◽  
María Susana Rodriguez ◽  
...  

Chitosan has been considered an environmental-friendly polymer. However, its use in agriculture has not been extended yet due to its relatively low solubility in water. N-Methylene phosphonic chitosan (NMPC) is a water-soluble derivative prepared by adding a phosphonic group to chitosan. This study demonstrates that NMPC has a fungicidal effect on the phytopathogenic fungus Fusarium solani f. sp. eumartii (F. eumartii) judged by the inhibition of F. eumartti mycelial growth and spore germination. NMPC affected fungal membrane permeability, reactive oxygen species production, and cell death. Also, this chitosan-derivative exerted antifungal effects against two other phytopathogens, Botrytis cinerea, and Phytophthora infestans. NMPC did not affect tomato cell viability at the same doses applied to these phytopathogens to exert fungicide action. In addition to water solubility, the selective biological cytotoxicity of NMPC adds value in its application as an antimicrobial agent in agriculture.


2021 ◽  
Vol 191 ◽  
pp. 19-26
Author(s):  
Andressa B. Nornberg ◽  
Thalita F.B. de Aquino ◽  
Carolina C. Martins ◽  
Cristiane Luchese ◽  
Ethel A. Wilhelm ◽  
...  

2021 ◽  
pp. 118762
Author(s):  
Liuqi Shi ◽  
Zhanrong Li ◽  
Zhen Liang ◽  
Junjie Zhang ◽  
Ruixing Liu ◽  
...  

2021 ◽  
Vol 7 (5) ◽  
pp. 4244-4253
Author(s):  
Jiangshan Wu ◽  
Jian Liu ◽  
Xingwei Huang ◽  
Zhenping Wei ◽  
Yifei Zeng

Sericin nanomicelles (Sericin-PBLG) have the properties of efficiently and stably encapsulating hydrophobic chemotherapeutics in aqueous solution. The vitamin B12 (VB12) modified amphiphilic chitosan derivative can improve the delivery effect of oral drugs and has a targeting function. In this study, a new type of sericin nanomedicine (VB12-sericin-PBLG-PTX) loaded with paclitaxel was successfully synthesized. The particle size of VB12-sericin-PBLG-PTX nanomicelles is 121.5 ±1.6 nm. The nanomicelles can reduce the activity of gastric carcinoma cells and gastric carcinoma drug-resistant cells, and increase the apoptosis rate of gastric carcinoma cells and gastric carcinoma drug-resistant cells, and achieve a good anti-tumor effect.


2021 ◽  
Vol 7 (10) ◽  
pp. 812
Author(s):  
Weslley Souza de Paiva ◽  
Moacir Fernandes Queiroz ◽  
Diego Araujo Sabry ◽  
André Luiz Cabral Monteiro de Azevedo Santiago ◽  
Guilherme Lanzi Sassaki ◽  
...  

Oxidative stress is the cause of numerous diseases in humans; therefore, there has been a continuous search for novel antioxidant molecules. Fungal chitosan is an attractive molecule that has several applications (antifungal, antibacterial, anticancer and antiparasitic action) owing to its unique characteristics; however, it exhibits low antioxidant activity. The aim of this study was to obtain fungal chitosan (Chit-F) from the fungus Rhizopus arrhizus and synthesize its derivative, fungal chitosan-gallic acid (Chit-FGal), as a novel antioxidant chitosan derivative for biomedical use. A low molecular weight Chi-F (~3.0 kDa) with a degree of deacetylation of 86% was obtained from this fungus. Chit-FGal (3.0 kDa) was synthesized by an efficient free radical-mediated method using hydrogen peroxide (H2O2) and ascorbic acid. Both Chit-F and Chit-FGal showed similar copper chelating activities; however, Chit-FGal was more efficient as an antioxidant, exhibiting twice the total antioxidant capacity than Chi-F (p < 0.05). Furthermore, H2O2 (0.06 M) promoted a 50% decrease in the viabilities of the 3T3 fibroblast cells. However, this effect was abolished in the presence of Chit-FGal (0.05–0.25 mg/mL), indicating that Chit-FGal protected the cells from oxidative damage. These results suggest that Chit-FGal may be a promising agent to combat oxidative stress.


Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 536
Author(s):  
Chaojie Xu ◽  
Ronge Xing ◽  
Song Liu ◽  
Yukun Qin ◽  
Kecheng Li ◽  
...  

Drug carrier nanoparticles (NPs) were prepared by the polyelectrolyte method, with chitosan sulfate, with different substituents and quaternary ammonium chitosan, including C236-HACC NPs, C36-HACC NPs, and C6-HACC NPs. To evaluate whether the NPs are suitable for loading different antigens, we chose bovine serum albumin (BSA), ovalbumin (OVA), and myoglobin (Mb) as model antigens to investigate the encapsulation effect of the NPs. The characteristics (size, potential, and encapsulation efficiency) of the NPs were measured. Moreover, the NPs with higher encapsulation efficiency were selected for the immunological activity research. The results showed that chitosan derivative NPs with different substitution sites had different loading effects on the three antigens, and the encapsulation rate of BSA and OVA was significantly better than that of Mb. Moreover, the NPs encapsulated with different antigens have different immune stimulating abilities to DCS cells, the immune effect of OVA-coated NPs was significantly better than that of BSA-coated NPs and blank NPs, especially C236-HACC-OVA NPs. Furthermore, we found that C236-HACC-OVA NPs could increase the phosphorylation level of intracellular proteins to activate cell pathways. Therefore, C236-HACC NPs are more suitable for the loading of antigens similar to the OVA structure.


2021 ◽  
Vol 36 (5) ◽  
pp. 414-430
Author(s):  
Xuqin Li ◽  
Zhou Lei ◽  
Jie Sheng ◽  
Yishan Song

In this study, a novel peptide grafted chitosan (CACS-FBP) with high peptide content, excellent moisture-absorption and moisture-retention abilities was prepared. Caffeic acid (CA) was used to modify chitosan, the highly water-soluble intermediate further reacted with fish bone collagen peptide to obtain the final product, and the synthesis of CACS-FBP was confirmed by the Fourier transform infrared spectroscopy (FT-IR), NMR, and UV-vis. The single-factor experiments indicated that the degree of substitution (DS) of CACS-FBP depended on the reaction temperature, reaction time, the mass ratio of fish bone collagen peptide to CACS (mFBP/mCACS) and the mass ratio of MTGase to CACS (mMTGase/mCACS). In addition, the antioxidant assay indicated that CACS-FBP had an excellent antioxidant capacity, and the CACS-FBP showed no cytotoxicity toward L929 mouse fibroblasts, all the results mean that the prepared peptide-containing chitosan derivative has potential application in pharmaceutical and biomedical fields.


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