Dissolution of Soap Scum by Surfactant. Part II: Effects of NaCl and Added Chelant on Equilibrium Solubility and Dissolution Rate of Calcium Soap Scum in Amphoteric Surfactant Solutions

2014 ◽  
Vol 17 (5) ◽  
pp. 859-864 ◽  
Author(s):  
Sawwalak Itsadanont ◽  
Darunrat Ratanalert ◽  
Sukhwan Soontravanich ◽  
John F. Scamehorn ◽  
David A. Sabatini ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Amphoteric Surfactant ◽  
Calcium Soap ◽  
Equilibrium Solubility ◽  
Surfactant Solutions ◽  
Soap Scum

scholarly journals The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Xiaoyu Sui ◽  
Yan Chu ◽  
Jie Zhang ◽  
Honglian Zhang ◽  
Huiyu Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dissolution Rate ◽  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Dissolution Behavior ◽  
Enhancement Effect ◽  
Glycyrrhetic Acid ◽  
Equilibrium Solubility ◽  
Drug Molecules ◽  
Pvp K30

The effect of polyvinylpyrrolidone (PVP) as glycyrrhetic acid (GA) solid dispersions carrier at different molecular weights on the dissolution behavior and physicochemical properties was investigated. PVP-GA-SDs prepared with all four molecular weight PVPs displayed good enhancement of dissolution rate and equilibrium solubility compared with pure drug and corresponding physical mixtures. The results showed that the enhancement effect of molecular weight on dissolution rate and equilibrium solubility follows PVP   K 30 > PVP   K 60 > PVP   K 17 > PVP   K 15 . In addition, the dissolution rate and solubility of the SDs with a carrier-drug ratio of 8 : 1 were better than the samples of 4 : 1. The DSC and XRD patterns showed that the crystallization of GA in SDs prepared by PVP K30 and PVP K60 was significantly inhibited, and both were transformed to amorphous. Based on FTIR and Raman detection, a hydrogen-bond between PVP and drug molecules is formed. SEM results showed that there were no significant differences in the appearance of SDs prepared with four PVPs, and no crystalline morphology of GA was seen. In conclusion, the findings of this study demonstrated that the dissolution performance of the PVP-GA-SDs prepared by the solvent method is related to the molecular weight of PVP, and the change in the molecular weight of PVP does not cause a monotonic change in dissolution of GA. The samples with PVP K30 as the carrier have the best dissolution performance.

Dissolution Study of Salt of Long Chain Fatty Acids (Soap Scum) in Surfactant Solutions. Part II: Kinetics of Dissolution

2010 ◽  
Vol 13 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Sukhwan Soontravanich ◽  
J. Grant Landrum ◽  
Sarah A. Shobe ◽  
Chase M. Waite ◽  
John F. Scamehorn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Long Chain Fatty Acids ◽  
Dissolution Study ◽  
Surfactant Solutions ◽  
Soap Scum ◽  
Kinetics Of Dissolution ◽  
Kinetics Of ◽  
Long Chain ◽  
Chain Fatty Acids

Dissolution Study of Salt of Long Chain Fatty Acids (Soap Scum) in Surfactant Solutions. Part I: Equilibrium Dissolution

2010 ◽  
Vol 13 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Sukhwan Soontravanich ◽  
Heyde E. Lopez ◽  
John F. Scamehorn ◽  
David A. Sabatini ◽  
David R. Scheuing
Keyword(s):  
Fatty Acids ◽  
Long Chain Fatty Acids ◽  
Dissolution Study ◽  
Surfactant Solutions ◽  
Soap Scum ◽  
Long Chain ◽  
Chain Fatty Acids

Equilibrium solubility measurement of compounds with low dissolution rate by Higuchi's Facilitated Dissolution Method. A validation study

2017 ◽  
Vol 106 ◽  
pp. 133-141 ◽  
Author(s):  
Krisztina Takács-Novák ◽  
Maria Urac ◽  
Péter Horváth ◽  
Gergely Völgyi ◽  
Bradley D. Anderson ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Validation Study ◽  
Equilibrium Solubility ◽  
Dissolution Method ◽  
Solubility Measurement

Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique

2016 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Neelima Rani T ◽  
Pavani A ◽  
Sobhita Rani P ◽  
Srilakshmi N
Keyword(s):  
Dissolution Rate ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Onset Of Action ◽  
Kneading Method ◽  
Wetting Property ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Low Solubility

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

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