scholarly journals Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients

2021 ◽  
Author(s):  
Elisabeta Malinici ◽  
Anca Sirbu ◽  
Miruna Popa ◽  
Marian Andrei ◽  
Sorin Ioacara ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Sleeve Gastrectomy ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Bone Mineral ◽  
Bone Health ◽  
Significant Loss ◽  
Baseline Body Mass Index ◽  
Mineral Density ◽  
Total Bone Mineral Density ◽  
The Impact

Abstract Purpose Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences in terms of evolution. Materials and Methods We conducted a retrospective study on 241 patients who underwent LSG to determine the regional and total BMD changes at 6 and 12 months after the intervention. Results One hundred ten males and 140 females (97 pre-, 43 postmenopausal) were included. Mean baseline body mass index (BMI) was 44.16 ± 6.11 kg/m2 in males and 41.60 ± 5.54 kg/m2 in females, reaching 28.62 ± 4.26 kg/m2 and 27.39 ± 4.2 kg/m2, respectively, at 12 months. BMD showed a continuous decline, with significant loss from 6 months postoperatively. There was a positive correlation between BMD and BMI decline at 12 months (r = 0.134, p < 0.05). Total BMD loss at 12 months was significantly greater in males than premenopausal females, independent of BMI variation and age. During the first 6 months, men lost significantly more bone mass than premenopausal and postmenopausal women (BMD variation was 2.62%, 0.27%, 1.58%, respectively). The second period (6–12 months) was similar in all three groups, revealing a further steady (~ 1.4%) BMD decline. Conclusions Our results are consistent with previous findings that LSG negatively impacts BMD, stressing the importance of bone health-oriented measures in postoperative care. Moreover, the impact that seems more significant in males warrants future exploration, as it might change clinical practice. Graphical abstract

scholarly journals Bone mineral density and body composition after laparoscopic sleeve gastrectomy in men: A short-term longitudinal study

2015 ◽  
Vol 23 ◽  
pp. 101-107 ◽  
Author(s):  
Piotr Adamczyk ◽  
Marek Bužga ◽  
Pavol Holéczy ◽  
Zdeněk Švagera ◽  
Vít Šmajstrla ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Sleeve Gastrectomy ◽  
Longitudinal Study ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Bone Mineral ◽  
Mineral Density ◽  
Short Term

scholarly journals The Connection Between Vitamin K and Bone Health

2015 ◽  
Vol 8 (2) ◽  
Author(s):  
Jamy (Ning) Fu
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vitamin K ◽  
Bone Health ◽  
Bone Fractures ◽  
The Body ◽  
Mineral Density ◽  
Densité Minérale Osseuse ◽  
The Impact ◽  
Viable Method

Vitamin K is essential to the body because it is known to help blood coagulate and activate osteocalcin, a protein involved in maintaining healthy bones. In this review, one study observing the impact of vitamin K supplementation on patients’ bone mineral densities and three studies focusing on the effects of vitamin K supplementation on the incidence of bone fractures are discussed to determine whether the vitamin may be important for maintaining bone health. While some promising results, such as an increase in bone mineral density of subjects after vitamin K supplementation arose, the conclusions reached by the four studies were not statistically significant enough to justify the importance of vitamin K in maintaining bone health. Well-controlled studies that are unbiased, statistically powerful, and focused on vitamin K’s effects on bone density are required in the future to provide further insight on whether vitamin K supplementation is a viable method of improving bone health. La vitamine K est essentielle pour le corps, car il est connu pour assister dans la coagulation du sang ainsi qu’activer l'ostéocalcine, une protéine impliquée dans le maintien de la santé des os. Ici, une étude dirigé vers les observations de l'impact de la consommation de suppléments de la vitamine K sur la densité minérale osseuse de patients, puis trois autres études portant sur les effets de la consommation de suppléments de la vitamine K sur l'incidence des fractures osseuses sont examinées afin de déterminer si la vitamine soit une facteur important dans le maintien de la santé des os. Tandis que des résultats sont révélés prometteurs, comme ceux montrant une augmentation de la densité minérale osseuse des sujets après la consommation des suppléments de la vitamine K, l’ensemble de conclusions tirées des quatre études ne présente pas suffisamment de données qui pourraient suggérer une corrélation entre la consommation des suppléments de la vitamine K et la santé des os. Des études supplémentaires portant sur les effets de la vitamine K sur la densité osseuse, mené dans des conditions contrôlés, bien conçus, impartiales, qui produiront des résultats persuasifs, sont nécessaires à être effectuer à l'avenir afin de donner un meilleur aperçu de l’effet de la supplémentation en vitamine K comme une méthode viable dans l’entretien de la santé des os.

scholarly journals A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations

2021 ◽  
Author(s):  
Marko Ugrica ◽  
Carla Bettoni ◽  
Soline Bourgeois ◽  
Arezoo Daryadel ◽  
Eva-Maria Pastor-Arroyo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Resorption ◽  
Bone Mineral ◽  
Bone Health ◽  
Ammonium Excretion ◽  
Mineral Density ◽  
Mature Adult ◽  
Phosphate Intake ◽  
The Impact ◽  
High Phosphate

Abstract Background Phosphate intake has increased in the last decades due to a higher consumption of processed foods. This higher intake is detrimental for patients with chronic kidney disease, increasing mortality and cardiovascular disease risk and accelerating kidney dysfunction. Whether a chronic high phosphate diet is also detrimental for the healthy population is still under debate. Methods We fed healthy mature adult mice over a period of one year with either a high (1.2% w/w) or a standard (0.6% w/w) phosphate diet, and investigated the impact of a high phosphate diet on mineral homeostasis, kidney function and bone health. Results The high phosphate diet increased plasma phosphate, parathyroid hormone (PTH) and calcitriol levels, with no change in fibroblast growth factor 23 levels. Urinary phosphate, calcium and ammonium excretion were increased. Measured glomerular filtration rate was apparently unaffected, while blood urea was lower and urea clearance was higher in animals fed the high phosphate diet. No change was observed in plasma creatinine levels. Blood and urinary pH were more acidic paralleled by higher bone resorption observed in animals fed a high phosphate diet. Total and cortical bone mineral density was lower in animals fed a high phosphate diet and this effect is independent of the higher PTH levels observed. Conclusions A chronic high phosphate intake did not cause major renal alterations, but affected negatively bone health, increasing bone resorption and decreasing bone mineral density.

scholarly journals Impact of hypogonadism on bone mineral density and vertebral fractures in HIV-infected men

2021 ◽  
Author(s):  
L. C. Pezzaioli ◽  
T. Porcelli ◽  
A. Delbarba ◽  
F. Maffezzoni ◽  
E. Focà ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Bone Health ◽  
Sex Hormone Binding Globulin ◽  
Gonadal Function ◽  
Mineral Density ◽  
T Score ◽  
Normal Bone Mineral Density ◽  
The Impact

Abstract Purpose Hypogonadism and osteoporosis are frequently reported in HIV-infected men and, besides multifactorial pathogenesis, they might be directly linked because of testicular involvement in bone health. We evaluated the prevalence of osteoporosis and vertebral fractures (VFs) in HIV-infected men, and assessed their relationship with gonadal function. Methods We enrolled 168 HIV-infected men (median age 53). Osteoporosis and osteopenia were defined with T-score ≤  – 2.5SD and T-score between  – 1 and  – 2.5SD, respectively. VFs were assessed by quantitative morphometric analysis. Total testosterone (TT), calculated free testosterone (cFT), Sex Hormone Binding Globulin (SHBG), Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) were obtained; overt hypogonadism was defined on symptoms and low TT or cFT, and classified into primary and secondary according to gonadotropins; compensated hypogonadism was defined as normal TT and cFT with high LH levels. Results Overall, osteoporosis and osteopenia were found in 87.5% of patients, and VFs were detected in 25% of them; hypogonadism was identified in 26.2% of cases. Osteoporotic patients had higher SHBG vs those with normal bone mineral density (BMD). Fractured patients were more frequently hypogonadal and with higher SHBG. SHBG showed negative correlation with both spine and femoral BMD, and positive correlation with VFs. In multivariate models, FSH showed negative impact only on femoral BMD, whereas older age and higher SHBG predicted VFs. Conclusion We found a high burden of bone disease and hypogonadism in HIV-infected men, and we showed that the impact of gonadal function on bone health is more evident on VFs than on BMD.

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